Protein Alignment lds and let-418

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_504523.1
• Gene: let-418 / 178970
• WormBaseID: WBGene00002637
• Length: 1829
• Species: Caenorhabditis elegans
• Alignment Length: 1283
• Identity: 245/1283 - (19%)
• Similarity: 431/1283 - (33%)
• Gaps: 493/1283 - (38%)

  Fly    52 DETQSEEEESQSSETAESEKSDES------DNSQNSQESEDSEDDSVRPSARNTKRK----PLGI 106
            :||:.|||:.|..|...||:...|      ...:.|::|..:......|...|:..:    .:|:
 Worm    27 EETEEEEEQEQGDEAGPSERKRSSRKKGGKGGKKGSKKSAAAASKVEIPDPYNSTSEEVCAAIGL 91

  Fly   107 PSDSEDEEDELEQRALSP-STRMSITGVRPQDLSDDDS----------EIEYSD----------- 149
             :|.|.:.||.|.:.:|. .|..||  ::||.|..:..          :::|.:
 Worm    92 -TDVEFDYDEEEFQGISNLKTFSSI--IKPQILEANPGTNVSKMYPMFQVKYKEYQDHMAAQGKP 153

  Fly   150 ---EVQEGPTEAPTAEAVVPRYT---TQFAGNIQNDLHSTIGAADSEVLDDSSGSDVLILSNKET 208
               :.:...|.|.:...:.||..   |:.|...:.         ||:..|.....:..|...::.
 Worm   154 VQKQARGSKTPAVSTPVIPPRSAPTKTRSARRKRR---------DSDAPDSDQEFEAFIKQQEQL 209

  Fly   209 PIEILSSTDD--------------------------------DATTN------------------ 223
            ..:::...:|                                :|..|
 Worm   210 EDDLVKDKEDARIKRAAEREEKKKGALEAARAAKKAKLEKGEEAENNDYCEECKQDGELLLCDTC 274

  Fly   224 ---------KENMSGPP-----------------FERPSKSLSPRSSAGASVVKTSKNL------ 256
                     .|||..||                 .|.|:|    ::.....:.|.::||
 Worm   275 PRAYHTVCIDENMEEPPEGDWSCAHCIEHGPEVVKEEPAK----QNDEFCKICKETENLLLCDSC 335

  Fly   257 --------SQPTIQAVLKQKTSPAAPRRSRIKSED--QKVV----SQVVYDEEM----------- 296
                    ..|.:..|.|::|. :.||...:|.|.  :|::    .::.|.|.:
 Worm   336 VCSFHAYCIDPPLTEVPKEETW-SCPRCETVKPEHKIEKILCWRWKEIPYPEPLEAGKEASSDDA 399

  Fly   297 -----RKLAEKR-----------------------VQV--------------SDAEKLFEKVA-- 317
                 ||:..:|                       ::|              |||...||:..
 Worm   400 MLKPPRKMEPRREREFFVKWKYLSYWQCSWVSEMLLEVHFRMLILLYWRKNDSDAPPEFEESVTS 464

  Fly   318 -HKLPDKGSQIMKRIDTLRRELAMDEQWISALRV--QQSNVPAVR--VVKPTLNPPRAPSIDTLD 377
             |...:...::.:|.    .:..:..:|:...|:  .||...:.:  :||
 Worm   465 RHHSDNDPYKLRERF----YQYGIKPEWMQIHRIINHQSYAKSQQDYLVK--------------- 510

  Fly   378 WDELS-----------------EAV-----------NEIKP--------VYTGAQGMATFNNQKA 406
            |.|||                 ||:           ||..|        .:..|:|:....::|.
 Worm   511 WKELSYDQATWERDDSNIANYEEAIIKYWQHRESKLNEDIPKNVQKMIAKHREAKGLPPKEDEKK 575

