DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lds and hltf

DIOPT Version :9

Sequence 1:	NP_524850.2	Gene:	lds / 45894	FlyBaseID:	FBgn0002542	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_004914419.1	Gene:	hltf / 394525	XenbaseID:	XB-GENE-494079	Length:	985	Species:	Xenopus tropicalis

Alignment Length:	831	Identity:	228/831 - (27%)
Similarity:	348/831 - (41%)	Gaps:	236/831 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   407 LTLESLK-DLHVSLEDLPGPEVLAE----DPVGLKVSLMNHQKHALAWMSWRE--RKLP------ 458
            :|.|.|| :.....|||...:...|    :.:|  ..|::|||.||:||..||  .:||
Frog   209 MTTEQLKTEFDKLFEDLKEDDKTQELEPAETIG--TQLLSHQKQALSWMVSRENTEELPPFWEER 271

  Fly   459 --------------------RGGILADDMGLGKTLTMISSVL----------------------- 480
                                |||||||||||||||::|:.:|
Frog   272 NHLYYNTLTNFAEKQKPENVRGGILADDMGLGKTLSVIALILTNFYDGRPFPTKKIKKQELAESD 336

  Fly   481 ------------ACKNGQEMSEGKDESS-----------------------DSDSEDD------- 503
                        |.|..:..::.:.||.                       .|.||:|
Frog   337 VLKSNMSQKQFKAAKKTELSTDSRKESETLSQEASSSRPKRQKARKTKYTYSSASEEDEAWLPRK 401

  Fly   504 -----------------------------KNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQW 539
                                         ||||..:|:...||...:.:|..||::||.|:|..|
Frog   402 VKAPAECTLHDDDLFANALFGLPTAVRKKKNKKGVTVSQSISKAGPEGQRRTTLIICPLSVLSNW 466

  Fly   540 ESEVESKVSRQ-KLTVCVHHGNNRETKGKYLRDYDIVVTTYQIVAREH--KSLSAVFGVKWRRII 601
            ..:.|..:..: .|.:.:::|..|....|.|.|.|:|||||.:::.::  :|.|.:..|||.|::
Frog   467 IDQFEQHIKPEVHLNIYIYYGPERTKDPKVLSDQDVVVTTYSVLSSDYGSRSESPLHKVKWLRVV 531

  Fly   602 LDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDN 666
            |||.|.:||..:|.:.||..|..:.||.||||||||...|:::|:.||:..||.|...|.:.|..
Frog   532 LDEGHTIRNPNAQQTQAVLSLEAQRRWILTGTPIQNSLKDLWSLICFLKLKPFTDREWWHRTIQR 596

  Fly   667 K----SAGGQNRLNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYS 727
            .    ..||..||..|:|::.|||||........:..||.:::.:..:.|.:||..:|:::....
Frog   597 PVTTGEDGGLCRLQALIKNITLRRTKTSKIRGRPVLDLPERKVFIQHVELSEEERQIYESLKNEG 661

  Fly   728 RTLFAQFLHQRAERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSH--DILV 790
            :.:.::::                                           |:..:.||  |:|.
Frog   662 KAVISRYV-------------------------------------------SEGTILSHYADVLA 683

  Fly   791 LLLRLRQICCHPGLIDAMLDG---EESQTMGD------------HSSDSDTPEIDLLAQLNKLAI 840
            :|:||||:||||.|:.:.|..   ....|.||            .||.||......|..||...|
Frog   684 VLVRLRQLCCHPFLVSSALSSITTTADSTPGDVREKLVQKIKLVLSSGSDEECAICLDSLNMPVI 748

  Fly   841 TDTS-----------TDGQQSVANAGDDGPPL------------LPDEARIAKASKNLLKRSNPV 882
            |..:           ...::..|..     ||            .|.|...:..:|.|.:.
Frog   749 TYCAHVFCKPCICQVIQHEKQEAKC-----PLCRGSLRLDQLVECPQEDLDSSINKKLEQN---- 804

  Fly   883 FNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNR 947
               ...|:|||.::..|.....|.:..|:|||||:||.|.::...|.:.|.....|:|::..|.|
Frog   805 ---WMCSTKINALMHALVDQRRKDATVKSIVVSQFTSFLSVIEVALRESGFMFTRLDGSMTQKKR 866

  Fly   948 QDIVNEFNDRNNQK-RVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNV 1011
            .:.:..|...:.|. .::||||.||||||||..|:.:.|:|..|||..|.|..||.:|:||.|.|
Frog   867 TEAIQSFQRPDAQSPTIMLLSLKAGGVGLNLTAASRVFLMDPAWNPAAEEQCFDRCHRLGQTKKV 931

  Fly  1012 IIYKFMCVDTVEQRIKGLQDKKLDLADGVLTGAKVSS----KLTIDDLKGL 1058
            |:.||:..::||:.:..:|.||.:||.|.....|.||    :..|:|::.|
Frog   932 IVTKFVVRNSVEENMLKIQSKKRELAAGAFGKKKSSSSQLKQARIEDIRTL 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	SNF2_N	442..805	CDD:278600	130/493 (26%)
		DEXDc	459..634	CDD:238005	74/271 (27%)
		HELICc	885..1014	CDD:238034	51/129 (40%)
hltf	XP_004914419.1	HIRAN	63..156	CDD:370129
		DEAD-like_helicase_N	244..620	CDD:391939	107/375 (29%)
		HepA	<453..962	CDD:223627	168/563 (30%)
		RAD18	736..>799	CDD:227719	10/67 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132523at2759
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010