Protein Alignment lds and Chd1

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_001245851.1
• Gene: Chd1 / 33505
• FlyBaseID: FBgn0250786
• Length: 1900
• Species: Drosophila melanogaster
• Alignment Length: 1133
• Identity: 252/1133 - (22%)
• Similarity: 426/1133 - (37%)
• Gaps: 284/1133 - (25%)

  Fly     3 SENSEYYSDKEEDSVVNNSSLGRSRKSSRLSKSSRLSKSSRPSSAGVVIDETQSEEEESQSSETA 67
            |..|:..||.|..|...|.|:..:..||.|.|..:..:....:.||          ::..:|:.:
  Fly   116 SSGSDSDSDAEGPSDQRNQSINNANTSSSLPKPEQNEEEDNETEAG----------QQQPASDAS 170

  Fly    68 ESEKSDESDN---SQNSQESEDSEDDSVRPSARNTKRKPLGIPSDSEDEEDELEQRALSPSTRMS 129
            ..|.||.|.|   :.:|..||:.|:| .||......|||   |:.:|.     .::|.:|..:..
  Fly   171 ADESSDSSANVSPTSSSSSSEEEEED-YRPKRTRQARKP---PTAAEK-----SKKAPAPKNKKK 226

  Fly   130 ITGVRPQDLSDDDSEIEYSDEVQEGPTEAPTAEAVVPRYTTQFAGNIQNDLHSTIGAADSEVLDD 194
            ...      ||:..|.|.||:      |..||:...|..||..:...|......:....||..||
  Fly   227 TWD------SDESDESEDSDD------EVSTAQKRKPAATTSRSKLAQQQQRRRVKPFSSEDSDD 279

  Fly   195 SSGSDVLILSNKETPIEILSSTDDDATTNKENMSGPPFERPSKSLSPRSSAGASVVKTSKNLSQP 259
            ...|.......|...:....:::|:||.:::.:.   ||      ...|.|..:.....:.....
  Fly   280 DDASKRCATRRKGAAVSYKEASEDEATDSEDLLE---FE------YDESQAATTAATAEEEEKCE 335

  Fly   260 TIQAVLKQKTSP--AAPRRSRIKS-EDQKVVSQVVYDEEMRKLAEKRVQV-------SDAEKLFE 314
            ||:.:|.|:...  ....::.|.: |:........:||:....||...|.       |.....:|
  Fly   336 TIERILAQRAGKRGCTGNQTTIYAIEENGFDPHAGFDEKQTPDAETEAQFLIKWKGWSYIHNTWE 400

  Fly   315 KVAHKLPDKGSQIMKRIDTLRRELAMDEQW--------ISALRVQ----------QSNVPAVRVV 361
            ..| .|.|..::.||::|...::......|        |.....|          .:||.  |::
  Fly   401 SEA-TLRDMKAKGMKKLDNFIKKEKEQAYWRRYAGPEDIDYFECQLELQHELLKSYNNVD--RII 462

  Fly   362 KPTLNPPRAPSIDTLDWDELSEAVN---EIKPVYTGAQGMA-TFNNQKALTLESLKDLHVSLEDL 422
            .....|..........|..|..|.:   :...|....|..| .||::::......:...| ::..
  Fly   463 AKGSKPDDGTEEYLCKWQSLPYAESTWEDAALVLRKWQRCAEQFNDRESSKCTPSRHCRV-IKYR 526

  Fly   423 P-------GPEVLAEDPVGLKVSLMNHQKHALAWM--SW-RERKLPRGGILADDMGLGKTLTMIS 477
            |       .||.|:.   ||  :|.::|...|.|:  || :|..:    ||||:||||||:..|.
  Fly   527 PKFSRIKNQPEFLSS---GL--TLRDYQMDGLNWLLHSWCKENSV----ILADEMGLGKTIQTIC 582

  Fly   478 SVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWESE 542
            .:.:......:                                   .|..|.|.|.|.:..|:.|
  Fly   583 FLYSLFKIHHL-----------------------------------YGPFLCVVPLSTMTAWQRE 612

  Fly   543 VESKVSRQKLTVCVHHGNNRE---------TKGKYLRDYDIVVTTYQIVAREHKSLSAVFGVKWR 598
            .:.......:...:....:||         ...|.|: ::.::|||:||.::.:.|..   ::|.
  Fly   613 FDLWAPDMNVVTYLGDIKSRELIQQYEWQFESSKRLK-FNCILTTYEIVLKDKQFLGT---LQWA 673

  Fly   599 RIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKW 663
            .:::||||.::|..|....::.:....:|..:||||:||...:::|||.|:....||   ||:.:
  Fly   674 ALLVDEAHRLKNDDSLLYKSLKEFDTNHRLLITGTPLQNSLKELWALLHFIMPDKFD---TWENF 735

  Fly   664 ---IDNKSAGGQNRLNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMT 725
               ..|....|..||:..::..:|||.|..::     .|||.|..:::.:.:...:...|:.::|
  Fly   736 EVQHGNAEDKGYTRLHQQLEPYILRRVKKDVE-----KSLPAKVEQILRVEMTSLQKQYYKWILT 795

  Fly   726 YSRTLFAQFLHQRAERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILV 790
                                                         :.|..:...|:...| ..|.
  Fly   796 ---------------------------------------------KNFDALRKGKRGSTS-TFLN 814

  Fly   791 LLLRLRQICCHPGLIDAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAG 855
            :::.|::.|.|..||..    .|.:.||
  Fly   815 IVIELKKCCNHAALIRP----SEFELMG------------------------------------- 838

  Fly   856 DDGPPLLPDEARIAKASKNLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSV 920
                 |..||     |.:.|||          .|.|:.::.::|  ..||.:..:.::.||...:
  Fly   839 -----LQQDE-----ALQTLLK----------GSGKLVLLDKLL--CRLKETGHRVLIFSQMVRM 881

  Fly   921 LDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLL 985
            ||:|.|:|.|.......|:|:|..:.|:..::.||...:|....|||..|||:|:||..|:.:::
  Fly   882 LDVLADYLQKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVII 946

  Fly   986 LDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVL-----TGAK 1045
            .|..||||.:.|||.|.:|:|||..|.||:.:...:||::|.....:|:.|...|:     ||..
  Fly   947 FDSDWNPQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMDTTGRT 1011

  Fly  1046 V-----------SSKLTIDDLKGL--FG 1060
            |           |:....|||..:  ||
  Fly  1012 VLDKSGNGHSSNSNPFNKDDLSAILKFG 1039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	176/804 (22%)
		DEXHc_TTF2	439..686	CDD:350830	62/261 (24%)
Chd1	NP_001245851.1	CD1_tandem_CHD1-2_like	339..421	CDD:349313	17/82 (21%)
		CD2_tandem	454..508	CDD:349306	11/55 (20%)
		PLN03142	531..>1066	CDD:215601	156/674 (23%)
		CDH1_2_SANT_HL1	1205..1298	CDD:465731
		DUF4208	1521..1610	CDD:464035