Protein Alignment lds and chd-7

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_491426.2
• Gene: chd-7 / 172079
• WormBaseID: WBGene00007053
• Length: 2967
• Species: Caenorhabditis elegans
• Alignment Length: 1223
• Identity: 264/1223 - (21%)
• Similarity: 433/1223 - (35%)
• Gaps: 417/1223 - (34%)

  Fly    50 VIDETQSEEEESQSSETAESEKSDESDNSQNSQESED--SEDDSVRPSARNTKRKPL----GIPS 108
            :|:|.:.:.|.||.:...| |..||.:..::.|.:.:  .:|..:....:|.:....    |.|.
 Worm   681 IIEEDEPKYEYSQETIPVE-ELKDEVEFKEDQQSTSNLLEDDTGIDNFVKNEEGAEAGYSNGTPL 744

  Fly   109 DSEDEED----ELEQRALSPSTRMSITGVRPQDLSDD------DSEIEYS-------DEVQEGPT 156
            |..::.|    |.|:..:|         |.|:.:..:      |:| ||.       :|..|.|.
 Worm   745 DQVEQNDYENIEKEEPQVS---------VDPEPVEVEAQQEPADTE-EYPIPSVGTIEEPAEEPA 799

  Fly   157 EAPTAE-------AVVPRYTTQFAGNIQN--DLHSTIGAADSEVLDDSSGSDVLILSNKETPIEI 212
            |.|..|       :.|.:.|...|.:|:|  .:..|.| .:.||.|:.........|:|:   :|
 Worm   800 EEPVEEPEPMDDSSPVDQSTPVKADDIENFAGVEETFG-EEEEVQDEDDDEASSAKSSKD---DI 860

  Fly   213 LSSTDDDATTNKENMSGPP------FERPSKSLSPRSSAGASVVKTSKNLSQPTIQAVLKQKTSP 271
            ....|||.:|..::||..|      |..||...:|...|.:|   ..|:..:|.: .|.|.:...
 Worm   861 KEEEDDDTSTITKDMSEAPSETNDGFTEPSTPATPLMGATSS---KKKSYRRPAV-VVAKSRKKK 921

  Fly   272 AA---------PRRSRIKSE-----------DQKVVSQVVYDEEMRKLAEKRVQVSDAEKLFEKV 316
            :.         |:|.|.|.:           |:..|.....|:|            |.|.|. |:
 Worm   922 SVDDSDDDDFYPQRGRGKKKGGGGKKKADPTDEAGVEGAKSDDE------------DDEFLM-KI 973

  Fly   317 AHKLPDKGSQIMKRIDTLRRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPSIDTLDWDEL 381
            ....||..:.::::|..:|            :...:..||...|.:.:..          :.:|.
 Worm   974 DTPAPDPNAMVVEKILNMR------------MGKVEKKVPETEVAEGSEE----------NGEEK 1016

  Fly   382 SEAVNEIKPVYTGAQGMATFNNQ--KALTLESLKDL----------------HVSLEDLPGPEVL 428
            ||...:.:|...|..|.:..|.:  |:.|.....::                :|..|.....|:|
 Worm  1017 SEEKVKKEPKENGENGESVGNGESSKSKTESETNEIEEEEVEQFLIKWKGRSYVHCEWKTAAELL 1081

  Fly   429 AEDP-VGLKVSLMNHQKHA---------------------------------LAWMS-------- 451
            ..|. |..|:.....:|.:                                 :.|.|
 Worm  1082 EIDKRVEAKIKRFKVKKMSSYIEDDEDFNSDFVIVDRVVDLITEDDGQEFVLIKWKSLGYEEVTW 1146

  Fly   452 -------------WRER-------------------------KLPRGG----------------- 461
                         ||||                         |:.:.|
 Worm  1147 EPIEMIPADKVELWRERQVIDPAKIREKQRPEPEEWKKMSTSKVWKNGNSLREYQFEGVDWLLYC 1211

  Fly   462 -------ILADDMGLGKTLTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGR 519
                   ||||:||||||:..|:.         :|...|...
 Worm  1212 YYNAQNCILADEMGLGKTVQTITF---------LSRIYDYGI----------------------- 1244

  Fly   520 KDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGN--NRETKGKYLRDY---------- 572
                .|..|||.|.|.::.|..|.|:...   :...|:||:  .||...:|...|
 Worm  1245 ----HGPFLVVVPLSTIQNWVREFETWTD---MNAIVYHGSAYAREVLQQYEVFYDKRHCGAKNW 1302

  Fly   573 -------DIVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDL---RGKYR 627
                   |.::||::.|..:.:.|..   :.||..::||||.::|...:  |.|..|   |.::|
 Worm  1303 KKNFVKIDALITTFETVVSDVEFLKK---IPWRVCVIDEAHRLKNRNCK--LLVNGLLAFRMEHR 1362

  Fly   628 WALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAGGQ-NRLNLLMKSLMLRRTKAQL 691
            ..|||||:||...::::||.||....||:..|:.:...:.....| .:|..::|.:||||.|..:
 Worm  1363 VLLTGTPLQNNIDELFSLLNFLHPQQFDNSATFLEQFGSCQTDDQVQKLQEILKPMMLRRLKEDV 1427

  Fly   692 QSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTY 756
            :     .||..||..:||:.|                                    ||..|..|
 Worm  1428 E-----KSLGPKEETIIEVQL------------------------------------SDMQKKFY 1451

  Fly   757 NQIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGDHS 821
            ..|.:.|         |:.:.   |...:..::.:::.||:.|.||.||    :|.|...|.|.
 Worm  1452 RAILERN---------FSHLC---KGTSAPSLMNVMMELRKCCNHPFLI----NGAEEAIMNDF- 1499

  Fly   822 SDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLH 886
                           :||..|.                    ||..:|..:            |.
 Worm  1500 ---------------RLAHPDW--------------------DEETLAHKA------------LI 1517

  Fly   887 RPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIV 951
            :.|.|:.::.::|..  |:....|.::.||...|||:|.:.|.........::|.:....||..:
 Worm  1518 QASGKVVLIEKLLPK--LRKDGHKVLIFSQMVKVLDLLEEFLISMSYPFERIDGNVRGDLRQAAI 1580

  Fly   952 NEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKF 1016
            :.|:..|:.:.|.||...|||:|:||..|:.:::.|..||||.:.|||.|.:|:||||.|.:|:.
 Worm  1581 DRFSKENSDRFVFLLCTRAGGLGINLTAADTVIIFDSDWNPQNDLQAQARCHRIGQKKLVKVYRL 1645

  Fly  1017 MCVDTVEQRIKGLQDKKLDLADGVL---TGAKVS----SKLTIDDL--KGLFG 1060
            :..:|.|:.:......||.|...||   |..|..    ||..:::|  ||.:|
 Worm  1646 ITSNTYEREMFDKASLKLGLDKAVLQSTTALKAEGTALSKKDVEELLKKGAYG 1698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	188/898 (21%)
		DEXHc_TTF2	439..686	CDD:350830	74/372 (20%)
chd-7	NP_491426.2	Atrophin-1	<387..>666	CDD:460830
		PRK12323	<582..732	CDD:481241	12/51 (24%)
		CD1_tandem_CHD5-9_like	979..1095	CDD:349315	22/137 (16%)
		CD2_tandem	1112..1162	CDD:349306	3/49 (6%)
		PLN03142	1197..>1803	CDD:215601	159/653 (24%)
		SANT	2073..2133	CDD:197842
		BRK	2672..2716	CDD:197800