Protein Alignment lds and Chd6

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: XP_008760567.1
• Gene: Chd6 / 311607
• RGDID: 1310465
• Length: 2711
• Species: Rattus norvegicus
• Alignment Length: 1103
• Identity: 230/1103 - (20%)
• Similarity: 413/1103 - (37%)
• Gaps: 340/1103 - (30%)

  Fly    12 KEEDSV--------VNNSSLGRSRKS----SRLSKSSRLSKSSRPSSAGVVIDETQSEEEESQSS 64
            |::|.|        .:.:..|:.::|    ...:|..:.||...|:.   |..:.:.:.:...:.
  Rat   145 KQKDGVKKPRKPREASGTKEGKEKRSCTDCGPRTKPKKASKDQGPTP---VERKKKGKRKNETTV 206

  Fly    65 ETAESEKSDESDNSQNSQESEDSEDDSVRPSARNTKRKPLGIPSDSEDEEDELEQRALSPSTRMS 129
            |:.|.::|..:.:.|:.:|..:|.|...|.|.|..||:..         .::|:.:.:
  Rat   207 ESLELDQSLPNPSLQSPEEPSESADSQKRRSGRQVKRRKY---------NEDLDFKVV------- 255

  Fly   130 ITGVRPQDLSDDDSEIEYSDEVQEGPTEAPTAEAVVPRYTTQFAGNIQNDLHSTIGAADSEVLDD 194
                      |||.|.  ...:..|.|.|.:|                    ||:.....|..:|
  Rat   256 ----------DDDGET--IAVLGAGRTSALSA--------------------STLAWQAEEPPED 288

  Fly   195 SSGSDVLILSNKETPIEILSSTDDDATTNKENMSGPPFER-----PSKSLSPRSSAGASVVKTSK 254
            .:.....||::|              |..:.:...|||:.     ..::.|......|::.:..|
  Rat   289 DANIIEKILASK--------------TVQEVHPGEPPFDLELFYVKYRNFSYLHCKWATMEELEK 339

  Fly   255 NLSQPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRVQVSDAEKLFEKVAHK 319
            :   |.|...:|:..:..|..:......|:.:.:....  |:.::.|. ....||| ..|:|.|.
  Rat   340 D---PRIAQKIKRFRNKQAQMKHIFTEPDEDLFNPDYI--EIDRILEV-AHTKDAE-TGEEVTHY 397

  Fly   320 LPDKGSQIMKRIDTLRRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPSIDTLDWDELSEA 384
            |                     .:|.| |..::|...    ::..::|.:....::|      :.
  Rat   398 L---------------------VKWCS-LPYEESTWE----LEEDVDPAKVKEFESL------QI 430

  Fly   385 VNEIKPVYTGAQGMATFNNQKALTLESLKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAW 449
            :.|:|||    :..|:...||..|....|:.:                     .|..:|...:.|
  Rat   431 LPEVKPV----ERPASDAWQKLETSREYKNSN---------------------RLREYQLEGMNW 470

  Fly   450 M--SWRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVT 512
            :  :|..||   ..||||:||||||:..|:.         :||                  ..|.
  Rat   471 LLFNWYNRK---NCILADEMGLGKTIQSIAF---------LSE------------------IFVR 505

  Fly   513 GWKSKGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNN-------------RET 564
            |         ..|..|::.|.|.:..||.|..:..   ::...|:||:.             |:.
  Rat   506 G---------IHGPFLIIAPLSTITNWEREFRTWT---EMNAIVYHGSQISRQMIQQYEMVYRDA 558

  Fly   565 KGKYLR---DYDIVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVV--RNHKSQSSLAVCDLRG 624
            :|..|.   .:.:|:||::::..:...|..   :.|..:::||||.:  ||.|....|.:..|
  Rat   559 QGNPLSGVFKFHVVITTFEMILADCPELKK---IHWSCVVIDEAHRLKNRNCKLLEGLKLMAL-- 618

  Fly   625 KYRWALTGTPIQNKELDVYALLKFLRCSPF-DDLHTWKKWIDNKSAGGQNRLNLLMKSLMLRRTK 688
            :::..|||||:||...::::||.||..|.| .:....:::.|.|:.....:|..::|.:||||
  Rat   619 EHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETAFLEEFGDLKTEEQVKKLQSILKPMMLRR-- 681

  Fly   689 AQLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANK 753
              |:.|.:.|..|.:| .:||:.|...:...|:.::                 |.:|::.:..
  Rat   682 --LKDDVEKNLAPKQE-TIIEVELTNIQKKYYRAIL-----------------EKNFSFLTKG-- 724

  Fly   754 PTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMG 818
              .||...||                        ::..::.||:.|.||.||    :|.|.:.:.
  Rat   725 --ANQHNMPN------------------------LINTMMELRKCCNHPYLI----NGAEEKILE 759

  Fly   819 D----HSSDSDTPEIDLLAQ-LNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKR 878
            |    |||::...::..:.| ..||.:.|                 .|||.
  Rat   760 DFRKAHSSEASDFQLQAMIQAAGKLVLID-----------------KLLPK-------------- 793

  Fly   879 SNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIP 943
                                     |.:...|.::.||....||||.|:|.:.......::|.:.
  Rat   794 -------------------------LIAGGHKVLIFSQMVRCLDILEDYLIQRRYTYERIDGRVR 833

  Fly   944 VKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQK 1008
            ...||..::.|...::.:.|.||...|||:|:||..|:..::.|..||||.:.|||.|.:|:||.
  Rat   834 GNLRQAAIDRFCKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQS 898

  Fly  1009 KNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVL---------TGAKVSSKLTIDDL--KGLFG 1060
            |.|.:|:.:..::.|:.:......||.|...:|         .|.:..||:.::||  ||.:|
  Rat   899 KAVKVYRLITRNSYEREMFDKASLKLGLDKAILQDINRKGSTNGVQQLSKMEVEDLLRKGAYG 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	171/779 (22%)
		DEXHc_TTF2	439..686	CDD:350830	67/267 (25%)
Chd6	XP_008760567.1	PTZ00449	<100..372	CDD:185628	50/294 (17%)
		CD1_tandem_CHD5-9_like	287..352	CDD:349315	14/81 (17%)
		CD2_tandem_CHD5-9_like	371..429	CDD:349310	15/93 (16%)
		PLN03142	459..>984	CDD:215601	156/660 (24%)
		DEAD-like_helicase_N	460..681	CDD:475120	67/267 (25%)