Protein Alignment lds and Ercc6l

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_001092144.1
• Gene: Ercc6l / 317252
• RGDID: 1565734
• Length: 1230
• Species: Rattus norvegicus
• Alignment Length: 818
• Identity: 180/818 - (22%)
• Similarity: 313/818 - (38%)
• Gaps: 245/818 - (29%)

  Fly   284 QKVVSQVVYDEEMRKLAEKRVQVSDAEKLFEKVAHKLPDKGSQIMKRIDTLR---RELAMDEQWI 345
            |...|.:.|.:|.:: |.|...:.:|.|||.......|.|  :::.||..|:   .:||.:|.
  Rat    16 QLAESYLRYSQEAKE-AAKNGDLEEALKLFNLAKDIFPTK--KVISRIQKLQEALEQLAEEED-- 75

  Fly   346 SALRVQQSNVPAVRVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTGAQGMATFNNQKALTLE 410
                                             ||.::..|         .|:..:..
  Rat    76 ---------------------------------DEFTDVCN---------SGLLLYRE------- 91

  Fly   411 SLKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAWMSWRERKLPRGGILADDMGLGKTLTM 475
                                    |...|..|||..:|::....:...:|||||||||||||:.:
  Rat    92 ------------------------LYEKLFEHQKEGIAFLYSLYKNGRKGGILADDMGLGKTVQI 132

  Fly   476 ISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWE 540
            |:.:....:...::.                                    .|::.|.:|:..|.
  Rat   133 IAFLSGMFDASLVNH------------------------------------VLLIMPTNLINTWV 161

  Fly   541 SEVESKVSRQKLTVCVHHGNNRETKGKYL----RDYDIVVTTYQIVAREHKSLSAVFG--VKWRR 599
            .|........:  |...||:::..:.:.|    :...:|:||||::....:.|::..|  ..|..
  Rat   162 KEFAKWTPGMR--VKTFHGSSKNERIRNLTRIQQRNGVVITTYQMLLNNWQQLASFNGQAFVWDY 224

  Fly   600 IILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRC--SPFDDLHTWKK 662
            :||||||.:::..::|::....:....|..||||||||...::::|..| .|  |....|.|:|.
  Rat   225 VILDEAHKIKSASTKSAVCARAVPASNRLLLTGTPIQNNLQELWSLFDF-ACQGSLLGTLKTFKM 288

  Fly   663 WIDN--------------KSAGGQNRLNL--LMKSLMLRRTKAQL---QSD------GKLNSLPN 702
            ..:|              |:.|.:...||  ::|...|||||.::   ::|      |:.||...
  Rat   289 EYENPIIRAREKDATPGEKALGFKMSENLMEIIKPYFLRRTKEEVHMKKADKPEVRPGEKNSGVE 353

  Fly   703 KELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQIKDPNGAYY 767
            ....::.:: .|.::.|:..::.....::.:|:            ..|..|....:.:.|
  Rat   354 DICEMLSLT-RKNDLIVWIRLVPLQEEIYRKFV------------SLDHIKELLMETRSP----- 400

  Fly   768 KMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSSDSDTPEIDLL 832
                                 |..|..|:::|.||.|:.|         ...|           |
  Rat   401 ---------------------LAELGVLKKLCDHPRLLSA---------RACH-----------L 424

  Fly   833 AQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRPSSKINMVIQ 897
            ..|..:..:....:.|:..:|.|.           |...|.|.|.:.         |.|:..::.
  Rat   425 LNLGTVTFSAEDENEQEDASNMGS-----------IDHLSDNALMQE---------SGKMIFLMA 469

  Fly   898 ILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIP-VKNRQDIVNEFNDRNNQK 961
            :|:.  |:....:.:|.||...:|:|:...|......||.::||:. :..|:..:..| .:|.:.
  Rat   470 LLER--LQDEGHQTLVFSQSRQILNIIERLLKNKHFKTLRIDGTVTHLWEREKRIQLF-QQNKEY 531

  Fly   962 RVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRI 1026
            .|.||:...|||||.|..|:.:::.|..|||..:|||.||:||:|||:||::|:.:...|||::|
  Rat   532 SVFLLTTQVGGVGLTLTAASRVVIFDPSWNPATDAQAVDRVYRIGQKENVVVYRLITCGTVEEKI 596

  Fly  1027 KGLQDKKLDLADGVL---TGAKVS--SKLTIDDLKGLF 1059
            ...|..|    |.::   ||.|.:  ...|..:||.||
  Rat   597 YRRQVFK----DSLIRQTTGDKKNPFRYFTKQELKELF 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	171/790 (22%)
		DEXHc_TTF2	439..686	CDD:350830	66/270 (24%)
Ercc6l	NP_001092144.1	HepA	<95..612	CDD:440319	149/641 (23%)
		DEXHc_ERCC6L	96..328	CDD:350759	66/270 (24%)