Protein Alignment lds and Hells

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_032260.2
• Gene: Hells / 15201
• MGIID: 106209
• Length: 821
• Species: Mus musculus
• Alignment Length: 875
• Identity: 195/875 - (22%)
• Similarity: 341/875 - (38%)
• Gaps: 253/875 - (28%)

  Fly   265 LKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRVQVSDAEKLFEKVAHKLPDKGSQIMK 329
            :.::|.||....:.::.|:|...:.:..:.:|.:.|:|.......|..:.::.|.| :|.:...|
Mouse     1 MAEQTEPAVITPAMLEEEEQLEAAGLEKERKMLEEAQKSWDRESTEIRYRRLQHLL-EKSNIYSK 64

  Fly   330 RIDTLRRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTG 394
            .:.|...:..::||                 .|......:..|:...:...|.:...| |||...
Mouse    65 FLLTKMEQQQLEEQ-----------------KKKEKLEKKKRSLKLTEGKSLVDGNGE-KPVMKK 111

  Fly   395 AQGM--ATFNNQKALTLESL----------------------------KDLHVSLEDLPGPEVLA 429
            .:|.  .::|..:.::.|.:                            ||.:..::|.....|..
Mouse   112 KRGREDESYNISEVMSKEEILSVAKKHKDNEDESSSTTSLCVEDIQKNKDSNSMIKDRLSQTVRQ 176

  Fly   430 E-----DPV----GLKVSLMNHQKH----ALAW-----MSWRERKLPRG--GILADDMGLGKTLT 474
            .     |||    |..|. ....||    .:.|     |.|.......|  |||||:||||||:.
Mouse   177 NSKFFFDPVRKCNGQPVP-FQQPKHFTGGVMRWYQVEGMEWLRMLWENGINGILADEMGLGKTVQ 240

  Fly   475 MISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRG--GTLVVC-PASLL 536
            .|:::...                                       .:||  |..:|| |.|.|
Mouse   241 CIATIALM---------------------------------------IQRGVPGPFLVCGPLSTL 266

  Fly   537 RQWESEVESKVSRQKLTVCVHHGNNRETKGKYLRD----------YDIVVTTYQIVAREHKSLSA 591
            ..|.:|.  |....::...::|| .||.:.|.:::          :.:|||:::|..|:..:|..
Mouse   267 PNWMAEF--KRFTPEIPTLLYHG-TREDRRKLVKNIHKRQGTLQIHPVVVTSFEIAMRDQNALQH 328

  Fly   592 VFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDD 656
            .:   |:.:|:||.|.::|.|.:....:.......:..|||||:||...::::||.||....|||
Mouse   329 CY---WKYLIVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTPLQNNLSELWSLLNFLLPDVFDD 390

  Fly   657 LHTWKKWIDNKSAG-----------GQNRLNLLMKSL---MLRRTKAQLQSDGKLNSLPNKELRL 707
            |.:::.|.|..|..           .||.|::|.:.|   :|||    |:||..|...|.:|:.:
Mouse   391 LKSFESWFDITSLSETAEDIIAKEREQNVLHMLHQILTPFLLRR----LKSDVALEVPPKREVVV 451

  Fly   708 IEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERET---------------DFNYRSDANKPT-- 755
            .....:|:|  ::.|.:. :||:...|  ...|:||               ..||......|:
Mouse   452 YAPLCNKQE--IFYTAIV-NRTIANMF--GSCEKETVELSPTGRPKRRSRKSINYSELDQFPSEL 511

  Fly   756 ---YNQIKDPNGAYYKMHEKFARMAG-----SKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGE 812
               .:||:.      :::.:...:.|     |:..:|..:|::|   ||:.|.||.:|:..:|..
Mouse   512 EKLISQIQP------EVNRERTVVEGNIPIESEVNLKLRNIMML---LRKCCNHPYMIEYPIDPV 567

  Fly   813 ESQTMGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLK 877
            ..:...|.         :|:....|..|.|.                 :||:
Mouse   568 TQEFKIDE---------ELVTNSGKFLILDR-----------------MLPE------------- 593

  Fly   878 RSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTI 942
                                      ||....|.:|.||.||:||||.|:..........|:|::
Mouse   594 --------------------------LKKRGHKVLVFSQMTSMLDILMDYCHLRNFIFSRLDGSM 632

  Fly   943 PVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQ 1007
            ....|:..:..|| .:....:.|:|..|||:|:||..|:.:::.|..||||.:.|||||.:|:||
Mouse   633 SYSEREKNIYSFN-TDPDVFLFLVSTRAGGLGINLTAADTVIIYDSDWNPQSDLQAQDRCHRIGQ 696

  Fly  1008 KKNVIIYKFMCVDTVEQRI--KGLQDKKLD 1035
            .|.|::|:.:..:|::|:|  :....:||:
Mouse   697 TKPVVVYRLVTANTIDQKIVERAAAKRKLE 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	190/853 (22%)
		DEXHc_TTF2	439..686	CDD:350830	71/284 (25%)
Hells	NP_032260.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..120		9/59 (15%)
		DEXHc_HELLS_SMARCA6	203..436	CDD:350767	71/281 (25%)
		PLN03142	204..>781	CDD:215601	158/652 (24%)
		helicase domain I	226..238		9/11 (82%)
		helicase domain Ia	258..266		4/7 (57%)
		helicase domain II	334..341		3/6 (50%)
		helicase domain III	363..370		5/6 (83%)
		helicase domain IV	429..439		5/13 (38%)
		helicase domain IVa	547..559		6/14 (43%)
		'helicase domain IVb	602..609		3/6 (50%)
		helicase domain V	655..668		7/12 (58%)
		helicase domain VI	686..693		5/6 (83%)