Protein Alignment lds and Smarca2

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_001004446.2
• Gene: Smarca2 / 361745
• RGDID: 1302988
• Length: 1597
• Species: Rattus norvegicus
• Alignment Length: 1189
• Identity: 248/1189 - (20%)
• Similarity: 432/1189 - (36%)
• Gaps: 387/1189 - (32%)

  Fly    53 ETQSEEEESQSSETAESEKSDESDNSQNSQESEDSEDDSV-----RPS---------ARNTKRK- 102
            :.|.::::.|..:..:.::..:...:|..|:.:..:....     |||         |:||::|
  Rat   221 QQQQQQQQQQQQQPQQPQQPQQQTQAQPQQQQQQQQQPPALVSYNRPSGPGQELLMTAQNTQQKL 285

  Fly   103 ----PLGIPSDSEDEEDELEQRAL-SPSTRMSITG------------------VRPQDLSDDDSE 144
                |.|.||.:.....:....|: .||.:....|                  .:||.|  |..|
  Rat   286 SAPAPSGRPSPAPPAATQPTATAVPGPSVQQPAPGQPSPVLQLQQKQSRISPIQKPQGL--DPVE 348

  Fly   145 I----EYS---------DEVQEGPTEAP-------TAEAVVPRYTTQFAGNIQNDLHSTIGAA-- 187
            |    ||.         .|::..|...|       |.|....|..     |.|..|...:.|.
  Rat   349 ILQEREYRLQARIAHRIQELESLPGSLPPDLRTKATVELKALRLL-----NFQRQLRQEVVACMR 408

  Fly   188 DSEVLDDSSGSDVLILSNKETPIE--ILSSTDDDATTNKENMSGPPFERPSKSLSP--------- 241
            ....|:.:..|.....|.::|..|  :....:......:|.......:....|:..
  Rat   409 RDTTLETALNSKAYKRSKRQTLREARMTEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYH 473

  Fly   242 RSSAGASVVKTSKNLSQPTIQAVLKQKTSP---AAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKR 303
            ||.|| .:.|.||.::........:||...   ...|..|:.:||::...:::..::.|:|| ..
  Rat   474 RSVAG-KIQKLSKAVATWHANTEREQKKETERIEKERMRRLMAEDEEGYRKLIDQKKDRRLA-YL 536

  Fly   304 VQVSDAEKLFEKVA--------HKLPDKGSQIMKRIDTLRRELA-----------------MDEQ 343
            :|.:|     |.||        ||......:..||  ..||:.|                 :||.
  Rat   537 LQQTD-----EYVANLTNLVWEHKQAQAAKEKKKR--RRRRKKAEENAEGGEPALGPDGEPIDES 594

  Fly   344 WISALRVQQSNVPAVRVVKPT-------LNPPRAPSIDTLD-WDELSEAVNEIKPVYTGAQGMAT 400
                  .|.|::|    ||.|       |..|.||....|| |.|::... |:.|.....:..:.
  Rat   595 ------SQMSDLP----VKVTHTETGKVLFGPEAPKASQLDAWLEMNPGY-EVAPRSDSEESESD 648

  Fly   401 FNNQKALTLESLKDLHVSLEDLPGPEVLAE---------------DPVGLKVS------------ 438
            :..:......|.::....:...|..|.::|               |...::.|
  Rat   649 YEEEDEEEESSRQETEEKILLDPNSEEVSEKDAKQIIETAKQDVDDEYSMQYSARGSQSYYTVAH 713

  Fly   439 -----------------LMNHQKHALAWM-SWRERKLPRGGILADDMGLGKTLTMISSVLACKNG 485
                             |.::|...|.|| |.....|  .|||||:||||||:..|:.:......
  Rat   714 AISERVEKQSALLINGTLKHYQLQGLEWMVSLYNNNL--NGILADEMGLGKTIQTIALITYLMEH 776

  Fly   486 QEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWESEVES----- 545
            :.::                                   |..|::.|.|.|..|..|.:.
  Rat   777 KRLN-----------------------------------GPYLIIVPLSTLSNWTYEFDKWAPSV 806

  Fly   546 -KVS-------RQKLTVCVHHGNNRETKGKYLRDYDIVVTTYQIVAREHKSLSAVFGVKWRRIIL 602
             |:|       |:.|...:..|.           :::::|||:.:.::...|:.   ::|:.:|:
  Rat   807 VKISYKGTPAMRRSLVPQLRSGK-----------FNVLLTTYEYIIKDKHILAK---IRWKYMIV 857

  Fly   603 DEAHVVRNHKSQSSLAVCDLRGKY----RWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKW 663
            ||.|.::||..:.:..   |...|    |..|||||:|||..:::|||.||..:.|....|:::|
  Rat   858 DEGHRMKNHHCKLTQV---LNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQW 919

  Fly   664 IDNKSA-GGQ-------------NRLNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDK 714
            .:...| .|:             .||:.:::..:|||.|.:::|     .||.|...:|     |
  Rat   920 FNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVES-----QLPEKVEYVI-----K 974

  Fly   715 EEMNVYQTVMTYSRTLFAQFLHQRAE--RETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMA 777
            .:|:..|.::         :.|.:|:  ..||
  Rat   975 CDMSALQKIL---------YRHMQAKGILLTD--------------------------------- 997

  Fly   778 GSKKEVK----SHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKL 838
            ||:|:.|    :..::..:::||:||.||.:...:   |||  ..:|
  Rat   998 GSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHI---EES--FAEH------------------ 1039

  Fly   839 AITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFN---LHRPSSKINMVIQILK 900
                                                 |..||.|.|   |:|.|.|..::.:||.
  Rat  1040 -------------------------------------LGYSNGVINGAELYRASGKFELLDRILP 1067

  Fly   901 TSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLL 965
            .  |::::.:.::..|.||::.|:.|:.:......|.|:||...::|..::.:||:..:|..:.|
  Rat  1068 K--LRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFL 1130

  Fly   966 LSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQ 1030
            ||..|||:||||..|:.:::.|..|||..:.|||||.:|:||:..|.:.:...|::||::|....
  Rat  1131 LSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAA 1195

  Fly  1031 DKKLDLADGVLTGAKVSSK 1049
            ..||::...|:.......|
  Rat  1196 KYKLNVDQKVIQAGMFDQK 1214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	189/871 (22%)
		DEXHc_TTF2	439..686	CDD:350830	66/278 (24%)
Smarca2	NP_001004446.2	PHA03378	<74..389	CDD:223065	32/169 (19%)
		QLQ	173..207	CDD:462622
		HSA	443..515	CDD:214727	13/72 (18%)
		BRK	596..639	CDD:462196	15/47 (32%)
		DEXHc_SMARCA2	708..958	CDD:350821	68/303 (22%)
		PLN03142	727..>1209	CDD:215601	151/649 (23%)
		SnAC	1266..1333	CDD:464219
		Bromodomain	1340..>1426	CDD:445827
		Bromo_SNF2L2	1389..1513	CDD:99947