DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lds and T23H2.3

DIOPT Version :9

Sequence 1:	NP_524850.2	Gene:	lds / 45894	FlyBaseID:	FBgn0002542	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001032980.2	Gene:	T23H2.3 / 172347	WormBaseID:	WBGene00020742	Length:	1001	Species:	Caenorhabditis elegans

Alignment Length:	1134	Identity:	336/1134 - (29%)
Similarity:	513/1134 - (45%)	Gaps:	226/1134 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSENSEYYSDKE---EDSVVNNSSLGRSRKSSRLSKSSRLSKSSRPSSAGVVIDETQSEEE---E 60
            ||::||....||   ..|.|:.::..||..||...::  :..:|..|.|..|...|.:.::   .
Worm    13 SSDSSEDEDRKERHSSSSEVDETASMRSTDSSEPPRT--IIDASLNSMASTVYTSTPNSKQSISR 75

  Fly    61 SQSSETAESEKSDESDNSQNSQESEDSEDDSVRPSARNTKRKPLGIPSDSEDEEDELEQRALSPS 125
            :.||.|..|.|....|:.::....::|.:..|.|..:..:.      ||....:.:|.:|.|
Worm    76 TGSSTTYGSSKCSTDDHYRSRSFIDNSFEKPVTPITKKLQE------SDEPRAKQQLRERLL--- 131

  Fly   126 TRMSITGVRPQDLSDDDSEIEYSDEVQEGPTEAPTAEAVVPRYTTQFAGNIQNDLHSTIGAADSE 190
             |.||.....|||:...|                                     .|..|..::.
Worm   132 -RKSIKQQSDQDLTGGSS-------------------------------------RSGWGTGENS 158

  Fly   191 VLDDSSGSDVLILSNKETPI----EILSSTDDDATTNKENMSGPPFERPSKSLSPRSSAGASVVK 251
            .|:.|.     ::::..:||    ...|..||...|:      ||   |::|..|.       |:
Worm   159 SLESSD-----LINSHFSPIAKTFRHASDLDDSMNTS------PP---PNRSTLPS-------VE 202

  Fly   252 TSKNLSQPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRVQVSDAEKL-FEK 315
            ||...|        .|...|.:|..|...|..:...|      |::||:.|.::.:..:|| ..|
Worm   203 TSSGNS--------PQTPYPGSPEASPQPSPPKNTAS------ELQKLSIKELEANKDKKLKLLK 253

  Fly   316 VAHKLPDKGSQIMKRIDTLRRELAMDEQWISALRVQQSNVPAVRVVKPT-LNPPRAPSIDTLDWD 379
            .:..|||.|:::..::|.:..|:..        |:.......:.|.|.| :.||..|.
Worm   254 FSSNLPDNGARVKLQVDEITEEIER--------RIINGVTDTMVVDKTTAIPPPPQPK------- 303

  Fly   380 ELSEAVNEIKPVYTGAQGMATFN----------NQKALTLESLKD-LHVSLED----LPGPEVLA 429
                  |.|.|:......|...|          .||.|.:..:.| |...|.|    :|....|.
Worm   304 ------NLIAPIPQDFAAMLDKNGRKVMSGRMTEQKILKVNKISDRLMQQLADATHTIPAETDLT 362

  Fly   430 EDPVGLKVSLMNHQKHALAWMSWRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEMSEGKDE 494
            :.|.||.|.||.|||..|.|:.|||.:...||||||||||||||:|:|.::..|..:   ..:.|
Worm   363 DTPDGLLVELMPHQKAGLRWLVWREGQPHSGGILADDMGLGKTLSMLSLIVHQKAAR---RARKE 424

  Fly   495 SSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHG 559
            |.|:.:  ||.|:|.:    |.:|...:  .|||::.||||:.|||:|:..::....|:|.:.||
Worm   425 SGDNAA--DKEKRRVA----KEEGLYPS--NGTLIIAPASLIHQWEAEINRRLESDLLSVFMFHG 481

