Protein Alignment lds and Hells

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_001099841.1
• Gene: Hells / 294071
• RGDID: 1309820
• Length: 837
• Species: Rattus norvegicus
• Alignment Length: 892
• Identity: 199/892 - (22%)
• Similarity: 348/892 - (39%)
• Gaps: 238/892 - (26%)

  Fly   231 PFERPSKSLSPRSSAGASVVKTSKNLSQPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEE 295
            |.|||:.|..|                   :...:.::|.||....:.::.|:|.....:..:.:
  Rat     2 PAERPASSSGP-------------------LAPEMAEQTEPAVITPAMLEEEEQLEAEGLEKERK 47

  Fly   296 MRKLAEKRVQVSDAEKLFEKVAHKLPDKGSQIMKRIDTLRRELAMDEQWISALRVQQSNVPAVRV 360
            |.:.|.|.......|..:.::.|.| :|.:...|.:.|     .|::|.:...:.::......|.
  Rat    48 MLEEARKSWDRESTEIRYRRLQHLL-EKSNIYSKFLLT-----KMEQQQLEEQKKKEKLEKKKRS 106

  Fly   361 VKPT--------------LNPPRAPSIDTLDWDEL---SEAVNEIKPVYTGAQGMATFNNQKALT 408
            :|.|              :...|....::.:..|:   .|.::..|.........::..|.....
  Rat   107 LKVTEGKNLIDGNEENTVMKKKRGREDESYNISEVMSKEEILSVAKKHKDNEDENSSTTNLCVED 171

  Fly   409 LESLKDLHVSLEDLPGPEVLAE-----DPV----GLKVSLMNHQKH----ALAW-----MSWRER 455
            |:..||.:..::|.....|...     |||    |..|. ....||    .:.|     |.|...
  Rat   172 LQKNKDSNSMIKDRLSQTVRQNSKFFFDPVRKCNGQPVP-FQQPKHFTGGVMRWYQVEGMEWLRM 235

  Fly   456 KLPRG--GILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKG 518
            ....|  |||||:||||||:..|:::...
  Rat   236 LWENGINGILADEMGLGKTVQCIATIALM------------------------------------ 264

  Fly   519 RKDTRRG--GTLVVC-PASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKYLRD--------- 571
               .:||  |..:|| |.|.|..|.:|.  |....::...::|||.:|.: |.:::
  Rat   265 ---IQRGVPGPFLVCGPLSTLPNWMAEF--KRFTPEIPTLLYHGNRQERR-KLVKNIHKRQGTLQ 323

  Fly   572 -YDIVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPI 635
             :.:|:|:::|..|:..:|...:   |:.:|:||.|.::|.|.:....:.......:..|||||:
  Rat   324 IHPVVITSFEIAMRDQNALQHCY---WKYLIVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTPL 385

  Fly   636 QNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAG-----------GQNRLNLLMKSL---MLRR 686
            ||...::::||.||....||||.:::.|.|..|..           .||.|::|.:.|   :|||
  Rat   386 QNNLSELWSLLNFLLPDVFDDLKSFESWFDITSLSETAEDIIAKEREQNVLHMLHQILTPFLLRR 450

  Fly   687 TKAQLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDA 751
                |:||..|...|.:|:.:.....:|:|  ::.|.:. :||:...|  ...|:||  ...|..
  Rat   451 ----LKSDVALEVPPKREVVVYAPLCNKQE--IFYTAIV-NRTIANMF--GSCEKET--VELSPT 504

  Fly   752 NKPTYNQIKDPNGAYYKMHEKFAR-----MAGSKKEVKSHDILV----------------LLLRL 795
            .:|.....|..|   |...::|..     ::..:.|||....:|                :::.|
  Rat   505 GRPKRRSRKSIN---YSELDQFPSELEKLISQIQPEVKRERTVVEGNIPIESEVNLKLQNIMMLL 566

  Fly   796 RQICCHPGLIDAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPP 860
            |:.|.||.:|:..:|....:...|.         :|:....|..|.|.
  Rat   567 RKCCNHPYMIEYPIDPVTQEFKIDE---------ELVTNSGKFLILDR----------------- 605

  Fly   861 LLPDEARIAKASKNLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILR 925
            :||:                                       ||....|.:|.||.||:||||.
  Rat   606 MLPE---------------------------------------LKKRCHKVLVFSQMTSMLDILM 631

  Fly   926 DHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHW 990
            |:..........|:|::....|:..:..|| .:.:..:.|:|..|||:|:||..|:.:::.|..|
  Rat   632 DYCHLRNFTFSRLDGSMSYSEREKNIYSFN-TDPEVFLFLVSTRAGGLGINLTAADTVIIYDSDW 695

  Fly   991 NPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRI--KGLQDKKLD 1035
            |||.:.|||||.:|:||.|.|::|:.:..:|::|:|  :....:||:
  Rat   696 NPQSDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIVERAAAKRKLE 742

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	188/836 (22%)
		DEXHc_TTF2	439..686	CDD:350830	70/284 (25%)
Hells	NP_001099841.1	DEXHc_HELLS_SMARCA6	219..452	CDD:350767	70/281 (25%)
		PLN03142	220..>797	CDD:215601	157/648 (24%)