Protein Alignment lds and ERCC6

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_000115.1
• Gene: ERCC6 / 2074
• HGNCID: 3438
• Length: 1493
• Species: Homo sapiens
• Alignment Length: 1165
• Identity: 235/1165 - (20%)
• Similarity: 429/1165 - (36%)
• Gaps: 308/1165 - (26%)

  Fly     4 ENSEYYSDKEEDSVVNNSSLGRSRKSSR-----LSKSSRLSKSSRPSSAGV--------VIDETQ 55
            |..||.|.:.....::.|::|.:..:.|     |.......::..||:..:        |.|:..
Human    40 EVEEYLSFRSVGDGLSTSAVGCASAAPRRGPALLHIDRHQIQAVEPSAQALELQGLGVDVYDQDV 104

  Fly    56 SEE-----------EESQSSETAESEKS-----DESDNSQNSQESEDSEDDSVRPSA---RNTKR 101
            .|:           |.|::|:..:.||.     |:..:...|....:...:.:.|.|   |:..|
Human   105 LEQGVLQQVDNAIHEASRASQLVDVEKEYRSVLDDLTSCTTSLRQINKIIEQLSPQAATSRDINR 169

  Fly   102 KPLGIPSDSEDEEDELEQRALSPSTRMSITGVRPQDLSDDDSEIEYSDEVQEGPTEAPTAEAVVP 166
            |...:.....::|.:|::.........:|.|.....:..|.:.:|  ::.:.||:.  ....::|
Human   170 KLDSVKRQKYNKEQQLKKITAKQKHLQAILGGAEVKIELDHASLE--EDAEPGPSS--LGSMLMP 230

  Fly   167 RYTTQFAGNIQNDLHSTIGAADSE---------VLDDSSGSDVLILSNKETPIEILSSTDDDATT 222
            ...|.:...|:....:..|....:         :|:::||.:..:.              |.|..
Human   231 VQETAWEELIRTGQMTPFGTQIPQKQEKKPRKIMLNEASGFEKYLA--------------DQAKL 281

  Fly   223 NKENMSGPPFERPSKSLSPRSSAGASVVKTS----KNLSQPTIQA-VLKQKTSPAAPRRSRIKSE 282
            :        |||..:..:.|::..|....|.    :|.::|..:| ||.:|       ..|:|..
Human   282 S--------FERKKQGCNKRAARKAPAPVTPPAPVQNKNKPNKKARVLSKK-------EERLKKH 331

  Fly   283 DQKVVSQVV--------------YDEEMRKLAEKRVQVSDAEKLFEKVAHKLPDKGSQIMKRIDT 333
            .:|:..:.:              ::.:||..||...:..::|....:...:..|      ..::.
Human   332 IKKLQKRALQFQGKVGLPKARRPWESDMRPEAEGDSEGEESEYFPTEEEEEEED------DEVEG 390

  Fly   334 LRRELAMD--EQWISAL---RVQQSNVPAVRVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYT 393
            ...:|:.|  :..:..|   ..:|..||                :..:|.|....:..|.:....
Human   391 AEADLSGDGTDYELKPLPKGGKRQKKVP----------------VQEIDDDFFPSSGEEAEAASV 439

  Fly   394 GA-------------QGMATFNNQKALTLESL----KDLHVSLEDLPGPEVLAEDPVGLKV---- 437
            |.             .|...:..|:......|    |:..:.||| ...|..||...|.||
Human   440 GEGGGGGRKVGRYRDDGDEDYYKQRLRRWNKLRLQDKEKRLKLED-DSEESDAEFDEGFKVPGFL 503

  Fly   438 --SLMNHQKHALAWMSWRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDS 500
              .|..:|:..:.|: |.......||||.|:||||||:.:|:.:......:..:.|
Human   504 FKKLFKYQQTGVRWL-WELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKIRTRG--------- 558

  Fly   501 EDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETK 565
                       :.::.:|     .|.|::|||.:::.||..|..:.....::.:....|:....|
Human   559 -----------SNYRFEG-----LGPTVIVCPTTVMHQWVKEFHTWWPPFRVAILHETGSYTHKK 607

  Fly   566 GKYLRD----YDIVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKY 626
            .|.:||    :.|::|:|..:......:|.   ..|..:||||.|.:||..:..:||....|..:
Human   608 EKLIRDVAHCHGILITSYSYIRLMQDDISR---YDWHYVILDEGHKIRNPNAAVTLACKQFRTPH 669

  Fly   627 RWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNK-SAGGQNR---------------L 675
            |..|:|:|:||...::::|..|:.......|..:.:..... :.||.:.               |
Human   670 RIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVL 734

  Fly   676 NLLMKSLMLRRTKAQLQSDGKLN-SLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRA 739
            ...:...:|||.|    ||.|:: |||:|..:::...|..|:..|||..:.
Human   735 RDTINPYLLRRMK----SDVKMSLSLPDKNEQVLFCRLTDEQHKVYQNFVD-------------- 781

  Fly   740 ERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGL 804
                        :|..|                  |:...:.::.|.     |:.||:||.||
Human   782 ------------SKEVY------------------RILNGEMQIFSG-----LIALRKICNHP-- 809

  Fly   805 IDAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIA 869
                                                 |..:.|.:::....||  .|..|:
Human   810 -------------------------------------DLFSGGPKNLKGLPDD--ELEEDQ---- 831

  Fly   870 KASKNLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVA 934
                         |...:.|.|:.:|..:||  |......:.::.||...:||||...|......
Human   832 -------------FGYWKRSGKMIVVESLLK--IWHKQGQRVLLFSQSRQMLDILEVFLRAQKYT 881

  Fly   935 TLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQ 999
            .|.::||..:.:||.::..:|: :....|.||:...||:|:||.|||.:::.|..|||..:.||:
Human   882 YLKMDGTTTIASRQPLITRYNE-DTSIFVFLLTTRVGGLGVNLTGANRVVIYDPDWNPSTDTQAR 945

  Fly  1000 DRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVLTGAKVSSKLTIDDLKGLF 1059
            :|.:|:||||.|.:|:.:...|:|::|...|..|..|.:.||...|.......:||..||
Human   946 ERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQRRFFKSNDLYELF 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	171/816 (21%)
		DEXHc_TTF2	439..686	CDD:350830	59/266 (22%)
ERCC6	NP_000115.1	N-terminal domain, essential for its chromatin remodeling activity. /evidence=ECO:0000269|PubMed:29203878	1..510		87/525 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39
		cc_ERCC-6_N	83..159	CDD:411064	12/75 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..323		8/35 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	344..453		16/130 (12%)
		HepA	391..987	CDD:440319	165/755 (22%)
		DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	646..649		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1042..1147
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1181..1247
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1318..1384
		CSA-interacting motif (CIM). /evidence=ECO:0000269|PubMed:32355176	1386..1398
		Ubiquitin-binding domain (UBD). /evidence=ECO:0000269|PubMed:20541997	1400..1428
		CSB_WHD	1420..1492	CDD:439329
		Winged-helix domain (WHD). /evidence=ECO:0000305|PubMed:29203878	1429..1493
		Essential for its interaction with RNA polymerase II, transcription-coupled nucleotide excision repair activity, association with chromatin after UV irradiation and for mediating the UV-induced translocation of ERRC8 to the nuclear matrix. /evidence=ECO:0000269|PubMed:26620705	1446..1493