Protein Alignment lds and Hel89B

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Alignment Length: 1009
• Identity: 239/1009 - (23%)
• Similarity: 408/1009 - (40%)
• Gaps: 290/1009 - (28%)

  Fly   166 PRYTTQFAGNIQNDLHSTIGAADSEVLDDSSGSDVLILSNKETPIEILSSTDDDATTNKENMSGP 230
            |.:|.:....::. |..|  ...|||:::.....:|.|:.::|.          .|||..:.:|.
  Fly  1009 PEFTPKLVMPLET-LKQT--PVSSEVINNCVYYGILTLALQQTV----------TTTNTRSGAGG 1060

  Fly   231 PFERPSKSLSPRSSAGASVVKTSKNLSQPTIQAVLK---QKTSPAAPRRSRIKSEDQKVVSQVVY 292
            . ..|:.:.:||   |.....|.:.||.....|.::   |:...|..::.||    |::.:....
  Fly  1061 A-TTPTATTAPR---GPGRPPTGEILSATNATAHIELKAQQAKEAEAKQCRI----QRLGAACAI 1117

  Fly   293 DEEMRKLAEKRVQVSDAEKLFEKVA---HKLPDKGSQIMK-----RIDTLRRELAMDEQWISALR 349
            ::..|..         .|::.||||   |.:..|..|.:|     |:.:|..:|.:..:.:|:::
  Fly  1118 EKLCRIF---------GEQIIEKVAVFQHLMFGKVEQFVKEAYDWRLGSLLPDLGVCNELVSSMQ 1173

  Fly   350 VQQSNVPAVRV--------VKPTL-----NPPRA------------PSID---TLDW-------- 378
            :.::..|.:.|        :.|:|     :|.:|            ..||   |:.:
  Fly  1174 LIETAAPHLHVALHPQMFALLPSLGFIVCHPLKAVRHMAARCIAVLAEIDACQTMQFVVHDLLPL 1238

  Fly   379 ----DELSE---AVNEIKPVYTGAQ---------------GMATFNNQ--KALTLESLKDLHVSL 419
                ::|.|   |:..|:.|.:..|               |..:..::  :.|:.....:| |.|
  Fly  1239 LGKIEQLIERQGAIEAIERVVSRLQIKVVPYIVLLVVPLLGAMSDPDESVRLLSTHCFANL-VQL 1302

  Fly   420 EDLPG-PEVLAED---------------------------PVGLKVSLMNHQKHALAWMSWRERK 456
            ..|.| .|.|..|                           ||.:.|.|..:|:..:.|: |...|
  Fly  1303 MPLDGKTEQLKSDPLQARKTRDREFLDYLFNPKSIPNYKVPVPISVELRCYQQAGINWL-WFLNK 1366

  Fly   457 LPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKD 521
            ....|||.|||||||||..| .:||                   .|..:::..::....|
  Fly  1367 YNLHGILCDDMGLGKTLQTI-CILA-------------------GDHMHRQTANLANLPS----- 1406

  Fly   522 TRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKYLRDY----DIVVTTYQIV 582
                  ||:||.:|...|..|||..:.:..:...:|:......:.|...|.    ::||.:|..|
  Fly  1407 ------LVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDIGTKCNLVVASYDTV 1465

  Fly   583 AREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLK 647
               .|.:....|:.:...:|||.|:::|.|::||.|:..|:..:|..|:||||||..|::::|..
  Fly  1466 ---RKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFD 1527

  Fly   648 FLRCSPFDDLHTWKKWI-----------DNKSAGGQNRLNLL-MKSL-------MLRRTKAQLQS 693
            ||...   .|.|.|:::           |.||:..:....:| |::|       :|||.|..:
  Fly  1528 FLMPG---FLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDV-- 1587

  Fly   694 DGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQ 758
               |..||.|..:.:...|...::.:|:                      ||:.:.  .|...::
  Fly  1588 ---LKDLPPKITQDLLCELSPLQLRLYE----------------------DFSNKH--LKDCLDK 1625

  Fly   759 IKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSSD 823
            :.|.:.         |.|.......|:| |...|..|:.:|.||.|:  :...||
  Fly  1626 LGDSSS---------ASMVTENLSAKTH-IFQALRYLQNVCNHPKLV--LRQSEE---------- 1668

  Fly   824 SDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRP 888
                   |....::||::::|.|..:..|.        ||       |.|.||
  Fly  1669 -------LTKVTSQLALSNSSLDDIEHSAK--------LP-------ALKQLL------------ 1699

  Fly   889 SSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDI-----LRDHLSKDGVATLSLNGTIPVKNRQ 948
               ::..|.:...|:   |..:|::..|..::|||     ||.||  ..|..|.|:|::|...||
  Fly  1700 ---LDCGIGVQTESV---SQHRALIFCQLKAMLDIVEQDLLRRHL--PSVTYLRLDGSVPASQRQ 1756

  Fly   949 DIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVII 1013
            ||||.||. :....||||:...||:||||.||:.::.::..|||..:.||.||.:|:||||.|.:
  Fly  1757 DIVNNFNS-DPSIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNV 1820

  Fly  1014 YKFMCVDTVEQRIKGLQDKKLDLADGVLTGAKVS 1047
            |:.:..:::|::|.|||..|:..|:.|::....|
  Fly  1821 YRLITRNSLEEKIMGLQKFKILTANTVVSAENAS 1854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	210/877 (24%)
		DEXHc_TTF2	439..686	CDD:350830	72/269 (27%)
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447	33/158 (21%)
		HepA	<1342..1849	CDD:440319	172/638 (27%)