DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lds and Hel89B

DIOPT Version :9

Sequence 1:	NP_524850.2	Gene:	lds / 45894	FlyBaseID:	FBgn0002542	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001287351.1	Gene:	Hel89B / 41943	FlyBaseID:	FBgn0022787	Length:	1923	Species:	Drosophila melanogaster

Alignment Length:	1009	Identity:	239/1009 - (23%)
Similarity:	408/1009 - (40%)	Gaps:	290/1009 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 PRYTTQFAGNIQNDLHSTIGAADSEVLDDSSGSDVLILSNKETPIEILSSTDDDATTNKENMSGP 230
            |.:|.:....::. |..|  ...|||:::.....:|.|:.::|.          .|||..:.:|.
  Fly  1009 PEFTPKLVMPLET-LKQT--PVSSEVINNCVYYGILTLALQQTV----------TTTNTRSGAGG 1060

  Fly   231 PFERPSKSLSPRSSAGASVVKTSKNLSQPTIQAVLK---QKTSPAAPRRSRIKSEDQKVVSQVVY 292
            . ..|:.:.:||   |.....|.:.||.....|.::   |:...|..::.||    |::.:....
  Fly  1061 A-TTPTATTAPR---GPGRPPTGEILSATNATAHIELKAQQAKEAEAKQCRI----QRLGAACAI 1117

  Fly   293 DEEMRKLAEKRVQVSDAEKLFEKVA---HKLPDKGSQIMK-----RIDTLRRELAMDEQWISALR 349
            ::..|..         .|::.||||   |.:..|..|.:|     |:.:|..:|.:..:.:|:::
  Fly  1118 EKLCRIF---------GEQIIEKVAVFQHLMFGKVEQFVKEAYDWRLGSLLPDLGVCNELVSSMQ 1173

  Fly   350 VQQSNVPAVRV--------VKPTL-----NPPRA------------PSID---TLDW-------- 378
            :.::..|.:.|        :.|:|     :|.:|            ..||   |:.:
  Fly  1174 LIETAAPHLHVALHPQMFALLPSLGFIVCHPLKAVRHMAARCIAVLAEIDACQTMQFVVHDLLPL 1238

  Fly   379 ----DELSE---AVNEIKPVYTGAQ---------------GMATFNNQ--KALTLESLKDLHVSL 419
                ::|.|   |:..|:.|.:..|               |..:..::  :.|:.....:| |.|
  Fly  1239 LGKIEQLIERQGAIEAIERVVSRLQIKVVPYIVLLVVPLLGAMSDPDESVRLLSTHCFANL-VQL 1302

  Fly   420 EDLPG-PEVLAED---------------------------PVGLKVSLMNHQKHALAWMSWRERK 456
            ..|.| .|.|..|                           ||.:.|.|..:|:..:.|: |...|
  Fly  1303 MPLDGKTEQLKSDPLQARKTRDREFLDYLFNPKSIPNYKVPVPISVELRCYQQAGINWL-WFLNK 1366

  Fly   457 LPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKD 521
            ....|||.|||||||||..| .:||                   .|..:::..::....|
  Fly  1367 YNLHGILCDDMGLGKTLQTI-CILA-------------------GDHMHRQTANLANLPS----- 1406

  Fly   522 TRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKYLRDY----DIVVTTYQIV 582
                  ||:||.:|...|..|||..:.:..:...:|:......:.|...|.    ::||.:|..|
  Fly  1407 ------LVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDIGTKCNLVVASYDTV 1465

  Fly   583 AREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLK 647
               .|.:....|:.:...:|||.|:::|.|::||.|:..|:..:|..|:||||||..|::::|..
  Fly  1466 ---RKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFD 1527

  Fly   648 FLRCSPFDDLHTWKKWI-----------DNKSAGGQNRLNLL-MKSL-------MLRRTKAQLQS 693
            ||...   .|.|.|:::           |.||:..:....:| |::|       :|||.|..:
  Fly  1528 FLMPG---FLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDV-- 1587

  Fly   694 DGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQ 758
               |..||.|..:.:...|...::.:|:                      ||:.:.  .|...::
  Fly  1588 ---LKDLPPKITQDLLCELSPLQLRLYE----------------------DFSNKH--LKDCLDK 1625

  Fly   759 IKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSSD 823
            :.|.:.         |.|.......|:| |...|..|:.:|.||.|:  :...||
  Fly  1626 LGDSSS---------ASMVTENLSAKTH-IFQALRYLQNVCNHPKLV--LRQSEE---------- 1668

  Fly   824 SDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRP 888
                   |....::||::::|.|..:..|.        ||       |.|.||
  Fly  1669 -------LTKVTSQLALSNSSLDDIEHSAK--------LP-------ALKQLL------------ 1699

  Fly   889 SSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDI-----LRDHLSKDGVATLSLNGTIPVKNRQ 948
               ::..|.:...|:   |..:|::..|..::|||     ||.||  ..|..|.|:|::|...||
  Fly  1700 ---LDCGIGVQTESV---SQHRALIFCQLKAMLDIVEQDLLRRHL--PSVTYLRLDGSVPASQRQ 1756

  Fly   949 DIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVII 1013
            ||||.||. :....||||:...||:||||.||:.::.::..|||..:.||.||.:|:||||.|.:
  Fly  1757 DIVNNFNS-DPSIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNV 1820

  Fly  1014 YKFMCVDTVEQRIKGLQDKKLDLADGVLTGAKVS 1047
            |:.:..:::|::|.|||..|:..|:.|::....|
  Fly  1821 YRLITRNSLEEKIMGLQKFKILTANTVVSAENAS 1854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	SNF2_N	442..805	CDD:278600	94/385 (24%)
		DEXDc	459..634	CDD:238005	48/178 (27%)
		HELICc	885..1014	CDD:238034	50/133 (38%)
Hel89B	NP_001287351.1	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:288874	33/158 (21%)
		HEAT repeat	1234..1261	CDD:293787	5/26 (19%)
		HEAT repeat	1269..1298	CDD:293787	2/28 (7%)
		SNF2_N	1353..1662	CDD:278600	94/385 (24%)
		DEXDc	1370..1514	CDD:238005	48/177 (27%)
		Helicase_C	1689..1813	CDD:278689	52/159 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467224
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840