Protein Alignment lds and lds

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: XP_061511887.1
• Gene: lds / 1280703
• VectorBaseID: AGAMI1_003319
• Length: 1197
• Species: Anopheles gambiae
• Alignment Length: 1249
• Identity: 528/1249 - (42%)
• Similarity: 704/1249 - (56%)
• Gaps: 240/1249 - (19%)

  Fly     1 MSSENSEYYSDKEEDSVVNNSSLGRSRKSSRL--------SKSSRLSKSSRPSSAGVVIDETQSE 57
            ||::|.......||||..:..|....|::..:        |::...|.:|.|:|:.||    .||
Mosquito     1 MSAQNIFVEDSAEEDSFQDQQSFSTHREAESIVIEETDSDSEAMNSSAASSPNSSSVV----SSE 61

  Fly    58 EEESQSSETAESEKSD-----------ESDNSQNSQESEDSEDDSVRPSARNTKRKPLGIPSDSE 111
            |||.:.|...:.:|..           ||::|...:..|:.:|:|...||...|   |.:.||.|
Mosquito    62 EEEEEESVVRQMKKRQSVRMSLHPIHAESESSDEDETKEEGQDESNDVSAAAGK---LLLTSDDE 123

  Fly   112 DEEDELEQRALSPSTRMSITGVRPQDL---------------SDDDSEI-----------EYSDE 150
            |.|:|:|:||.||:|||||.|:.|.:.               ||||.||           ..||:
Mosquito   124 DGEEEVERRAYSPATRMSIHGIAPAETTEDEDTPTGGGSDGGSDDDEEIIAVPRKQRKNLIISDD 188

  Fly   151 VQE------------------------------GPTEAPTAEAVVPRYTTQFAGNIQND------ 179
            .:|                              .|.|....|:|    .|:.:.::::|
Mosquito   189 EEEEDRKRSRNNMSFNADGTPRPNPKRRNLSTTSPLEQEEQESV----NTKLSSSLKSDEMERSS 249

  Fly   180 -------------------------------LHST-----------------------------I 184
                                           |.||                             .
Mosquito   250 EQVDEREQSRGELSFIGGRHSISMRASIGEKLSSTHIGEMDPLGPMANVETVFASAENAQSPIKE 314

  Fly   185 GAADSEVLDDSS----GSDVLILSNKETPIEILSSTDDD--ATTNKENMSGPPFERPSKSLSPRS 243
            ||..||.:|.:|    .|..:.|..|...|..|||:|||  .|..:|.       |||..:..|.
Mosquito   315 GAHSSEKVDSNSPAKDDSSSVRLIEKSEEILCLSSSDDDGEVTFVEET-------RPSIDVKTRP 372

  Fly   244 SAGASVVKTSKNLSQPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRVQVSD 308
            .|          |.||||.:.:          ||:..::.::.|||..||.::|::||.:.||..
Mosquito   373 QA----------LVQPTITSFV----------RSQDTAQQRQRVSQSEYDAKVRRMAELKSQVVM 417

  Fly   309 AEKLFEKVAHKLPDKGSQIMKRIDTLRR---ELAMDEQWISALRVQQSNVPAVRVVKPTL----- 365
            .:.:....| ||||||:.:::|:..::.   ||:.|        ::.:.....:.:|.|:
Mosquito   418 IDNVMRNSA-KLPDKGAGLVRRLAEVKSQIFELSKD--------IEMTRATPSKGIKKTIQRNFD 473

  Fly   366 -------NPPRAPSIDTLDWDELSEAVNEIKPVYTGAQGMATFNNQKALTLESLKDLHVSLEDLP 423
                   ..|| |: |.:.||.:..|.::|:|.:||.||:|||.|||.||::.|:.||.|:|..|
Mosquito   474 ENISGGDTKPR-PA-DHISWDTIKRATDDIQPRHTGKQGIATFENQKLLTMDRLETLHKSIETCP 536

  Fly   424 GPEVLAEDPVGLKVSLMNHQKHALAWMSWRERKLPRGGILADDMGLGKTLTMISSVLACKNGQEM 488
            ..:.||:.|..||:.||:||:||||||.|||.:.||||||||||||||||:|||.||  |:.:..
Mosquito   537 SEDTLADPPKLLKIELMDHQRHALAWMLWRETQKPRGGILADDMGLGKTLSMISLVL--KSAELD 599

