Protein Alignment lds and Ercc6

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_001074690.1
• Gene: Ercc6 / 319955
• MGIID: 1100494
• Length: 1481
• Species: Mus musculus
• Alignment Length: 1152
• Identity: 248/1152 - (21%)
• Similarity: 431/1152 - (37%)
• Gaps: 288/1152 - (25%)

  Fly     1 MSSENSEYYSDKEEDSVVNNSSLGRSRKSSRLSKSSRLSKSSRPSSA--------GV-VIDETQS 56
            :||.:.||......::.|    |..:|:...|....|....:...||        || |.|:...
Mouse    45 LSSTSCEYGPSTSAEACV----LAATRRGPTLLHIDRHQIPAVEPSAQALELQGLGVDVYDQAVL 105

  Fly    57 EEEESQSSETAESEKSDESDNSQNSQESEDSEDD------SVR----------PSA---RNTKRK 102
            |:...|..::|..|.|..:..:...:|.:...||      |:|          |.|   |:..||
Mouse   106 EQGVLQQVDSAMHEASCVAQLADAEKEYQSVLDDLMSCTTSLRQINKIIEQLSPQAASNRDINRK 170

  Fly   103 PLGIPSDSEDEEDELEQRALSPSTRMSITGVRPQDLSDDDSEIEYSDEVQEGPTEAPTAEAVVPR 167
            ...:.....::|.:|::.........:|.|.....:..|.:.:| .|:.:.||  :.....::|.
Mouse   171 LDSVKRQKYNKEQQLKKITAKQKRLQAILGGAGVQVELDHASLE-EDDAEPGP--SCLGSMLMPA 232

  Fly   168 YTTQFAGNIQNDLHSTIGAADSE---------VLDDSSGSDVLILSNKETPIEILSSTDDDATTN 223
            ..|.:...|:....:..|....:         :|:::||.:..:....:     ||
Mouse   233 QETAWEELIRTGQMTPFGTPAPQKQEKKPRKIMLNEASGFEKYLAEQAQ-----LS--------- 283

  Fly   224 KENMSGPPFERPSKSLSPRSSAGASVVKTSKNLSQPTIQAVLKQKTSPAAPRRSRIKSEDQKVVS 288
                    |||..::.:.|::..|.|:..|   |:..|:....|::...:....|:|...:|:..
Mouse   284 --------FERKKQAATKRTAKKAIVISES---SRAAIETKADQRSQVLSQTDKRLKKHSRKLQR 337

  Fly   289 QVV--------------YDEEMRKLAEKRVQVSDAEKLFEKVAHKLPDKGSQIMKRIDTLRRELA 339
            :.:              .:.|:|..||     .|.|.         .:.||   ...|....|..
Mouse   338 RALQFQGKVGLPSGKKPLEPEVRPEAE-----GDTEG---------EESGS---SPTDGEEEEEQ 385

  Fly   340 MDEQWISALRVQQSNVPAVRVVKPTLNPPRAP--SIDTLDWDELSEAVNEIKPVYTGAQGMA--- 399
            .:|:.:::|.....:.....:.|......:.|  .||. |:...||..:|......|.:.:|
Mouse   386 EEEEGVASLSSDDVSYELKPLRKRQKYQKKVPVQEIDD-DFFPSSEEEDEAMEGRGGGRKVARRQ 449

  Fly   400 -----TFNNQK-----ALTLESLKDLHVSLEDLPGPEVLAEDPVGLKV------SLMNHQKHALA 448
                 .:..|:     .|.|:. |:..:.||| ...|..||...|.||      .|..:|:..:.
Mouse   450 DDGDEDYYKQRLRRWNRLRLQD-KEKRLKLED-DSEESDAEFDEGFKVPGFLFKKLFKYQQTGVR 512

  Fly   449 WMSWRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTG 513
            |: |.......||||.|:||||||:.:|:.:......:..:.|                    :.
Mouse   513 WL-WELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKIRTRG--------------------SN 556

