Protein Alignment lds and Ercc6l

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_666347.2
• Gene: Ercc6l / 236930
• MGIID: 2654144
• Length: 1240
• Species: Mus musculus
• Alignment Length: 797
• Identity: 182/797 - (22%)
• Similarity: 311/797 - (39%)
• Gaps: 227/797 - (28%)

  Fly   323 KGSQIMKRIDTLRRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPSIDTLDWDELSEAVNE 387
            :.||.:..::||..:||.     |.||..|....|.:               ..|.:|..:..|.
Mouse     2 EASQGLAEVETLSPQLAE-----SYLRYVQEAKEAAK---------------NGDLEESLKLFNL 46

  Fly   388 IKPVYTGAQGMATFNNQKALTLESLKDLHVSLEDLPGPEVLAEDPVGLKV-------------SL 439
            .|.:         |..:|.::  .::.|..:||.|...|   :|...:.|             .|
Mouse    47 AKDI---------FPTKKVMS--RIQKLQEALEQLAEEE---DDDEFIDVCSSGLLLYRELYEKL 97

  Fly   440 MNHQKHALAWMSWRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDK 504
            ..|||..:|::....:...:|||||||||||||:.:|:.:....:...::.
Mouse    98 FEHQKEGIAFLYSLYKDGRKGGILADDMGLGKTVQIIAFLSGMFDASLVNH-------------- 148

  Fly   505 NKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKYL 569
                                  .|::.|.:|:..|.:|........:  |...||:::..:.:.|
Mouse   149 ----------------------VLLIMPTNLINTWVNEFAKWTPGMR--VKTFHGSSKSERTRSL 189

  Fly   570 ----RDYDIVVTTYQIVAREHKSLSAVFG--VKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRW 628
                :...:|:||||::....:.|::..|  ..|..:||||||.:::..::|::....:....|.
Mouse   190 TRIQQRNGVVITTYQMLLNNWQQLASFNGQAFVWDYVILDEAHKIKSASTKSAVCARAIPASNRL 254

  Fly   629 ALTGTPIQNKELDVYALLKFLRC--SPFDDLHTWK--------KWIDNKSAGGQNRLNL------ 677
            .|||||:||...::::|..| .|  |....|.|:|        :..:..:..|:..|.|
Mouse   255 LLTGTPVQNNLQELWSLFDF-ACQGSLLGTLKTFKMEYEHPIIRAREKDATPGEKALGLKISENL 318

  Fly   678 --LMKSLMLRRTKAQLQSDGKLNSLPNKELRLIE-----------ISL-DKEEMNVYQTVMTYSR 728
              ::|...|||||.::|:    ....|.|.||.|           .|| .|.::.|:..::....
Mouse   319 MEIIKPYFLRRTKEEVQT----KKADNPEARLGEKNPAGEAICDMFSLARKNDLIVWIRLLPLQE 379

  Fly   729 TLFAQFLHQRAERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLL 793
            .::.:|:            ..|..|....:.:.|                          |..|.
Mouse   380 EIYRKFV------------SLDHIKELLMETRSP--------------------------LAELG 406

  Fly   794 RLRQICCHPGLIDAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDG 858
            .|:::|.||.|:.|                    ....|..|.....:....:.|:.|:|.  :.
Mouse   407 VLKKLCDHPRLLSA--------------------RACRLLNLGTATFSAQDENEQEDVSNM--NS 449

  Fly   859 PPLLPDEARIAKASK-----NLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWT 918
            ...|||:..|.::.|     :||:|                         |:....:.:|.||..
Mouse   450 IDHLPDKTLIQESGKMIFLMSLLER-------------------------LQDEGHQTLVFSQSI 489

  Fly   919 SVLDILRDHLSKDGVATLSLNGTIP-VKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANH 982
            .:|:|:...|......||.::||:. :..|:..:..| .:|.:..|.||:...|||||.|..|..
Mouse   490 KILNIIERLLKNKHFKTLRIDGTVTHLWEREKRIQLF-QQNKEYSVFLLTTQVGGVGLTLTAATR 553

  Fly   983 LLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVL---TGA 1044
            :::.|..|||..:|||.||:||:|||:||::|:.:...|||::|...|..|    |.::   ||.
Mouse   554 VVIFDPSWNPATDAQAVDRVYRIGQKENVVVYRLITCGTVEEKIYRRQVFK----DSLIRQTTGE 614

  Fly  1045 KVS--SKLTIDDLKGLF 1059
            |.:  ...|..:||.||
Mouse   615 KKNPFRYFTKQELKELF 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	174/772 (23%)
		DEXHc_TTF2	439..686	CDD:350830	63/270 (23%)
Ercc6l	NP_666347.2	TPR 1	21..54		9/56 (16%)
		HepA	<96..613	CDD:440319	150/649 (23%)
		DEXHc_ERCC6L	97..329	CDD:350759	63/270 (23%)
		DEAH box	229..232		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	736..760
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	778..813
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	845..879
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	974..1085
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1104..1185
		TPR 2	1191..1224