Protein Alignment lds and chd-1

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_491994.2
• Gene: chd-1 / 172432
• WormBaseID: WBGene00010369
• Length: 1461
• Species: Caenorhabditis elegans
• Alignment Length: 1099
• Identity: 232/1099 - (21%)
• Similarity: 405/1099 - (36%)
• Gaps: 309/1099 - (28%)

  Fly     3 SENSEYYSDKEEDSVVNNSSLGRSRKSSRLSKSSRLSKSSRP-------SSAGVVIDETQSEEEE 60
            :..||...:||:.:....||..:|..|...|::|..|:...|       ::.|:..:..:..|.|
 Worm    32 NSTSEDNDEKEKAADSPESSSDQSDDSDDASENSSSSEPDEPAPKKKNNNNRGMDAETRKLLENE 96

  Fly    61 SQSSETAESEKSDE--SDNSQNSQESEDSEDDSVRPSARNTKRKPLGIPSDSEDEEDELEQRALS 123
            :....:..|::.|:  ||||:.||.|||..||..:|....||:..            :..::|:|
 Worm    97 NYFRRSKRSKRQDDSPSDNSEESQSSEDDWDDRRKPRRTVTKKVV------------KQTKKAVS 149

  Fly   124 PSTRMSITG------VRPQDLSDDDSEIEYSDEVQEGPTEAPTAEAVVPRYTTQFAGNIQNDLHS 182
            ...|.|:.|      ....|..|||..:|:.:|        |...|..|...|:....:....|.
 Worm   150 VVKRKSVKGNVNYAEKNSDDDIDDDDVLEWDEE--------PAVPAEGPAILTETVERVIKWRHG 206

  Fly   183 TIGAADSEVLDDSSGSDVLILSNKETPIEILSSTDDDATTNKENMSGPPFERP--------SKSL 239
            ..||.       .|.:....:::|..|              .:.:.|...|:.        |...
 Worm   207 VPGAT-------GSATTCYNIADKGDP--------------NDQIPGDKTEQQFFVKWTGWSHLH 250

  Fly   240 SPRSSAGASVVKTSKNLSQPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRV 304
            :...|..:..:..:|.|.:  :|..:|::......:||..|       ..:.:.|..:::||:..
 Worm   251 NTWESENSLALMNAKGLKK--VQNYVKKQKEVEMWKRSADK-------EYIEFFECEQQMAEELC 306

  Fly   305 QVSDAEKLFEKVAHKLPDKGSQIMKRIDTLRRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPR 369
            :  :.:|:...|||:              ..|:.|.|....:...::.|.:|
 Worm   307 E--EYKKVERVVAHQ--------------TSRDRAADGSMATEYLIKWSGLP------------- 342

  Fly   370 APSIDTLDW-DELSEAVNEIKPVYTGAQGMATFNN-----QKALTLESLKDLHVSLEDLPGPEVL 428
               .....| ||...|..:||..|...:.:.:.|.     :|....|..:.:         |:.|
 Worm   343 ---YSDCTWEDEKMVAPEQIKAYYHRIENLKSPNKNSNVLRKRPKFEKFESM---------PDFL 395

  Fly   429 AEDPVGLKVSLMNHQKHALAWM--SWRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEG 491
            ..|..... .|.::|...|.||  :|.:   ....||||:||||||:..||.:.:..:..:::
 Worm   396 KTDGESTH-KLRDYQLEGLNWMVYAWCK---GNSSILADEMGLGKTIQSISLLASLFHRYDLA-- 454

  Fly   492 KDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCV 556
                                             |..|||.|.|.:..|:.|.........|.|.:
 Worm   455 ---------------------------------GPYLVVVPLSTMAAWQKEFAQWAPEMNLVVYM 486

  Fly   557 HHGNNRETKGKYLRDYD------------IVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVVR 609
            ....:|:    .:|.|:            .::|||:|:.::...||:   :.|..:::||||.::
 Worm   487 GDVVSRD----MIRQYEWFVGGTKKMKINAILTTYEILLKDKAFLSS---IDWAALLVDEAHRLK 544

  Fly   610 NHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAGGQNR 674
            |.:|....::...|..::..:||||:||...:::|||.|:....||   .|:::....:......
 Worm   545 NDESLLYKSLTQFRFNHKLLITGTPLQNSLKELWALLHFIMPEKFD---CWEEFETAHNESNHKG 606

  Fly   675 LNLLMKSL---MLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLH 736
            ::.|.|.|   :|||.|..::     .|||.|..:::.:.:...:...|:.::|.
 Worm   607 ISALHKKLEPFLLRRVKKDVE-----KSLPPKTEQILRVDMTAHQKQFYKWILTK---------- 656

  Fly   737 QRAERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCH 801
                     ||| :.:|.....|   ||                       .:.|::.|::.|.|
 Worm   657 ---------NYR-ELSKGVKGSI---NG-----------------------FVNLVMELKKCCNH 685

  Fly   802 PGLIDAMLDGEESQTMGDHSSDSDTPEI-DLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDE 865
            ..|          ....||..|.....: .||....||.:.|
 Worm   686 ASL----------TRQYDHIYDDAQGRLQQLLKSSGKLILLD----------------------- 717

  Fly   866 ARIAKASKNLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSK 930
                    .||.|                         ||....:.::.||...:||||:::|..
 Worm   718 --------KLLCR-------------------------LKDKGHRVLIFSQMVMMLDILQEYLQL 749

  Fly   931 DGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLE 995
            ....:..|:|::....|:..::.:|...:.....|||..|||:|:||..|:.:::.|..||||.:
 Worm   750 RRFPSQRLDGSMRADLRKQALDHYNAPGSTDFAFLLSTRAGGLGINLATADTVIIFDSDWNPQND 814

  Fly   996 AQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVL-----TGAKVSSK 1049
            .||..|.:|:||.|.|.||:.:...:||:.|.....:||.|...|:     ||..|.||
 Worm   815 LQAMSRAHRIGQTKTVNIYRLVTKGSVEEEIVERAKRKLVLDHLVIQRMDTTGKTVLSK 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	163/777 (21%)
		DEXHc_TTF2	439..686	CDD:350830	62/263 (24%)
chd-1	NP_491994.2	CD1_tandem_CHD1-2_like	194..275	CDD:349313	14/103 (14%)
		CD2_tandem	308..363	CDD:349306	15/84 (18%)
		PLN03142	404..1245	CDD:215601	144/635 (23%)
		DUF4208	1298..1367	CDD:464035