  Fly   514 WKSKGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKYLRD----YDI 574
            ::.:|     .|.|::|||.:::.||..|..:.....::.|....|:....|.:.:||    :.:
Mouse   557 YRFEG-----LGPTIIVCPTTVMHQWVKEFHTWWPPFRVAVLHETGSYTHKKERLIRDIVYCHGV 616

  Fly   575 VVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKE 639
            ::|:|..:......:|.   ..|..:||||.|.:||..:..:||....|..:|..|:|:|:||..
Mouse   617 LITSYSYIRLMQDDISR---HDWHYVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNL 678

  Fly   640 LDVYALLKFLRCSPFDDLHTWKKWIDNK-SAGGQNR---------------LNLLMKSLMLRRTK 688
            .::::|..|:.......|..:.:..... :.||.:.               |...:...:|||.|
Mouse   679 RELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMK 743

  Fly   689 AQLQSDGKLN-SLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDAN 752
                ||.|:: |||:|..:::...|..|:..|||..:
Mouse   744 ----SDVKMSLSLPDKNEQVLFCRLTDEQHKVYQNFI---------------------------- 776

  Fly   753 KPTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTM 817
                    |....|        |:...:.::.|.     |:.||:||.||.|.
Mouse   777 --------DSKAVY--------RILNGENQIFSG-----LVALRKICNHPDLF------------ 808

  Fly   818 GDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPV 882
                  |..|:                        ||  .|||  .||.            ....
Mouse   809 ------SGGPK------------------------NA--SGPP--EDEL------------EEEQ 827

  Fly   883 FNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNR 947
            |...|.|.|:.:|..:||  |......:.::.||...:|.||...|.....:.|.::||..:.:|
Mouse   828 FGHWRRSGKMIVVESLLK--IWHRQGQRVLLFSQSRQMLHILEVFLRAHKYSYLKMDGTTTIASR 890

  Fly   948 QDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVI 1012
            |.::.::|: :....|.||:...||:|:||.|||.:::.|..|||..:.||::|.:|:||||.|.
Mouse   891 QPLITKYNE-DTSIFVFLLTTRVGGLGVNLTGANRVIIYDPDWNPSTDTQARERAWRIGQKKQVT 954

  Fly  1013 IYKFMCVDTVEQRIKGLQDKKLDLADGVLTGAKVSSKLTIDDLKGLF 1059
            :|:.:...|:|::|...|..|..|.:.||...|.......:||..||
Mouse   955 VYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQRRFFKSNDLYELF 1001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	180/809 (22%)
		DEXHc_TTF2	439..686	CDD:350830	58/266 (22%)
Ercc6	NP_001074690.1	N-terminal domain, essential for its chromatin remodeling activity. /evidence=ECO:0000250|UniProtKB:Q03468	1..506		97/512 (19%)
		cc_ERCC-6_N	83..159	CDD:411064	16/75 (21%)
		46	<122..>199	CDD:222878	12/76 (16%)
		HepA	280..983	CDD:440319	195/890 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..452		27/160 (17%)
		DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	642..645		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1040..1096
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1114..1238
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1307..1372
		CSA-interacting motif (CIM). /evidence=ECO:0000250|UniProtKB:Q03468	1373..1385
		Ubiquitin-binding domain (UBD). /evidence=ECO:0000250|UniProtKB:Q03468	1387..1416
		CSB_WHD	1410..1480	CDD:439329
		Winged-helix domain (WHD). /evidence=ECO:0000250|UniProtKB:Q03468	1417..1481
		Essential for its interaction with RNA polymerase II, transcription-coupled nucleotide excision repair activity, association with chromatin after UV irradiation and for mediating the UV-induced translocation of ERRC8 to the nuclear matrix. /evidence=ECO:0000250|UniProtKB:Q03468	1434..1481