Protein Alignment lds and Ercc6

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_001423629.1
• Gene: Ercc6 / 306274
• RGDID: 1311509
• Length: 1474
• Species: Rattus norvegicus
• Alignment Length: 1082
• Identity: 234/1082 - (21%)
• Similarity: 406/1082 - (37%)
• Gaps: 253/1082 - (23%)

  Fly    50 VIDETQSEEEESQSSETAESEKSDESDNSQNSQESEDSEDD------SVR----------PSA-- 96
            |.|:...||...|..::|..|.|..:..:...:|.:...||      |:|          |.|
  Rat    99 VYDQAVLEEGVLQQVDSAMHEASRVAQRADAEKEYQSVLDDLMSCTTSLRQINKIIEQLSPQAAS 163

  Fly    97 -RNTKRKPLGIPSDSEDEEDELEQRALSPSTRMSITGVRPQDLSDDDSEIEYSDEVQEGPTEAPT 160
             |:..||...:.....::|.:|::.........:|.|.....:..|...:| .::.:.||  :..
  Rat   164 NRDINRKLDSVKRQKYNKEQQLKKITAKQKRLQAILGGAEVHVELDHGSLE-EEDAEPGP--SCL 225

  Fly   161 AEAVVPRYTTQFAGNIQNDLHSTIGAADSE---------VLDDSSG-----SDVLILSNKETPIE 211
            ...::|...:.:...|:....:..|....:         :|:::||     :|...||.|.....
  Rat   226 GSMLMPAQESAWEELIRTGQMTPFGTPAPQKQEKKPRKIMLNEASGFEKYLADQAQLSFKRKKQA 290

  Fly   212 ILSSTDDDATTNKENMSGPPFERPSKSLSPRSSAGASVVKTSKNLSQPTIQ----AVLKQKTSPA 272
            ....|...|....|:..||...:|::.....|.....:.|..:.|.:..:|    ..|::...|.
  Rat   291 ANKRTAKKAVVVSESSRGPNETKPNQRSQALSQTDKRLKKHIRKLQRRALQFQGKVGLQRGKRPL 355

  Fly   273 APRR---SRIKSEDQKVVSQVVYDEEMRKLAEKRVQVSDAEKLFEKVAHKLPD--KGSQIMKRID 332
            .|..   :...:|.::..|.....||..:..|:.|.|..:    :.::::|..  ||.:..|::.
  Rat   356 EPEERPGAEGDTEGEESGSSPTDGEEEEEQEEEGVAVLSS----DDISYELKPLRKGQKYEKKVP 416

  Fly   333 TLRRELAMDEQWISALRVQQSNVP---AVRVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTG 394
            ...    :|:.:..:...:...|.   ..|.|.      |.|.    |.||         ..|
  Rat   417 VQE----IDDDFFPSSEEEDEAVEGRGGGRKVS------RRPD----DGDE---------DYY-- 456

  Fly   395 AQGMATFNNQKALTLESLKDLHVSLEDLPGPEVLAEDPVGLKV------SLMNHQKHALAWMSWR 453
            .|.:..:|..:....|.||     ||| ...|..||...|.||      .|..:|:..:.|: |.
  Rat   457 KQRLRRWNRLRLQDKEKLK-----LED-DSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRWL-WE 514

  Fly   454 ERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKG 518
            ......||||.|:||||||:.:|:.:......:..:.|                    :.::.:|
  Rat   515 LHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKIRTRG--------------------SNYRFEG 559

  Fly   519 RKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKYLRD----YDIVVTTY 579
                 .|.||:|||.:::.||..|..:.....::.:....|:....|.:.:||    :.:::|:|
  Rat   560 -----LGPTLIVCPTTVMHQWVKEFHTWWPPFRVAILHETGSCAHRKERLVRDIVHCHGVLITSY 619

  Fly   580 QIVAREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYA 644
            ..:......:|.   ..|..:||||.|.:||..:..:||....|..:|..|:|:|:||...::::
  Rat   620 SYIRLMQDDISR---HDWHYVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLRELWS 681

  Fly   645 LLKFLRCSPFDDLHTWKKWIDNK-SAGGQNR---------------LNLLMKSLMLRRTKAQLQS 693
            |..|........|..:.:..... :.||.:.               |...:...:|||.|    |
  Rat   682 LFDFTFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMK----S 742

  Fly   694 DGKLN-SLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYN 757
            |.|:: |||:|..:::...|..|:..|||..:
  Rat   743 DVKMSLSLPDKNEQVLFCRLTDEQHKVYQNFI--------------------------------- 774

  Fly   758 QIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSS 822
               |....|        |:...:.::.|.     |:.||:||.||.|..           |...:
  Rat   775 ---DSKAVY--------RILNGENQIFSG-----LVALRKICNHPDLFS-----------GGPKN 812

  Fly   823 DSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHR 887
            .|..||                            ||   |.:|.                |...:
  Rat   813 TSALPE----------------------------DG---LEEEQ----------------FGYWK 830

  Fly   888 PSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVN 952
            .|.|:.:|..:||  |......:.::.||...:|.||...|.....:.|.::||..:.:||.::.
  Rat   831 RSGKMIVVESLLK--IWHKQGQRVLLFSQSRQMLHILEVFLRAHKYSYLKMDGTTTIASRQPLIT 893

  Fly   953 EFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFM 1017
            ::|: :....|.||:...||:|:||.|||.:::.|..|||..:.||::|.:|:||||.|.:|:.:
  Rat   894 KYNE-DTSIFVFLLTTRVGGLGVNLTGANRVIIYDPDWNPSTDTQARERAWRIGQKKQVTVYRLL 957

  Fly  1018 CVDTVEQRIKGLQDKKLDLADGVLTGAKVSSKLTIDDLKGLF 1059
            ...|:|::|...|..|..|.:.||...|.......:||..||
  Rat   958 TAGTIEEKIYHRQIFKQFLTNRVLKDPKQRRFFKSNDLYELF 999

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	177/785 (23%)
		DEXHc_TTF2	439..686	CDD:350830	58/266 (22%)
Ercc6	NP_001423629.1	cc_ERCC-6_N	83..159	CDD:411064	13/59 (22%)
		HepA	316..981	CDD:440319	185/842 (22%)
		CSB_WHD	1402..1473	CDD:439329