Protein Alignment lds and Chd7

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_001264078.1
• Gene: Chd7 / 320790
• MGIID: 2444748
• Length: 2986
• Species: Mus musculus
• Alignment Length: 1096
• Identity: 234/1096 - (21%)
• Similarity: 400/1096 - (36%)
• Gaps: 348/1096 - (31%)

  Fly    25 RSRKSSRLSKSSRLSKSSRPSSAGVVIDETQSEEEESQSSETAESEKSDESDNSQNSQESEDSED 89
            :.:|..:..|:.::.|..:...|..|..:.:|.::.|.....:|:....:..|...::.||:|:.
Mouse   653 KEKKEPKTPKAPKIPKEPKEKKAKTVTPKPKSSKKSSNKKPDSEASALKKKVNKGKTEGSENSDL 717

  Fly    90 DSVRPSARNTKRKPLGIPSDSEDEEDELEQRALSPSTRMSITGVRPQDLSDDDSEIEYSDEVQEG 154
            |...|.:          |:..|||:..:::|..|...:        :....:|.|.:.|||
Mouse   718 DKTPPPS----------PAPEEDEDPGVQKRRSSRQVK--------RKRYTEDLEFKISDE---- 760

  Fly   155 PTEAPTAEAVVPRYTTQFAGNIQNDLHSTIGAADSEVLDDSSGSDVLILSNKETPIEILSSTDDD 219
              ||..|:|                                        :.:::|    |:|...
Mouse   761 --EADDADA----------------------------------------AGRDSP----SNTSQS 779

  Fly   220 ATTNKENMSGPPFER--PSKSLSPRSSAGASV------VKTSKNLSQ-----PTIQAVLKQKTSP 271
            ......:..||..|:  .|:.:..:..:|..|      || .||.|.     .:::.:.|.|...
Mouse   780 EQQESVDAEGPVVEKIMSSRLVKKQKESGEEVEVEEFYVK-YKNFSYLHCQWASVEDLEKDKRIQ 843

  Fly   272 AAPRRSRIKSEDQKVVSQVVYD------EEMRKLAEKRVQVSDAEKLFEKVAHKLPDKGSQIMKR 330
            ...:|.:.|....|.:|::..|      .|:.::.:......|..   |.|.|.|. |...:...
Mouse   844 QKIKRFKSKQGQSKFLSEIEDDLFNPDYVEVDRIMDFARSTDDRG---EPVIHYLV-KWCSLPYE 904

  Fly   331 IDTLRRELAMDEQWISALRVQQSNVPAV-RVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTG 394
            ..|...:..:|:..|.......|..|.. ||.:|..:          ||.: ||:..|.|
Mouse   905 DSTWELKQDIDQTKIEEFEKLMSREPETERVERPPAD----------DWKK-SESSREYK----- 953

  Fly   395 AQGMATFNNQKALTLESLKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAWM--SWRERKL 457
                   ||.|                                 |..:|...:.|:  :|...
Mouse   954 -------NNNK---------------------------------LREYQLEGVNWLLFNWYNM-- 976

  Fly   458 PRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDT 522
             |..||||:||||||:..|:.:...                                ..||
Mouse   977 -RNCILADEMGLGKTIQSITFLYEI--------------------------------YLKG---- 1004

  Fly   523 RRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGN------------------NRETKGKYL 569
            ..|..||:.|.|.:..||.|..:..   :|.|.|:||:                  .|..||.|
Mouse  1005 IHGPFLVIAPLSTIPNWEREFRTWT---ELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSY- 1065

  Fly   570 RDYDIVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVV--RNHKSQSSLAVCDLRGKYRWALTG 632
             .:..::||::::..:...|.   .:.||.:::||||.:  ||.|....|.:.||  :::..|||
Mouse  1066 -KFHAIITTFEMILTDCPELR---NIPWRCVVIDEAHRLKNRNCKLLEGLKMMDL--EHKVLLTG 1124

  Fly   633 TPIQNKELDVYALLKFLRCSPFDDLHTW-KKWIDNKSAGGQNRLNLLMKSLMLRRTKAQLQSDGK 696
            ||:||...::::||.||..|.|....|: :::.|.|:.....:|..::|.:||||.|..::
Mouse  1125 TPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVE---- 1185

  Fly   697 LNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQIKD 761
             .:|..||..:||:.|...:...|:.::                 |.:|.:.|...    .|...
Mouse  1186 -KNLAPKEETIIEVELTNIQKKYYRAIL-----------------EKNFTFLSKGG----GQANV 1228

  Fly   762 PNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGD--HSSDS 824
            ||                        :|..::.||:.|.||.||    :|.|.:.:.:  .:.::
Mouse  1229 PN------------------------LLNTMMELRKCCNHPYLI----NGAEEKILEEFKETHNA 1265

  Fly   825 DTPEIDLLAQL---NKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLH 886
            ::|:..|.|.:   .||.:.|                 .|||.
Mouse  1266 ESPDFQLQAMIQAAGKLVLID-----------------KLLPK---------------------- 1291

  Fly   887 RPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIV 951
                             ||:...:.::.||....||||.|:|.:.......::|.:....||..:
Mouse  1292 -----------------LKAGGHRVLIFSQMVRCLDILEDYLIQRRYPYERIDGRVRGNLRQAAI 1339

  Fly   952 NEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKF 1016
            :.|:..::.:.|.||...|||:|:||..|:..::.|..||||.:.|||.|.:|:||.|:|.||:.
Mouse  1340 DRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRL 1404

  Fly  1017 MCVDTVEQRIKGLQDKKLDLADGVL----------TGAKVSSKLTIDDL--KGLFG 1060
            :..::.|:.:......||.|...||          .|.:..||..|:||  ||.:|
Mouse  1405 ITRNSYEREMFDKASLKLGLDKAVLQSMSGRENATNGVQQLSKKEIEDLLRKGAYG 1460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	175/788 (22%)
		DEXHc_TTF2	439..686	CDD:350830	70/269 (26%)
Chd7	NP_001264078.1	Glutenin_hmw	<23..553	CDD:367362
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	93..146
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..180
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..246
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..307
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	372..412
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	461..792		34/206 (17%)
		CD1_tandem_CHD5-9_like	786..850	CDD:349315	14/64 (22%)
		CD2_tandem_CHD5-9_like	869..926	CDD:349310	10/60 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	928..949		8/31 (26%)
		PLN03142	957..>1556	CDD:215601	161/696 (23%)
		DEAH box	1095..1098		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1566..1590
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1826..1851
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2151..2274
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2366..2393
		BRK	2552..2593	CDD:462196
		BRK	2631..2675	CDD:197800
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2812..2861
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2924..2986