Protein Alignment lds and smrd-1

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_499301.2
• Gene: smrd-1 / 176462
• WormBaseID: WBGene00010845
• Length: 989
• Species: Caenorhabditis elegans
• Alignment Length: 1095
• Identity: 262/1095 - (23%)
• Similarity: 434/1095 - (39%)
• Gaps: 281/1095 - (25%)

  Fly    29 SSRLSKSSRLSKSSRPSSAGVVIDETQ-------SEEEESQSSETAESEKSDESDNSQNSQESED 86
            |..|:.....::..|.:..|:...|.:       .:::|....||..||..::.||::..::.:|
 Worm    38 SQNLNNGHLTARPPRTTGPGIKYGEKKPKKQKGSDDDDEDYVDETMPSEDEEDFDNNEEDEDDDD 102

  Fly    87 SEDDSVRPSARNTKRKPLGIP------SDSEDEEDELEQ-RALSPSTRMSITGVRPQDLSDDDSE 144
            .|::..|.....:|:| |..|      .|||..|.|::: |.||             |.|||
 Worm   103 YEEEGPRKRKAPSKKK-LVYPRENYRREDSETPEPEMKRIRTLS-------------DSSDD--- 150

  Fly   145 IEYSDEVQEGPTEAPTAEAVVPRYTTQFAGNIQNDLHSTIGAADSE--VLDDSSGSDVLILSNKE 207
             |:..:.:...:|:|             .||:.....:...||...  |:||.|..|.:
 Worm   151 -EWMTKPRLNGSESP-------------IGNVMRTQMAKRSAASKRKIVIDDESEDDFI------ 195

  Fly   208 TPIEILSSTDDDATTNKENMSGPPFERPSKSLSPRSSAGASVVKTSKNLSQPTIQAVLKQKTSPA 272
                    .|::.:   |..||...|:.....|.:.|              .|.:..:||..|..
 Worm   196 --------NDEEIS---EKGSGKGSEKEESEGSGKDS--------------ETEEVTMKQGQSLK 235

  Fly   273 APRRSRIKSEDQKVVSQVVYDEEMRKL-AEKRVQVSDAEKLFEKVAHKLPDKGSQIMKRIDTLR- 335
            |......|.:.:|..|...::|:...: |:.....||...:.|:.|           ||.:|..
 Worm   236 AAMAKAQKEQKKKAESDEDWEEDEDDMNADGDETPSDDSDIEERRA-----------KRGETKNQ 289

  Fly   336 ---REL---AMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTG 394
               ||.   |..|..:...|:.......|...:|              ::.....|.::|.|..|
 Worm   290 KECREFFNKAKKEDLLQQARINDKIADFVLANRP--------------FEIYGAMVAKMKGVTRG 340

  Fly   395 AQGMAT---FNNQKAL---TLESLKD-LHVSLEDLPGPEVLAEDPVGLKV-----SLMNHQKHAL 447
            ...:..   |..::.:   .|:..|| .|...:|.   |...|.|:.|.:     :|.::|...:
 Worm   341 TNAIEAYMEFLEKRGILSRILDDCKDHAHTVTKDF---ERCTEGPLQLPLLKEGCTLHDYQLIGV 402

  Fly   448 AWMSWRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVT 512
            .|:.....| ....||.|:||||||:.:::.:...|     ..||
 Worm   403 KWLIMMYNK-DLNAILGDEMGLGKTIQIVAFLSYLK-----QIGK-------------------- 441

  Fly   513 GWKSKGRKDTRRGGTLVVCPASLLRQWESEVESKV-SRQKLTVCVHHGNNRETKG-----KYLRD 571
                       .|..|:|.|:|.:..|..|..... |.|.||   ::|:..|.|.     |..:|
 Worm   442 -----------TGPHLIVVPSSTIENWIGEFHKWCPSIQLLT---YYGSQDERKHLRHRVKKQKD 492

  Fly   572 Y-DIVVTTYQIVA--REHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGT 633
            : |:::|||.:|.  .:.|.....|.:.:  :|.||.|:::|..|:....:..::||.:..||||
 Worm   493 HIDVILTTYNMVTSKSDDKKFFKNFSLNY--VIYDEGHMLKNCDSERYRGLMKVKGKKKILLTGT 555

  Fly   634 PIQNKELDVYALLKFLRCSPF-----DDLHTWKKW------ID--NKSAGGQNRL---NLLMKSL 682
            |:||..:::.:|:.|:....|     |..|..:.:      :|  ||:...|:|:   ..:::..
 Worm   556 PLQNNLIELISLMYFVLSKVFNKYCEDITHLLQHFKQLGPALDTKNKALYQQDRIEEAKAILQPY 620

  Fly   683 MLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNY 747
            :|||.|.|:     |.|||:|..::||:.:.|.:..:|..::        :.|.|..|
 Worm   621 ILRRLKNQV-----LGSLPSKSEQIIEVEMKKPQKQLYDNIV--------EALQQSEE------- 665

  Fly   748 RSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGE 812
                           :|..|          ||            |:||||...||.|
 Worm   666 ---------------SGDSY----------GS------------LMRLRQAANHPLL-------- 685

  Fly   813 ESQTMGDHSSDSDTPEIDLLAQ---LNKLAITDTSTDG-QQSVANAGDDGPPLLPDEARIAKASK 873
                   ..|:....::|.:|:   |.:.|..|..... .:.:|...|.....|.:..|.  .||
 Worm   686 -------RRSEYTDQKLDKIAKMLCLREKAYADKKWQHVSEDLAWLSDIKIHQLCERFRC--TSK 741

  Fly   874 NLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSL 938
            .||..     .|...|.|... :.::...|.|.. ||.::.||:||:||||..:|:..|.:...|
 Worm   742 FLLNE-----QLALKSGKCEQ-LDVMLPEIQKKG-DKVLIFSQFTSMLDILEVYLNIRGYSYKRL 799

  Fly   939 NGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIY 1003
            :|..||.:||:::|||| .:....|.|||..|||:|:||..|||:::.|:.:||..:.||:||.:
 Worm   800 DGQTPVLDRQEMINEFN-LSKDLFVFLLSTRAGGLGINLTSANHIIIHDIDFNPYNDKQAEDRCH 863

  Fly  1004 RVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVLTGAKVSSKLTIDDLKGL 1058
            |:||:|.|.:.:.:...|||..:..|..|||.|...|..|.|  .:|..|.|:.|
 Worm   864 RMGQEKPVHVTRLVSKGTVEVGMLALAKKKLQLEKQVTDGVK--GQLDEDALREL 916

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	198/802 (25%)
		DEXHc_TTF2	439..686	CDD:350830	65/271 (24%)
smrd-1	NP_499301.2	HepA	<393..902	CDD:440319	168/632 (27%)