Protein Alignment lds and T05A12.4

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_001023359.1
• Gene: T05A12.4 / 177453
• WormBaseID: WBGene00020235
• Length: 1622
• Species: Caenorhabditis elegans
• Alignment Length: 893
• Identity: 170/893 - (19%)
• Similarity: 307/893 - (34%)
• Gaps: 301/893 - (33%)

  Fly   276 RSRIKSEDQKVVSQVVYDEEMRKLAEKRVQVSDAEKLF-------EKVAHKLP-------DKGSQ 326
            |..||.::::.......|.|:....::|.:..:.|:.|       :|..|::|       |....
 Worm   163 RDIIKGDEKETPFDPNDDNEVDNCEQRRQEDMNFEQFFTYINVYKDKHDHQIPNFKLNESDLNCD 227

  Fly   327 IMK-RIDTLRRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPSIDTLDWDELSEAV-NEIK 389
            :|: :.||:|        |:....:..         :|..|         ::|...||.: ::..
 Worm   228 LMQYQKDTVR--------WMLYRELNH---------EPDGN---------IEWMIKSEKLASDTS 266

  Fly   390 PVYTGAQGMATFNNQKALTLESLKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAWMSWRE 454
            .||..:.|....|.   :|:|..||:                                     .:
 Worm   267 LVYYPSIGAIALNE---MTIEERKDI-------------------------------------EK 291

  Fly   455 RKLPRGGILADDMGLGKTLTMISSV----------LACKNGQEMSEGKDESSDSDSE-------- 501
            |...:||||||:||||||:..:|.:          :..::|:..:..:|||..::|.
 Worm   292 RFTLKGGILADEMGLGKTIQALSLIATNRKHSKVEIYDESGEVETVNRDESKSTNSSIAQQIKLA 356

  Fly   502 -----DDKNKKRK----------------------------SVTGW---KSKGRK---------- 520
                 :.|..::.                            .:.||   |.|..|
 Worm   357 ESSYAEMKGARQNQADIRYNLNSFCDGETILCSNCSQMCSAKICGWDFDKFKNEKFQCSKCTSES 421

  Fly   521 DTRR--GGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKYLR-----DYDIVVTT 578
            :.||  |.||::.|.||:.||.:|: ||.....:.|..:.|..   |..||:     .||:::||
 Worm   422 ENRRAVGTTLIILPESLIFQWFTEI-SKHCSDNIKVMFYFGIR---KHGYLQPCEMDSYDVILTT 482

  Fly   579 YQI----------------VAREHKSL---SAVFGVKWRRIILDEAHVV-RNHKSQSSLAVCDLR 623
            |..                :..|.|:|   |::..|::.|||:||:.|: ....||.:..:..|.
 Worm   483 YDTLRNEMSFSEEKGPPRNLRNESKTLNLTSSLMHVEFWRIIVDESQVLPHGVSSQLTRMLMKLH 547

  Fly   624 GKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAGGQNRLNLLMKSLMLRRTK 688
            .:..|.:||||:......:|.|..||...||.....:.:::..:..
 Worm   548 AENWWCVTGTPLVKSIAGIYPLFNFLNLFPFGSPQFFSQYVHPQYL------------------- 593

  Fly   689 AQLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANK 753
                         |..|.|.:.:|||..:         .|....:.|.:...|:|..:.......
 Worm   594 -------------NFALSLRDEALDKNNL---------PRVFLLEILSKMMSRKTKQDKSVQLKL 636

  Fly   754 PTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMG 818
            |...:::  ...|:...|:  |....:||           |||.|     :..|:.:.:.|..:.
 Worm   637 PKLTEVE--KIIYFTTVEE--RQYKDEKE-----------RLRNI-----VERAIGNADNSDLLS 681

  Fly   819 D-HSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPV 882
            | ...:....|:.||.|:..|....|.:|....|          |..|..|.|..||........
 Worm   682 DLQCREKVLQELRLLRQIILLGQRKTESDKVSCV----------LAPETVIFKLIKNKKTTIKAN 736

  Fly   883 FNLHRPSSKINMVIQILK----------TSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLS 937
            |..:...|.....:|||.          :|.|.:.|:  :::::...:.:|..|....|....|.
 Worm   737 FREYLSYSLGVAGVQILMDMPQTAIETYSSALINYDE--LILAERNHLPEIKNDSSRDDSPCLLE 799

  Fly   938 L----------NGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNP 992
            .          :|:...|.:.:.:||.|.        .|.      |::.|...::...:|:.:|
 Worm   800 EDEDDDFDGEDDGSAEKKKKPNKLNELNG--------FLG------GIHQISKKYMKSKNLNLDP 850

  Fly   993 QLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQ--RIKGLQDKKLDLAD 1038
              .::..:|..||.:::            :|:  |.|..:..:||:.:
 Worm   851 --TSRKSERNGRVNERE------------IEEITRPKDAKRSRLDVEE 884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	167/882 (19%)
		DEXHc_TTF2	439..686	CDD:350830	73/337 (22%)
T05A12.4	NP_001023359.1	DEXDc_SHPRH-like	296..624	CDD:350766	80/372 (22%)
		RING_Ubox	1345..1393	CDD:473075
		SF2_C_SNF	1418..1548	CDD:350180