Protein Alignment lds and HELLS

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_001275996.1
• Gene: HELLS / 3070
• HGNCID: 4861
• Length: 884
• Species: Homo sapiens
• Alignment Length: 941
• Identity: 206/941 - (21%)
• Similarity: 368/941 - (39%)
• Gaps: 289/941 - (30%)

  Fly   231 PFERPSKSLSPRSSAGASVVKTSKNLSQPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEE 295
            |.|||:.  |..|.|.|.|.:....:..|   |:|:::....|....|.:...:|  :::.:|.|
Human     2 PAERPAG--SGGSEAPAMVEQLDTAVITP---AMLEEEEQLEAAGLERERKMLEK--ARMSWDRE 59

  Fly   296 MRKLAEKRVQ-VSDAEKLFEK-VAHKLPDKGSQIMKRIDTLRRELAMDEQWISALRVQQ-SNVPA 357
            ..::..:|:| :.:...::.| :..|:..:..:..|:.:.|.|:.       .:|:|:: .|...
Human    60 STEIRYRRLQHLLEKSNIYSKFLLTKMEQQQLEEQKKKEKLERKK-------ESLKVKKGKNSID 117

  Fly   358 VRVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTGAQGMATFNNQKALTLESLKDLHVSLEDL 422
            ....||.:...|....::.:   :||.::: :.:.:.|:     .|:|....|:....::.:|||
Human   118 ASEEKPVMRKKRGREDESYN---ISEVMSK-EEILSVAK-----KNKKENEDENSSSTNLCVEDL 173

  Fly   423 PG--------PEVLAE----------DPV----GLKVSLMNHQKH----ALAW-----MSWRERK 456
            ..        .:.|:|          |||    |..|. ....||    .:.|     |.|....
Human   174 QKNKDSNSIIKDRLSETVRQNTKFFFDPVRKCNGQPVP-FQQPKHFTGGVMRWYQVEGMEWLRML 237

  Fly   457 LPRG--GILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGR 519
            ...|  |||||:||||||:..|:::...
Human   238 WENGINGILADEMGLGKTVQCIATIALM------------------------------------- 265

  Fly   520 KDTRRG--GTLVVC-PASLLRQWESEVESKVSRQKLTVCVHHGNNRE----------TKGKYLRD 571
              .:||  |..:|| |.|.|..|.:|.  |.....:...::||...|          .||. |:.
Human   266 --IQRGVPGPFLVCGPLSTLPNWMAEF--KRFTPDIPTMLYHGTQEERQKLVRNIYKRKGT-LQI 325

  Fly   572 YDIVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQ 636
            :.:|:|:::|..|:..:|...:   |:.:|:||.|.::|.|.:....:.......:..|||||:|
Human   326 HPVVITSFEIAMRDRNALQHCY---WKYLIVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTPLQ 387

  Fly   637 NKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAG-----------GQNRLNLL------------ 678
            |...::::||.||....||||.:::.|.|..|..           .||.|::|
Human   388 NNLSELWSLLNFLLPDVFDDLKSFESWFDITSLSETAEDIIAKEREQNVLHMLHQERIPRMYVSE 452

  Fly   679 -------------------------------------MKSLMLRRTKAQLQSDGKLNSLPNKELR 706
                                                 :...:|||    |:||..|...|.:|:
Human   453 FTDEGFFEGKLPSRKDLYDIRPYENTYLLKLHTNFEILTPFLLRR----LKSDVALEVPPKREV- 512

  Fly   707 LIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKP--------TYNQIKD-P 762
            ::...|.|::...|..::  :||:...|  ..:|:||  ...|...:|        .|::|.| |
Human   513 VVYAPLSKKQEIFYTAIV--NRTIANMF--GSSEKET--IELSPTGRPKRRTRKSINYSKIDDFP 571

  Fly   763 NGAYYKMHEKFARM----------------AGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDG 811
            |    ::.:..:::                ..|:..:|..:|::|   ||:.|.||.||:..:|.
Human   572 N----ELEKLISQIQPEVDRERAVVEVNIPVESEVNLKLQNIMML---LRKCCNHPYLIEYPIDP 629

  Fly   812 EESQTMGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLL 876
            ...:...|.         :|:....|..|.|.                 :||:
Human   630 VTQEFKIDE---------ELVTNSGKFLILDR-----------------MLPE------------ 656

  Fly   877 KRSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGT 941
                                       ||....|.::.||.||:||||.|:..........|:|:
Human   657 ---------------------------LKKRGHKVLLFSQMTSMLDILMDYCHLRDFNFSRLDGS 694

  Fly   942 IPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVG 1006
            :....|:..::.|| .:.:..:.|:|..|||:|:||..|:.:::.|..||||.:.|||||.:|:|
Human   695 MSYSEREKNMHSFN-TDPEVFIFLVSTRAGGLGINLTAADTVIIYDSDWNPQSDLQAQDRCHRIG 758

  Fly  1007 QKKNVIIYKFMCVDTVEQRI--KGLQDKKLD 1035
            |.|.|::|:.:..:|::|:|  :....:||:
Human   759 QTKPVVVYRLVTANTIDQKIVERAAAKRKLE 789

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	191/885 (22%)
		DEXHc_TTF2	439..686	CDD:350830	70/330 (21%)
HELLS	NP_001275996.1	DEXHc_HELLS_SMARCA6	220..499	CDD:350767	70/327 (21%)
		PLN03142	221..>869	CDD:215601	158/698 (23%)