DRSC/TRiP Functional Genomics Resources

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Protein Alignment lds and Hltf

DIOPT Version :10

Sequence 1:NP_524850.2 Gene:lds / 45894 FlyBaseID:FBgn0002542 Length:1061 Species:Drosophila melanogaster
Sequence 2:NP_033236.2 Gene:Hltf / 20585 MGIID:1196437 Length:1003 Species:Mus musculus


Alignment Length:881 Identity:242/881 - (27%)
Similarity:350/881 - (39%) Gaps:288/881 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   389 KPVYTGAQGMATFNNQKALTLESLK-DLHVSLEDLPGPE--VLAEDPVGLKVSLMNHQKHALAWM 450
            :|.:...|          :|.:.|| :.....|||...:  |..|....::..|:.|||.|||||
Mouse   197 RPAHVAVQ----------MTTDQLKTEFDKLFEDLKEDDRTVEMEPAEAIETPLLPHQKQALAWM 251

  Fly   451 SWRE--RKLP--------------------------RGGILADDMGLGKTLTMISSVLA------ 481
            ..||  ::||                          .|||||||||||||||.|:.:|.      
Mouse   252 IARENSKELPPFWEQRNDLYYNTITNFSVKERPENVHGGILADDMGLGKTLTAIAVILTNFDDGR 316

  Fly   482 ---CKNGQEMSEGK--------------DESSDSDSEDDKNKKRKSVTG---------------- 513
               .|.|::...||              |:..|..||.....:..|::|                
Mouse   317 PLLSKRGKKNHPGKEYKDETIKRRGSNMDKKEDGHSESSTCGEEPSISGTPEKSSCTLSQLSSVC 381

  Fly   514 -------------------------WKSKG----------------------------------- 518
                                     .|.||                                   
Mouse   382 PKRRKISVQYIESSDSEEIETSELPQKMKGKLKNVQLNTKSRVKGSSKVKEDSKFALTFFASATQ 446

  Fly   519 RKDTRRG-----------------GTLVVCPASLLRQWESEVESKV-SRQKLTVCVHHGNNRETK 565
            ||..::|                 .||::||.|:|..|..:....| |...|...|::|.:|...
Mouse   447 RKMLKKGMSMMECSEACDTGERTRATLIICPLSVLSNWIDQFGQHVKSEVHLNFYVYYGPDRIRD 511

  Fly   566 GKYLRDYDIVVTTYQIVAREH--KSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRW 628
            ..:|...||::|||.|:..::  |..|.:..:||.|:||||.|.:||..:|.:.||.:|..:.||
Mouse   512 SAWLSKQDIILTTYNILTHDYGTKDDSPLHSIKWLRVILDEGHAIRNPNAQQTKAVLELEAERRW 576

  Fly   629 ALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNK----SAGGQNRLNLLMKSLMLRRTKA 689
            .||||||||...|:::||.||:..||.|...|.:.|...    ..||..||..|:|::.|||||.
Mouse   577 VLTGTPIQNSLKDLWSLLSFLKLKPFIDREWWYRIIQRPVTTGDEGGLRRLQSLIKNITLRRTKT 641

  Fly   690 QLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKP 754
            .......:..||.:::.:..|:|.:||..:||:|.                              
Mouse   642 SKIKGKPVLELPERKVFIQHITLSEEERKIYQSVK------------------------------ 676

  Fly   755 TYNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGD 819
              |:.|...|.|:......|..|         |:|.|||||||||||..|:          |.|.
Mouse   677 --NEGKAAIGRYFTEGTVLAHYA---------DVLGLLLRLRQICCHTHLL----------TNGM 720

  Fly   820 HSSD---SDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGP----------PLLPDEARI--- 868
            .||.   |||||     :|.|:.|     :..:.:.::|.|..          |::...|.:   
Mouse   721 SSSGPSRSDTPE-----ELRKMLI-----EKMKIILSSGSDEECAICLDSLTFPVITHCAHVFCK 775

  Fly   869 -------------AKA--------SKNLL------------KRSNPVFNLHRPSSKINMVIQILK 900
                         ||.        ..|||            |.|:..:   :.|||||.::..|.
Mouse   776 PCICQVIHSEQPHAKCPLCRNEIHGDNLLECPPEELACDSDKESSMEW---KSSSKINALMHALI 837

  Fly   901 TSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEF-NDRNNQKRVL 964
            ....|..:.|::||||:|:.|.::...|...|.....|:|::..|.|.:.:..| |.......::
Mouse   838 ELRTKDPNIKSLVVSQFTTFLSLIETPLKASGFVFTRLDGSMAQKKRVESIQRFQNTEAGSPTIM 902

  Fly   965 LLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGL 1029
            ||||.||||||||..|:.:.|:|..|||..|.|..||.:|:|||:.|||.||:..|:||:.:..:
Mouse   903 LLSLKAGGVGLNLCAASRVFLMDPAWNPAAEDQCFDRCHRLGQKQEVIITKFIVKDSVEENMLKI 967

  Fly  1030 QDKKLDLADGV----------LTGAKVSSKLTIDDL 1055
            |:.|.|||.|.          :..||::...|:.||
Mouse   968 QNTKRDLAAGAFGTKKTDANDMKQAKINEIRTLIDL 1003

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ldsNP_524850.2 HepA 287..1041 CDD:440319 237/865 (27%)
DEXHc_TTF2 439..686 CDD:350830 109/397 (27%)
HltfNP_033236.2 DNA-binding. /evidence=ECO:0000250 38..287 23/99 (23%)
HIRAN 60..153 CDD:400928
DEXHc_HLTF1_SMARC3 240..638 CDD:350829 109/397 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 317..373 10/55 (18%)
HepA <468..980 CDD:440319 181/575 (31%)
DEGH box 551..554 2/2 (100%)
RING-HC_HLTF 749..803 CDD:438172 6/53 (11%)
Interaction with SP1 and SP3. /evidence=ECO:0000250 919..1003 30/83 (36%)
Blue background indicates that the domain is not in the aligned region.

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