Protein Alignment lds and rrp2

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_596602.1
• Gene: rrp2 / 2540464
• PomBaseID: SPBC23E6.02
• Length: 1040
• Species: Schizosaccharomyces pombe
• Alignment Length: 1145
• Identity: 295/1145 - (25%)
• Similarity: 462/1145 - (40%)
• Gaps: 285/1145 - (24%)

  Fly    64 SETAESEKSDESD----NSQNSQESEDSEDDSVRPSARNTKRKPL--GIPSDSEDEEDELEQ--- 119
            :.|.:...|..||    |..|..|.|       |..|...:::.|  ....||....:.:|.
pombe    31 NNTPDYSSSASSDQLLKNDINRHEME-------RRIAFLNRKQALFNAFMHDSSSSLNTMESNIE 88

  Fly   120 --RALSPSTRMSITGVRPQD------LSDDDSEIEYSDEVQEGP---TEAPTAEAVVPRYTTQFA 173
              ..|.|:.. |:..::|.:      ||.::::..|:|.....|   .:.|...|:    |....
pombe    89 KVNGLFPNDN-SVIALKPNEEKLNSSLSVENNDSTYTDATLIAPKIGLDRPNINAI----TIDVD 148

  Fly   174 G-NIQNDLHST---IGAADSEVLDDSSGSDVLILSNKETPIEILSSTDDDATTNKENMSGPPFER 234
            | ::||::.|:   :..:.|:.|.:.....  :..|....|.:..|..||...           |
pombe   149 GHSLQNEISSSTDKLSPSQSDALFEQKQDS--LFWNDNAVIVVSDSESDDNNV-----------R 200

  Fly   235 PSKSLSPRSSAGASVVKTSKNLSQPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKL 299
            ...||:......   :|..:||....:.:..|:...|:.|            |...........|
pombe   201 TKSSLNDHDKVN---MKEKRNLELAFMNSKRKKLELPSLP------------VLSTAGPSYTNSL 250

  Fly   300 AEKRVQVSDAEKLFEKVAHKLPDKGSQIMKRIDTLRRELAMDEQWISALRVQQSNVPAVRVVKP- 363
            |.......:..|:| ...|.|.|  .:.::...|....:::.::..:.:..|.....:..|:.|
pombe   251 ALPPFHHHNNYKMF-NTTHTLED--DKFLQGKGTSNNPISLSDEEDNEINFQNKRYGSDSVILPG 312

  Fly   364 -TLNPPRAPS----IDTLDW--DELS--EAVNEIKPVYTGAQGMATFNNQKA-----LTLESL-K 413
             .|:..:.|.    :..|.|  |...  |..|           ::..||||.     ..||.| |
pombe   313 GLLHDSKLPEPGKHLFHLQWYHDRFHNIEGFN-----------LSDSNNQKVQDDQQQQLEELFK 366

  Fly   414 DLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAWMSWRERKLPRGGILADDMGLGKTLTMISS 478
            ||...|  :..|.:....|.||..:||.|||..|.|:...|....:|||||||||||||:..::.
pombe   367 DLDEQL--VNDPTIREGTPAGLIPTLMEHQKEGLMWLKRLEESSKKGGILADDMGLGKTVQALAL 429

  Fly   479 VLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWESEV 543
            ::.                      :..:.|||.             .||::.|.|||:||.:|:
pombe   430 LVT----------------------RPPESKSVK-------------TTLIITPVSLLQQWHNEI 459

  Fly   544 ESKVS-RQKLTVCVHHGNNRETK-GKYLRDYDIVVTTYQIVAREHKSLSA--------------- 591
            .:|:: ..:.||.:|||::::.| .:.|..||||:|||.::|.|.|:..|
pombe   460 LTKIAPSHRPTVYIHHGSSKKHKIAEQLMSYDIVLTTYNVIAYEFKNKMAYDKSIEDNAPIKKFE 524

  Fly   592 ---VFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSP 653
               .|..:|.|:|||||..::|..:.::...|.|...|||.|:|||:||...:.|:|:||||..|
pombe   525 HLPFFEAEWYRVILDEAQTIKNRNTLAARGCCLLESTYRWCLSGTPMQNGVEEFYSLIKFLRIKP 589

  Fly   654 FDDLHTWKKWID-------NKSAGGQNRLNLLMKSLMLRRTKAQLQSDGK-LNSLPNKELRLIEI 710
            :.|..::.|...       |.|| ...|...|:|:::||||| ..:.||| :.:||.|.....|.
pombe   590 YSDWSSFSKDFTIPLSSNINTSA-PMKRFRGLLKAVLLRRTK-NTKIDGKPILTLPPKTAVKSET 652

  Fly   711 SLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFAR 775
            .|...||..|.|:.:.::....::|.:..
pombe   653 DLSSSEMEFYNTLQSGAQIQMRKYLQEGT------------------------------------ 681

  Fly   776 MAGSKKEVKSH--DILVLLLRLRQICCHPGLI---DAMLDGEES-QTMGDHSSDSDTPE------ 828
                   :.:|  .:|||||||||.||||.||   :|.:|..:| |.......:...||
pombe   682 -------ITTHYGSLLVLLLRLRQACCHPWLIVAREAAVDDNDSFQAKNRAIYNQIYPEAVNRLK 739

  Fly   829 ----------IDLLAQLNKL--------------AITDTSTDGQQ----------SVANAGDDGP 859
                      :|::|:|..:              .||.:....:|          ||.....|..
pombe   740 LIETLQCSLCMDVVAELLIIVPCGHFLCRECLTHVITSSEDMAKQTSNENISPKCSVCEEYIDTE 804

  Fly   860 PLL-----------------PDEARIAKASKNLLKR-SNPVFNLH------------RPSSKINM 894
            .||                 .::.|....|:.|.|: ||.:.|..            ..|:||..
pombe   805 RLLSYALFRRYSGMAPIVDADNKLRTENISELLPKQYSNILENRQMGMKIFTDPKHWTTSTKIEK 869

  Fly   895 VIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNR-QDIVNEFNDRN 958
            .:..:|..|.|...||.::.||:.|.|::......::|:..|...|.:....| |.::|...|.|
pombe   870 ALNAVKEIIKKQPTDKILIFSQFVSFLELFTVPFRQEGIKYLMYTGGLSTAERNQALINFEVDPN 934

  Fly   959 NQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVE 1023
              .||||:||.||.|||||..|||:::||..|||.:|.||.||.:|:||.|.|.|.:.:..:|:|
pombe   935 --VRVLLISLKAGNVGLNLTCANHVIILDPFWNPYIEEQAVDRAHRIGQDKPVNILRIVTNNTIE 997

  Fly  1024 QRIKGLQDKKLDLADGVL--TGAKVSSKLTIDDLKGLFGM 1061
            :|:..|||:|.:|.|..|  .|.:..|:|...:|..||||
pombe   998 ERVLALQDRKRELIDSALGEKGLREISRLNTKELSFLFGM 1037

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	240/874 (27%)
		DEXHc_TTF2	439..686	CDD:350830	88/273 (32%)
rrp2	NP_596602.1	HepA	<380..1016	CDD:440319	209/717 (29%)
		RING_Ubox	742..812	CDD:473075	11/69 (16%)