Protein Alignment lds and swsn-4

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_502082.1
• Gene: swsn-4 / 178015
• WormBaseID: WBGene00004204
• Length: 1474
• Species: Caenorhabditis elegans
• Alignment Length: 1194
• Identity: 254/1194 - (21%)
• Similarity: 435/1194 - (36%)
• Gaps: 385/1194 - (32%)

  Fly    44 PSSAGVVIDETQSEEEESQSSETAESEKSDESDNSQNSQESEDSEDDSVRPSARNTKRK-PLGIP 107
            |..||.|:.:...:..:.|....::.|      |:..|.|.:..::|.....|...|:| ..|:|
 Worm    15 PQPAGEVVAQQAGDGAQGQELTISKLE------NAITSMEEQGLQNDHRHAKAVLLKQKLQSGLP 73

  Fly   108 SDSEDEEDELEQRALSPS----TRMSITGVR--------PQDLSDD------------DSEIEYS 148
            .....:|:...|: ::|:    .|..::..|        |.:|..|            ....||.
 Worm    74 DAVPGQENGGNQQ-ITPAQLNQLRAQVSAYRLLARNEQVPANLIADAVMLRPKVTTLLPEPYEYP 137

  Fly   149 DEVQEG--------------------PTEAPTAEAVVPRYTTQFAGNI---QNDLHSTIG----- 185
            .|.:.|                    ||.......:.|      .|.:   :|.:.:.||
 Worm   138 GEAENGEKLPYDLMKIFNLHQIRCNRPTTISVPSGIDP------VGMLKQRENMIQNRIGLRMKL 196

  Fly   186 -------AADSEVLDDSSGSDVLILSNKETPI--EILSSTDDDATTNKENMSGPPFERPSKSLSP 241
                   ..|...|........|.|.|.:|.:  |:::....|.|.  |....|...|.:|..|.
 Worm   197 LNNLPADIPDHMKLKAEIELRALRLVNLQTQVRSEVMACLKRDTTL--ETALNPYAYRRTKRQSL 259

  Fly   242 RSSAGASVVKTSKNLSQ---------PTIQAV---------------LKQKTSPAA-------PR 275
            |.:.....::..:.:.|         ..:||:               ||...|..|       ..
 Worm   260 REARVTEKLEKQQKMEQERKRRQKHTDLMQAIIQHGKEFKEYHRNNLLKMAKSRKAVMTYHQNNE 324

  Fly   276 RSRIKSE-----------------------DQKVVSQVVY-----DEEMRKLAEKRVQVSDAEKL 312
            |.|.|.|                       |:|...::||     ||.:..|.....|..:.||.
 Worm   325 RERKKDEIRNEKLRMQKLMQEDEEGYRALLDEKKDQRLVYLLQQTDEYVDSLCSLVRQHQNTEKK 389

  Fly   313 FEKVAHKLPDKGSQIMKRIDTLRRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPSIDTLD 377
            .:|...|: :||:|             |||:  :.:.|::      |.....|...:||..:.::
 Worm   390 KKKEDKKI-EKGNQ-------------MDEE--ARVHVRE------RSTGKALTGDQAPKTEEIE 432

  Fly   378 -W------------DELS---EAVNEIKPV---------YTG-------------AQGMATFNNQ 404
             |            |:||   |...|..||         |.|             |:......:|
 Worm   433 FWLETHPEYEIVPRDQLSDDEEEEEEEAPVEPEEEKDDQYAGMDEETKAKMILEKARNEEDEYDQ 497

  Fly   405 KALTLESLKDLHVSLEDLPGPEVLAEDPVG---LKVSLMNHQKHALAWM-SWRERKLPRGGILAD 465
            |  |.:.:.|.:.:...:....|.....:|   ..:.|..:|...|.|| |.....|  .|||||
 Worm   498 K--TKKQMADYYATAHKIKEKVVKQHTTMGGGDPNLLLKPYQIKGLEWMVSLYNNNL--NGILAD 558

  Fly   466 DMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVV 530
            :||||||:..||.|      ..:.|.|..:                             |..||:
 Worm   559 EMGLGKTIQTISLV------TYLMEVKQNN-----------------------------GPYLVI 588

  Fly   531 CPASLLRQWESEVESKVSRQKLTVCVHHGN---NRETKGKYLRD-YDIVVTTYQIVAREHKSLSA 591
            .|.|.|..|::|.....  ..:|..::.|.   .|..:|:..:. :::::|||:.|.:|    .|
 Worm   589 VPLSTLSNWQNEFAKWA--PSVTTIIYKGTKDARRRVEGQIRKGAFNVLMTTYEYVIKE----KA 647

  Fly   592 VFG-VKWRRIILDEAHVVRNHKSQSSLAVCDLRG----KYRWALTGTPIQNKELDVYALLKFLRC 651
            :.| ::|:.:|:||.|.::||..:.:|.   |.|    ::|..|||||:|||..:::|||.||..
 Worm   648 LLGKIRWKYMIIDEGHRLKNHNCKLTLM---LNGFFHAQHRLLLTGTPLQNKLPELWALLNFLLP 709

  Fly   652 SPFDDLHTWKKWIDNKSA-GGQ-------------NRLNLLMKSLMLRRTKAQLQSDGKLNSLPN 702
            |.|....|:::|.:...| .|:             .||:.:::..:|||.|.:::|     .||:
 Worm   710 SIFSSCGTFEQWFNAPFATTGEKVELNQEETMLIIRRLHKVLRPFLLRRLKKEVES-----QLPD 769

  Fly   703 KELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQIKDPNGAYY 767
            |...:|     |.:.:..|.|:                      ||
 Worm   770 KTEYVI-----KCDQSALQKVI----------------------YR------------------- 788

  Fly   768 KMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSSDSDTPEIDLL 832
              |.:...:..:|....:..::..::.||::|.||.|...:.|...:..
 Worm   789 --HMQKGLLLDAKMSSGARSLMNTVVHLRKLCNHPFLFPNIEDSCRAYW---------------- 835

  Fly   833 AQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRPSSKINMVIQ 897
             ::|::..||                                          |.|.:.|:.::.:
 Worm   836 -KVNEVNGTD------------------------------------------LMRVAGKLELLDR 857

  Fly   898 ILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKR 962
            ||..  ||::..:.::..|.||:::|..|.|:......|.|:|:.....|.|::.:||..|:...
 Worm   858 ILPK--LKATGHRILMFFQMTSMMNIFEDFLNFRRYTYLRLDGSTKPDERGDLLTQFNAPNSDLF 920

  Fly   963 VLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIK 1027
            :.:||..|||:||||..|:.:::.|..|||..:.|||||.:|:||||.|.:.:.:..::||::|.
 Worm   921 LFMLSTRAGGLGLNLQTADTVIIFDSDWNPHQDMQAQDRAHRIGQKKEVRVLRLITANSVEEKIL 985

  Fly  1028 GLQDKKLDLADGVLTGAKVSSKLT 1051
            .....||::.:.|:...|...:.|
 Worm   986 AAARYKLNVDEKVIQAGKFDQRST 1009

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	189/823 (23%)
		DEXHc_TTF2	439..686	CDD:350830	75/270 (28%)
swsn-4	NP_502082.1	QLQ	88..116	CDD:462622	4/27 (15%)
		HSA	272..344	CDD:214727	11/71 (15%)
		BRK	403..446	CDD:462196	9/50 (18%)
		PLN03142	472..1288	CDD:215601	163/700 (23%)