Protein Alignment lds and rad8

DIOPT Version :9

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_001342793.1
• Gene: rad8 / 3361391
• PomBaseID: SPAC13G6.01c
• Length: 1133
• Species: Schizosaccharomyces pombe
• Alignment Length: 1289
• Identity: 304/1289 - (23%)
• Similarity: 494/1289 - (38%)
• Gaps: 406/1289 - (31%)

  Fly     4 ENSE---YYSDKEEDSVVNNSSLGRS----RKSSRLSKSSRLSKSSRPS--SAGVVID------- 52
            |||.   :.||.|.||..|:.:...|    :.:|:...::...|....|  |...|:|
pombe    16 ENSPPRFFDSDVEADSKPNDLTAANSIVDLKTNSQHENANAAGKEYGDSGVSESWVLDFLSVTGE 80

  Fly    53 ETQSEEEESQSSETAESEKS-------DESDNSQNSQESEDSEDD---------------SVRPS 95
            :|.||....:..:|:..:.:       |||.|.:||....:|:.|               ||:..
pombe    81 KTISEFLAQKIWKTSNGDLNVAVDMYFDESFNIKNSNPDSESQKDTDASLTQMDQLSNTVSVKDL 145

  Fly    96 A--RNTKRKPLGIPSDSEDEEDELEQRALSPSTRMSITGVRPQDLSDDDSEIEYSDEVQEGPTEA 158
            :  |||.:|.|               .|:|||..:| :....||:|.|..|:          .:.
pombe   146 SINRNTNKKAL---------------NAVSPSLNLS-SNSSVQDVSIDKEEM----------MKK 184

  Fly   159 PTAEAVVPRYTTQFAGNIQNDLHSTIGAADSEVLDDSSGSDVL------ILSNKETPIEILSSTD 217
            .:..|:.|   ..|... :|:|...||....|....:||:..|      .|..::..|:..|...
pombe   185 QSRNALTP---LDFIMK-KNELMKYIGCFGVEAYSTASGTRTLQAGERIYLERQKLSIKSQSRNS 245

  Fly   218 DDATTNKENMSGPPFERPSKSLSPRSSAGASVVKTSKNLSQPTIQAVLKQKTSPAAPRRSRIKSE 282
                           .:.||.||..||..:::|:.. |.....|               .::.:|
pombe   246 ---------------RKKSKLLSINSSCYSNIVRFC-NSDHHEI---------------GKLPTE 279

  Fly   283 DQKVVSQV------------VYDEEMRKLAEK-RVQVSDAEKLFEKVAHKLPDKGSQIMKRIDTL 334
            ...|:|.:            :|.:.:.:.... .:||    ..|..|.|...:: |......:::
pombe   280 VASVISTLMEQGFWSFEAICIYSDNIIRFGSNVTLQV----YCFINVNHPSLNR-SPFTLATNSM 339

  Fly   335 RRELAMDEQWISALRVQQSNVPAVRV-----VKPTL---NPPRAPSI-DTLDWDELSEAVNE--- 387
            :.|    |:.:.|...|......:|:     ::|.|   |...:..| |.|....|.||.:|
pombe   340 QEE----EEHLKASFAQNKRDHLLRLFTWIALEPDLEDCNTKESIHIDDILKTSSLPEARDESNS 400

  Fly   388 -IKPVYTGAQGMATFNNQKALTLESLKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAWMS 451
             :.|..|..: ....::|.|:..:.:|.....|...|.|...|.|       |..:||.||.||.
pombe   401 DLTPSSTEDE-EDVVSDQLAILYDKVKTSGAELPSAPKPSTFALD-------LREYQKQALYWMC 457

  Fly   452 ------------------WRERKLP---------------------------------------- 458
                              |...:.|
pombe   458 CKEEGVQSDGSAPKLHPLWSRFRFPKDSEFPEFFKCSSDDDNTHFYVNLYTGETTMLFPNSMPYH 522

  Fly   459 RGGILADDMGLGKTLTMISSVLA--CKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKD 521
            |||||||:||||||:.::|.:.:  |.:..|:.|....|..|.....:.
pombe   523 RGGILADEMGLGKTIEVLSLIHSRPCFSTDEIPEAFRHSKPSLPVASRT---------------- 571

