Protein Alignment lds and chd-3

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_510140.1
• Gene: chd-3 / 181421
• WormBaseID: WBGene00000482
• Length: 1787
• Species: Caenorhabditis elegans
• Alignment Length: 1148
• Identity: 234/1148 - (20%)
• Similarity: 421/1148 - (36%)
• Gaps: 331/1148 - (28%)

  Fly     4 ENSEYYSDKEEDSVVNNSSLGRSRKSSRLSKSSRLSKSSRPSSAGVVIDETQSEEEESQSSETAE 68
            |...:.||:|.::::       .:...:..::.:..:.:|.:.|...:|:.::..|.:::|:.|.
 Worm   197 EGGGHDSDQEFEALI-------KQHEKQQDEAEKGKEEARINRAAAKVDKRKAALESARASKRAR 254

  Fly    69 SEKSDESDNSQNSQE--SEDSE----DDSVRP-----SARNTKRKPLG---IPSDSEDEEDEL-- 117
            .|:....:|.|.:.|  ::|.|    |...|.     ...|.::.|.|   .|...|...|.|
 Worm   255 KEQGVVEENHQENCEVCNQDGELMLCDTCTRAYHVACIDENMEQPPEGDWSCPHCEEHGPDVLIV 319

  Fly   118 -EQRALSPSTRMSITGVRPQDLSDDDSEIEYSDEVQEGP-TEAPTAEAVVPRYTTQFAGNIQNDL 180
             |:.|.:......|.......|..|.....|.....:.| ||.|..|...||.
 Worm   320 EEEPAKANMDYCRICKETSNILLCDTCPSSYHAYCIDPPLTEIPEGEWSCPRC------------ 372

  Fly   181 HSTIGAADSEVLDDSSGSDVLILS------NKETPIEILSSTDDDATTNKENMSGPPFERPSKSL 239
                      ::.:.:.....|||      :...|:|.....:    .:|:::    |.:|.:.:
 Worm   373 ----------IIPEPAQRIEKILSWRWKEISYPEPLECKEGEE----ASKDDV----FLKPPRKM 419

  Fly   240 SPRSSAGASVVK-----------TSKNLSQPTIQAVLKQKTSPAAPRRSRIKSE-----DQKVVS 288
            .||... ...||           .|:.|......|:::...       .::.||     ::..:|
 Worm   420 EPRRER-EFFVKWKYLAYWQCEWLSETLMDVYFTALVRMYW-------RKVDSENPPIFEESTLS 476

  Fly   289 QVVYDEEMRKLAEKRVQ--VSDAEKLFEKVAHKLPDKGSQ---------------IMKRIDT--L 334
            :...|.:..||.|:..|  |........::.:.|....||               ..:|.||  .
 Worm   477 RHHSDHDPYKLRERFYQYGVKPEWMQIHRIINHLSYAKSQQDYLVKWKELSYEHATWERDDTDIA 541

  Fly   335 RRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTGAQGM- 398
            ..|.|:.:.|....|:....||  |.|:..:...|.                        |:|:
 Worm   542 NYEDAIIKYWHHRERMLNDEVP--RNVQKMIAKQRE------------------------AKGLG 580

  Fly   399 -----ATFNNQKALTLESLKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAWMSWRERKLP 458
                 .|...:|...::.||...|.      |:.::|....|       ..:.|..::|......
 Worm   581 PKEDEVTSRRKKREKIDILKKYEVQ------PDFISETGGNL-------HPYQLEGINWLRHCWS 632

  Fly   459 RG--GILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKD 521
            .|  .||||:||||||:..::.:...     |.||.
 Worm   633 NGTDAILADEMGLGKTVQSLTFLYTL-----MKEGH----------------------------- 663

  Fly   522 TRRGGTLVVCPASLLRQWESEVESKV----------SRQKLTVCVHH----------GNNRETKG 566
             .:|..|:..|.|.:..||.|.|...          .|:...|...|          |..:.:|.
 Worm   664 -TKGPFLIAAPLSTIINWEREAELWCPDFYVVTYVGDRESRMVIREHEFSFVDGAVRGGPKVSKI 727

  Fly   567 KYLRD--YDIVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWA 629
            |.|.:  :.:::|:|:.:..:...||:   :.|..:::||||.::|::|.....:.:...:||..
 Worm   728 KTLENLKFHVLLTSYECINMDKAILSS---IDWAALVVDEAHRLKNNQSTFFKNLREYNIQYRVL 789

  Fly   630 LTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAGGQ-NRLNLLMKSLMLRRTKAQLQS 693
            |||||:||...:::.||.||....|:.|.::.......|...| .:|:.|:...||||.||.:
 Worm   790 LTGTPLQNNLEELFHLLNFLAPDRFNQLESFTAEFSEISKEDQIEKLHNLLGPHMLRRLKADV-- 852

  Fly   694 DGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQ 758
               |..:|:|:..::.:.|...:...|:.::|.:                            ::.
 Worm   853 ---LTGMPSKQELIVRVELSAMQKKYYKNILTRN----------------------------FDA 886

  Fly   759 IKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSSD 823
            :...||             |::.     .::.:::.|::.|.||.|.
 Worm   887 LNVKNG-------------GTQM-----SLINIIMELKKCCNHPYLF------------------ 915

  Fly   824 SDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRP 888
                   :.|.|....:.:...:|...:.|||
 Worm   916 -------MKACLEAPKLKNGMYEGSALIKNAG--------------------------------- 940

  Fly   889 SSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNE 953
              |..::.::|:.  ||....:.::.||.|.:||||.|....:|.....::|:|..:.|||.::.
 Worm   941 --KFVLLQKMLRK--LKDGGHRVLIFSQMTMMLDILEDFCDVEGYKYERIDGSITGQQRQDAIDR 1001

  Fly   954 FNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMC 1018
            :|....::.|.|||..|||:|:||..|:.:::.|..|||..:.||..|.:|:|||..|:||:|:.
 Worm  1002 YNAPGAKQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRLGQKHKVMIYRFVT 1066

  Fly  1019 VDTVEQRIKGLQDKKLDLADGVL---TGA---KVSSKLTIDDL 1055
            ..:||:||..:..||:.|...|:   .||   |..||..:||:
 Worm  1067 KGSVEERITSVAKKKMLLTHLVVRAGLGAKDGKSMSKTELDDV 1109

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	171/803 (21%)
		DEXHc_TTF2	439..686	CDD:350830	63/271 (23%)
chd-3	NP_510140.1	CHDNT	97..150	CDD:462357
		TNG2	<180..311	CDD:227367	22/120 (18%)
		PHD1_CHD_II	268..309	CDD:277006	9/40 (23%)
		PHD2_CHD_II	330..372	CDD:277007	10/41 (24%)
		CD1_tandem_CHD3-4_like	377..460	CDD:349314	15/98 (15%)
		CD2_tandem_CHD3-4_like	498..552	CDD:349309	8/53 (15%)
		PLN03142	564..>1129	CDD:215601	160/734 (22%)
		DUF1087	1199..1248	CDD:461922
		CHDII_SANT-like	1299..1418	CDD:461920
		CHDCT2	1512..1662	CDD:462358