  Fly   489 SEGKDESSDSDSEDDK--NKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLRQWESEVESKVSRQK 551
            .:|:.....|:||||:  .:......|||||||||...||||:||||||:||||.|:.::|.|..
Mosquito   600 PDGEQLERASESEDDEGDEENHNPNGGWKSKGRKDYYAGGTLIVCPASLMRQWEGEITNRVKRNS 664

  Fly   552 LTVCVHHGNNRETKGKYLRDYDIVVTTYQIVAREHKS-----LSAVFGVKWRRIILDEAHVVRNH 611
            |.||||||..||:|.::|..||:|:|||.:|:||.::     .|.|:||.|.|||||||||:|||
Mosquito   665 LAVCVHHGTQRESKPRHLAKYDVVITTYNLVSRESRAGTARGASGVYGVNWERIILDEAHVIRNH 729

  Fly   612 KSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKKWIDNKSAGGQNRLN 676
            ||..|.|.|.|:|:|||.||||||||||:|||||:|||||:||:||..||:|||||:|||..|||
Mosquito   730 KSAMSEACCGLKGRYRWLLTGTPIQNKEMDVYALMKFLRCTPFNDLVHWKRWIDNKTAGGAMRLN 794

  Fly   677 LLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAER 741
            .:|||:||||||.|||..|.|.|||:|.:.:||:.|:|:||||||.|:.||:.|||||||||||:
Mosquito   795 TIMKSIMLRRTKKQLQERGALTSLPSKTIEIIEVQLEKDEMNVYQKVLMYSKHLFAQFLHQRAEK 859

  Fly   742 ETDFNYRSDANKPTYNQIK--DPNGAYYKMHEKFARMAGSK--KEVKSHDILVLLLRLRQICCHP 802
            |...||.....:||::|..  ..|.|:.|:|:|...|..:|  .|||.|.||||||||||:||||
Mosquito   860 EHAINYGFGGARPTFSQRAHGGANQAFDKVHQKLKSMHAAKDGSEVKQHQILVLLLRLRQVCCHP 924

  Fly   803 GLIDAML-DGEES---QTMGDHSSDSDTPEIDLLAQLNKLAITDTSTDGQQSV-ANAGDDGPPL- 861
            |||..|| |.::|   .|.|.....|...|:|||..||||.::|...|.:..| ||.|.||...
Mosquito   925 GLIYEMLSDDDQSNLDMTGGGEEEGSFGAEVDLLGALNKLKLSDVLADHEAKVAANGGADGSKQE 989

  Fly   862 ----LPDE----ARIAKASKNLLKRSNPVFNLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWT 918
                |.|:    ..:|||:..::.:|||:|.:.||||||...:|:|:..|. .:|||||:|||||
Mosquito   990 LSLNLSDQFDRPEAMAKAASKVMLKSNPIFRIERPSSKIEKTMQLLEEKIF-HTDDKAIIVSQWT 1053

  Fly   919 SVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHL 983
            |:||||..|||:..|..:||.|.:.||.|.|||.:||..:.:.:|:|||||||||||||:|||||
Mosquito  1054 SMLDILATHLSERNVPFVSLTGKVQVKFRNDIVLDFNKPSGKSKVMLLSLTAGGVGLNLVGANHL 1118

  Fly   984 LLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLADGVLTG-AKVS 1047
            ||||.|||||||||||||:|||||.|.|.|:||||.:||||:|:.||:.||.:||||||| ....
Mosquito  1119 LLLDPHWNPQLEAQAQDRVYRVGQTKPVYIWKFMCAETVEQKIQALQEHKLGIADGVLTGTVNKG 1183

  Fly  1048 SKLTIDDLKGLFGM 1061
            |||||||||.|||:
Mosquito  1184 SKLTIDDLKSLFGL 1197

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	413/793 (52%)
		DEXHc_TTF2	439..686	CDD:350830	156/253 (62%)
lds	XP_061511887.1	None