  Fly   522 TRRGGTLVVCPASLLRQWESEVESKVSR-QKLTVCVHHGNNR---------ETKGKYLRDYDIVV 576
                 ||||.|.|||.||.||. .|||: .|....:::|:.:         :|....|    |::
pombe   572 -----TLVVAPMSLLDQWHSEA-CKVSQGTKFRSMIYYGSEKPLDLKSCVIDTSTAPL----III 626

  Fly   577 TTYQIVARE---HKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNK 638
            |:|.::..|   ....|.:|.|.|.|::|||.|.:||.:|:::.|...:..:.||.:|||||.||
pombe   627 TSYGVLLSEFSQQSHSSGLFSVHWFRVVLDEGHNIRNRESKTAKACHSISSQNRWVITGTPIVNK 691

  Fly   639 ELDVYALLKFLRCSPFDDLHTWKKWID--NKSAGGQNRLNL---LMKSLMLRRTKAQLQSDG-KL 697
            ..|:|:|:||:|..|:.:...|:.::.  .:|......||:   :::.|:|||||.....:| .:
pombe   692 LDDLYSLIKFMRYEPWCNYTYWQTFVSLPYQSKDVLKALNVVQSILEFLVLRRTKETKDRNGNSI 756

  Fly   698 NSLPNKELRLIEISLDKEEMNVYQTVMTYSR----------TLFAQFLHQRAERETDFNYRSDAN 752
            .:||.|.:::..:.....|..:|.::.|.::          |||.             ||.:
pombe   757 VTLPPKTVKIEYLDFSDSERKIYDSLYTKAKSTVNANIVAGTLFR-------------NYTT--- 805

  Fly   753 KPTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTM 817
                                               ||.|||||||.||.|.|:..|.  ..|:|.
pombe   806 -----------------------------------ILGLLLRLRQACCDPVLLSNMT--INSETF 833

  Fly   818 GDHSSD-------------------SDTPEIDLLAQLNKLAITDTSTDGQQSVAN---------- 853
            .|....                   ||..:||.|.....| ||:......:.:.|
pombe   834 DDFEFSVEQFNSLINQFVVTGKPIPSDILKIDTLKSFEAL-ITECPICCNEPIQNPLLLNCKHAC 897

  Fly   854 AGDDGPPLLPDEARIAKASKNLLKRSNPV-------FN---LHRP-------------------- 888
            .||    .|.:..:..| .:|::.   |:       ||   :::|
pombe   898 CGD----CLSEHIQYQK-RRNIIP---PLCHTCRQPFNEQDVYKPFFVKNNGTQSTLLVGEEVKW 954

  Fly   889 -------SSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKN 946
                   |.|:|.::..|:.....|..:|.::.||:|:.|||:.|.|..:.:.....:||:..:.
pombe   955 KYWNRLQSVKLNGLLGQLRQLTHSSEPEKVVIFSQFTTFLDIIADVLESEKMGYARFDGTMSQQM 1019

  Fly   947 RQDIVNEFNDRNN-QKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKN 1010
            |...:..|  ||: ...||::||.||||||||..|||:.::|..|:..:||||.|||:|:||:|.
pombe  1020 RSTALETF--RNDPDVNVLIISLKAGGVGLNLTCANHVFIMDPWWSWSVEAQAIDRIHRLGQEKP 1082

  Fly  1011 VIIYKFMCVDTVEQRIKGLQDKKLDLADGVLTGAKVSSK-----LTIDDLKGLF 1059
            |.:.:::..||||:|:..:|::|     ..:||....|:     .:|:|:|.||
pombe  1083 VFVTRYIVRDTVEERMLKIQERK-----NFITGTLGMSEGKQQVQSIEDIKMLF 1131

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	SNF2_N	442..805	CDD:278600	113/451 (25%)
		DEXDc	459..634	CDD:238005	59/189 (31%)
		HELICc	885..1014	CDD:238034	50/156 (32%)
rad8	NP_001342793.1	HIRAN	209..316	CDD:214906	20/137 (15%)
		HepA	<521..1133	CDD:223627	192/706 (27%)
		RING-HC_SpRad8_like	874..923	CDD:319486	9/56 (16%)
		RING-HC finger (C3HC4-type)	877..922	CDD:319486	7/52 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	169	1.000	Domainoid score	I905
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	1	1.000	-	-		otm47368
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2250
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940