DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lds and CG10445

DIOPT Version :9

Sequence 1:	NP_524850.2	Gene:	lds / 45894	FlyBaseID:	FBgn0002542	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster

Alignment Length:	992	Identity:	351/992 - (35%)
Similarity:	503/992 - (50%)	Gaps:	169/992 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 LDDSSGSDVLILSNKETPIEILSSTDDDATTNKENMSGPPFERPSKSLSPRSSAGASVVKTSKNL 256
            ::.||.||...:..:...|:..||.....::.:.|....|....|..||...:...|.:..|
  Fly     1 MESSSPSDTTEIHKQSCSIQDQSSVPVPDSSGEINNWMEPEPVDSLELSGEYADNESAIFVS--- 62

  Fly   257 SQPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRVQVSDAEKLFEKVAHKLP 321
                        .|....::::|....||:::......::.:.|.:..::.|.:...||:..:|.
  Fly    63 ------------ASEYNEKKAQIDQLVQKILTMEQQQRQLEENASETKELCDLKLHLEKLNARLE 115

  Fly   322 DKGSQIMKRIDTLRRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPSIDTLDWDELSEAVN 386
            ..|    :.:||||  |..|:|   .::::.::    .:|..|..|         .|..|...:|
  Fly   116 ALG----EFLDTLR--LREDQQ---EIKIEDNS----ELVDHTEQP---------KWSNLYSGLN 158

  Fly   387 EI--KPVYTGAQGMATFNNQKALTLESLKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAW 449
            ..  |..:|.||    |...|:..::|||.|:..::..|..:.|.:.|..|.|.|:.||:..|.|
  Fly   159 RYRQKANHTAAQ----FYQHKSNIIDSLKTLYEPIQPRPAIDDLEKQPALLLVRLLKHQQSCLKW 219

  Fly   450 MSWRERKLPRGGILADDMGLGKTLTMISSVLA----------------------------CKNGQ 486
            |.:|||:...||||||||||||||:||:.:||                            ||..:
  Fly   220 MQFRERQKISGGILADDMGLGKTLSMIALILASEETKNRKREEKKKALTLKWTQEFNRVYCKEIR 284

  Fly   487 EMSEGKDESSDSDSE--------------------------DDKNKKRKSVTGWKSK-------- 517
            ::|...||......|                          ||.:...|:|...:.|
  Fly   285 KISMFDDEEESGKEEEQYEPPEKRTCHVKTKKINQFRILDDDDNDAGDKAVVEDEQKDLLAKTPE 349

  Fly   518 ---------------GRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKG- 566
                           ||..:  ..||||||.|::.||..||.|||::..:.|...||.||...|
  Fly   350 PEVFSSDEEEEHLSNGRYPS--ANTLVVCPMSVMCQWAHEVASKVAQNAIRVLTFHGPNRHEIGI 412

  Fly   567 KYLRDYDIVVTTYQIVAREHK---SLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRW 628
            :..|.||:|:|:|.:|..|.|   :.|.:|.|.|.|:||||||::||.|:....:||.||....|
  Fly   413 EAFRSYDLVITSYNLVVNELKRYGNTSPLFAVYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHW 477

  Fly   629 ALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAGGQNRLNLLMKSLMLRRTKAQLQS 693
            ||||||:||:.:||:|||:|:....|.||..|||.: |:|..|..|||.::|.|||||||.:||:
  Fly   478 ALTGTPVQNRGVDVFALLRFVNVPNFQDLQQWKKNL-NESMLGHRRLNFIIKPLMLRRTKQKLQA 541

  Fly   694 DGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQ 758
            .|.:.:||:.::.||.:.|.|.||.|||.:...|:.:|.|||.||.:..:|.||.|....|.:..
  Fly   542 SGDMPALPSLKIELICVQLSKTEMAVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIA 606

  Fly   759 IKDPNGAYYKMHEKFARMAGSK--KEVKSHDILVLLLRLRQICCHPGLIDAMLDG----EESQTM 817
            ....:..|.:::|:|.:..|..  :::....||||||||||.||||||:..||.|    |:.|.:
  Fly   607 GHMSDERYNEIYERFLKSLGYNPGEKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNV 671

  Fly   818 GDHSSDSDTP-EIDLLAQLNKLAITD-----------TSTDG------------QQSVA-NAGDD 857
            ...:||.:.. ::|:||:|:|...||           |..||            :::|. ::|||
  Fly   672 KVDASDVEGQLKMDVLAELDKFDETDSEDDCCDEEDSTRRDGNFKLEVIKDEIKEENVPWDSGDD 736

  Fly   858 GPPL--LPDEARIAKASKNLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSV 920
            .|..  ..|:...|:|.| ||...||:|...|||:|:.|||..|: .:|..::||.||.|||.|.
  Fly   737 LPTASSFEDQLDSARALK-LLNPQNPIFQFIRPSAKLKMVIDKLE-ELLTGTNDKIIVTSQWVSY 799

  Fly   921 LDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLL 985
            |.|:|..|......||..||.:..|.|:.::.:|| .||:|||||||||||||||||..|||:|:
  Fly   800 LAIVRKRLQDLSWETLDFNGQLTAKEREIVLRDFN-ANNEKRVLLLSLTAGGVGLNLNVANHMLI 863

  Fly   986 LDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVL--TGAKVS- 1047
            :|||||||||.||||||||.||.|...||::||.||||||||.|||.||::|..||  .|.:|:
  Fly   864 VDLHWNPQLERQAQDRIYRYGQTKPTFIYRYMCQDTVEQRIKSLQDCKLEIAKVVLPEEGGEVTK 928

  Fly  1048 ---SKLTIDDLKGLFGM 1061
               ..|.:.:||.||.|
  Fly   929 CVGGGLNLAELKKLFEM 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	SNF2_N	442..805	CDD:278600	166/445 (37%)
		DEXDc	459..634	CDD:238005	83/255 (33%)
		HELICc	885..1014	CDD:238034	72/128 (56%)
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	332/886 (37%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	118/327 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467134
Domainoid	1	1.000	180	1.000	Domainoid score	I1043
eggNOG	1	0.900	-	-		E1_COG0141
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	395	1.000	Inparanoid score	I1119
Isobase	1	0.950	-	0	Normalized mean entropy	S3486
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132523at2759
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	1	1.000	-	-		mtm1031
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45626
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2250
SonicParanoid	1	1.000	-	-		X1278
	12	11.880