Protein Alignment lds and Chd7

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_001101376.2
• Gene: Chd7 / 312974
• RGDID: 1311921
• Length: 2985
• Species: Rattus norvegicus
• Alignment Length: 1104
• Identity: 240/1104 - (21%)
• Similarity: 399/1104 - (36%)
• Gaps: 364/1104 - (32%)

  Fly    25 RSRKSSRLSKSSRLSKSSRPSSAGVVIDETQSEEEESQSSETAESEKSDESDNSQNSQESEDSED 89
            |.:|..:..|:.:..|..:...|..|..:.:|.::.|.....:|:....:..|...::.||:|:.
  Rat   652 REKKEPKTPKAPKTPKEPKERKAKTVTPKPKSSKKSSNKKPDSEASALKKKVNKGKTEGSENSDL 716

  Fly    90 DSVRPSARNTKRKPLGIPSDSEDEEDELEQRALSPSTRMSITGVRPQDLSDDDSEIEYSDEVQEG 154
            |...|.:          |...|||:..:::|..|...:        :....:|.|.:.|||
  Rat   717 DKTPPPS----------PGPEEDEDPGVQKRRSSRQVK--------RKRYTEDLEFKISDE---- 759

  Fly   155 PTEAPTAEAVVPRYTTQFAGNIQNDLHSTIGAADSEVLDDSSGSDVLILSNKETPIEILSSTDDD 219
              ||..|:|                                        :.:::|    |:|...
  Rat   760 --EADDADA----------------------------------------AGRDSP----SNTSQS 778

  Fly   220 ATTNKENMSGPPFER--PSKSLSPRSSAGASV------VKTSKNLSQ-----PTIQAVLKQKTSP 271
            ......:..||..|:  .|:.:..:..:|..|      || .||.|.     .:::.:.|.|...
  Rat   779 EQQESVDAEGPVVEKIMSSRLVKKQKESGEEVEVEEFYVK-YKNFSYLHCQWASVEDLEKDKRIQ 842

  Fly   272 AAPRRSRIKSEDQKVVSQVVYD------EEMRKLAEKRVQVSDAEKLFEKVAH------KLPDKG 324
            ...:|.:.|....|.:|::..|      .|:.::.:......|..   |.|.|      .||.:.
  Rat   843 QKIKRFKSKQGQSKFLSEIEDDLFNPDYVEVDRIMDFARSTDDRG---EPVTHYLVKWCSLPYED 904

  Fly   325 SQIMKRIDTLRRELAMDEQWISALRVQQSNVPAV-RVVKPTLNPPRAPSIDTLDWDELSEAVNEI 388
            |....|.|       :|:..|.......|..|.. ||.:|..:          ||.: ||:..|.
  Rat   905 STWELRQD-------LDQAKIEEFEKLMSREPETERVERPPAD----------DWKK-SESSREY 951

  Fly   389 KPVYTGAQGMATFNNQKALTLESLKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAWM--S 451
            |            ||.|                                 |..:|...:.|:  :
  Rat   952 K------------NNNK---------------------------------LREYQLEGVNWLLFN 971

  Fly   452 WRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKS 516
            |...   |..||||:||||||:..|:.:...                                ..
  Rat   972 WYNM---RNCILADEMGLGKTIQSITFLYEI--------------------------------YL 1001

  Fly   517 KGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGN------------------NRE 563
            ||    ..|..||:.|.|.:..||.|..:..   :|.|.|:||:                  .|.
  Rat  1002 KG----IHGPFLVIAPLSTIPNWEREFRTWT---ELNVVVYHGSQASRRTIQLYEMYFKDPQGRV 1059

  Fly   564 TKGKYLRDYDIVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVV--RNHKSQSSLAVCDLRGKY 626
            .||.|  .:..::||::::..:...|.   .:.||.:::||||.:  ||.|....|.:.||  ::
  Rat  1060 IKGSY--KFHAIITTFEMILTDCPELR---NIPWRCVVIDEAHRLKNRNCKLLEGLKMMDL--EH 1117

  Fly   627 RWALTGTPIQNKELDVYALLKFLRCSPFDDLHTW-KKWIDNKSAGGQNRLNLLMKSLMLRRTKAQ 690
            :..|||||:||...::::||.||..|.|....|: :::.|.|:.....:|..::|.:||||.|..
  Rat  1118 KVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKED 1182

  Fly   691 LQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPT 755
            ::     .:|..||..:||:.|...:...|:.::                 |.:|.:.|...
  Rat  1183 VE-----KNLAPKEETIIEVELTNIQKKYYRAIL-----------------EKNFTFLSKGG--- 1222

  Fly   756 YNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGD- 819
             .|...||                        :|..::.||:.|.||.||    :|.|.:.:.:
  Rat  1223 -GQANVPN------------------------LLNTMMELRKCCNHPYLI----NGAEEKILEEF 1258

  Fly   820 ---HSSDSDTPEIDLLAQL---NKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKR 878
               |::||  |:..|.|.:   .||.:.|                 .|||.
  Rat  1259 KDAHNADS--PDFQLQAMIQAAGKLVLID-----------------KLLPK-------------- 1290

  Fly   879 SNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIP 943
                                     ||:...:.::.||....||||.|:|.:.......::|.:.
  Rat  1291 -------------------------LKAGGHRVLIFSQMVRCLDILEDYLIQRRYPYERIDGRVR 1330

  Fly   944 VKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQK 1008
            ...||..::.|:..::.:.|.||...|||:|:||..|:..::.|..||||.:.|||.|.:|:||.
  Rat  1331 GNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQS 1395

  Fly  1009 KNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVL----------TGAKVSSKLTIDDL--KGLFG 1060
            |:|.||:.:..::.|:.:......||.|...||          .|.:..||..|:||  ||.:|
  Rat  1396 KSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQSMSGRENATNGVQQLSKKEIEDLLRKGAYG 1459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	180/796 (23%)
		DEXHc_TTF2	439..686	CDD:350830	70/269 (26%)
Chd7	NP_001101376.2	Med15	<2..>318	CDD:312941
		Atrophin-1	194..>567	CDD:460830
		CD1_tandem_CHD5-9_like	785..849	CDD:349315	14/64 (22%)
		CD2_tandem_CHD5-9_like	868..925	CDD:349310	12/66 (18%)
		PLN03142	956..>1555	CDD:215601	164/698 (23%)
		BRK	2551..2592	CDD:462196
		BRK	2630..2674	CDD:197800