  Fly   560 --NNRETKGKYLRDYDIVVTTYQIVARE-----------------------------HKSLSAVF 593
              ..|:.:.|.|..||:|:|||.:.|.|                             .|:.|.:.
Worm   482 TKKQRQIEPKELARYDVVITTYTLAANELMEKKAAGSKKEEDSDDESENEENPRRPAGKNDSPLA 546

  Fly   594 GVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLH 658
            .|.|.|:||||||.::|..||.|.|||.|....||.|:||||.|...|:|:|::|||...|.|..
Worm   547 RVAWSRVILDEAHAIKNRLSQCSKAVCRLSSFSRWCLSGTPIHNNLWDLYSLVRFLRIPLFGDRK 611

  Fly   659 TWKKWIDNKSAGGQNRLNLLMKSLMLRRTKAQ--LQSDGKLNSLPNKELRLIEISLDKEEMNVYQ 721
            .|.:.|.....|..:|:|||.|:|||||||.|  ..::.|:.:|..|::.:.|:.:..:|.|.|.
Worm   612 FWAESIMPMKTGMADRVNLLTKNLMLRRTKDQQCALTNKKIVNLKEKKIEIHELEMVGDEANGYA 676

  Fly   722 TVMTYSRTLFAQF------------LHQRAERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFA 774
            .:|..::.|..|.            :.:|.:|..|..:.:..|....|
Worm   677 IMMEAAQKLVKQIVTNTDDIQKYGQIRRRRQRGNDDEFANPYNVGPRN----------------- 724

  Fly   775 RMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHSSDSDTPEIDLLAQLNKLA 839
             :||:........||:||:||||.|.|..:..:.:|.:..:..|....|:|..|::.|.:.....
Worm   725 -LAGNSNFQNMSCILLLLMRLRQACVHFHITKSGMDLDAFKINGGDDEDADMKELENLMEKTMAD 788

  Fly   840 ITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRPSSKINMVIQILKTSIL 904
            :|...:|..:...:...:.|...|..                :|.....|.|:...:::::..:.
Worm   789 LTIADSDNDEEGVDTNKEEPKQPPTR----------------IFEPDFISCKMAKTLEVVREILE 837

  Fly   905 KSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLT 969
            |.  :|.::||||||||:::..|:...|....|:.|.:.||:||:.|:.||......:|:|||||
Worm   838 KK--EKVVIVSQWTSVLNLVEKHIQAGGHNYTSITGQVLVKDRQERVDSFNQEKGGAQVMLLSLT 900

  Fly   970 AGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKL 1034
            ||||||||||.|||:::||||||.||.||.|||||:||||.|.|::.:...|:|||:..||:|||
Worm   901 AGGVGLNLIGGNHLIMVDLHWNPALEQQACDRIYRMGQKKEVFIHRLIVKGTIEQRVMDLQEKKL 965

  Fly  1035 DLADGVL--TGAKVSSKLTIDDLKGLFGM 1061
            .||..||  |..:..:|||..|::.|||:
Worm   966 ALAASVLEGTATRKLNKLTTADIRMLFGL 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	SNF2_N	442..805	CDD:278600	138/407 (34%)
		DEXDc	459..634	CDD:238005	75/205 (37%)
		HELICc	885..1014	CDD:238034	62/128 (48%)
T23H2.3	NP_001032980.2	DUF1635	110..>175	CDD:285087	18/116 (16%)
		SNF2_N	375..750	CDD:278600	137/403 (34%)
		DEXDc	392..587	CDD:238005	75/205 (37%)
		HELICc	822..944	CDD:238034	62/123 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	192	1.000	Domainoid score	I1885
eggNOG	1	0.900	-	-		E1_COG0141
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	395	1.000	Inparanoid score	I1119
Isobase	1	0.950	-	0	Normalized mean entropy	S3486
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132523at2759
OrthoFinder	1	1.000	-	-		FOG0000507
OrthoInspector	1	1.000	-	-		mtm4832
orthoMCL	1	0.900	-	-		OOG6_104027
Panther	1	1.100	-	-	LDO	PTHR45626
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2250
SonicParanoid	1	1.000	-	-		X1278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.810