  Fly   407 LTLESLKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAWM--SWRERKLPRGGILADDMGL 469
            .......|:....|  ..|:.:.|  .|.|  |..:|...|.|:  .|..   ....||||:|||
 Worm   576 KKKREKIDIRKKYE--VQPDYVTE--TGGK--LHPYQLEGLNWLRHCWSN---GTDAILADEMGL 631

  Fly   470 GKT---LTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVC 531
            |||   ||.:.|:        |.||.                              .:|..|:..
 Worm   632 GKTVQSLTFLYSL--------MKEGH------------------------------CKGPFLIAA 658

  Fly   532 PASLLRQWESEVES------------------------------------KVSRQKLTVCVHHGN 560
            |.|.:..||.|.|.                                    |.|:.|.|      .
 Worm   659 PLSTIINWEREAEQWCPDFYVVTYVGLRDARVVLREHEFSFVEGAVRSGPKASKMKTT------E 717

  Fly   561 NRETKGKYLRDYDIVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGK 625
            |.:        :.:::|:|:.:..:...||:   ::|..:::||||.::|::|.....:.:....
 Worm   718 NMK--------FHVLLTSYETINMDKTILSS---IEWGALVVDEAHRLKNNQSLFFKNLNEYTIH 771

  Fly   626 YRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAGGQ-NRLNLLMKSLMLRRTKA 689
            ||..|||||:||...:::.||.||....|:.|..:....:..|...| .:|:.|:...||||.||
 Worm   772 YRVLLTGTPLQNNLEELFHLLNFLSKERFNQLEAFTAEFNEISKEDQIEKLHNLLGPHMLRRLKA 836

  Fly   690 QLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKP 754
            .:     |..:|:|...::.:.|...:...|:.::|.:
 Worm   837 DV-----LTGMPSKSELIVRVELSAMQKKWYKNILTRN--------------------------- 869

  Fly   755 TYNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGL-IDAMLDGEESQTMG 818
             ::.:...||             |::.     .::.:|:.|::.|.||.| :.|.|:..:.:
 Worm   870 -FDALNVKNG-------------GTQM-----SLMNVLMELKKCCNHPYLFVKAELEAPKEK--- 912

  Fly   819 DHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVF 883
                                              |...:|..|:.:..:.....|.|.|
 Worm   913 ----------------------------------NGMYEGTALIKNSGKFVLLQKMLRK------ 937

  Fly   884 NLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQ 948
                                ||....:.::.||.|.:|||:.|....:|.....::|:|..:.||
 Worm   938 --------------------LKDGGHRVLIFSQMTRMLDIMEDLCEYEGYRYERIDGSIMGQMRQ 982

  Fly   949 DIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVII 1013
            |.::.:|....|:.:.|||..|||:|:||..|:.:::.|..|||..:.||..|.:|:|||..|:|
 Worm   983 DAIDRYNAPGAQQFIFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRLGQKHKVMI 1047

  Fly  1014 YKFMCVDTVEQRIKGLQDKKLDLADGVLTG------AKVSSKLTIDDL 1055
            |:|:...:||::|..:..||:.|...|:..      .|..||..:||:
 Worm  1048 YRFVTKKSVEEKITSVAKKKMLLNHLVVRAGLGGKEGKTMSKTELDDV 1095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	178/896 (20%)
		DEXHc_TTF2	439..686	CDD:350830	66/288 (23%)
let-418	NP_504523.1	CHDNT	95..147	CDD:462357	12/53 (23%)
		PHD1_CHD_II	258..300	CDD:277006	5/41 (12%)
		RanBP2-type Zn finger	295..323	CDD:275375	3/31 (10%)
		PHD_SF	320..362	CDD:473978	8/42 (19%)
		CD1_tandem_CHD3-4_like	370..448	CDD:349314	7/77 (9%)
		CD2_tandem_CHD3-4_like	486..539	CDD:349309	12/67 (18%)
		PLN03142	590..>1114	CDD:215601	151/682 (22%)
		DUF1087	1188..1235	CDD:461922
		CHDII_SANT-like	1276..1406	CDD:461920
		CHDCT2	1525..1673	CDD:462358