Protein Alignment lds and kis

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: XP_061512916.1
• Gene: kis / 1277495
• VectorBaseID: AGAMI1_002666
• Length: 6890
• Species: Anopheles gambiae
• Alignment Length: 1229
• Identity: 264/1229 - (21%)
• Similarity: 458/1229 - (37%)
• Gaps: 409/1229 - (33%)

  Fly     5 NSEYYSDKEEDSVVNNSSLG--RSRKSSRLSKSSRLSKSSRPSSA-GVVIDETQSEEEESQ---- 62
            |..|.:..||||:|....|.  :.|:..:........|...|..| |...:..:||.:|.:
Mosquito  2173 NYVYVNTSEEDSMVVQYVLAVRKGRRELKPDPPPPPPKEKTPEPAEGSAEEAVKSEPKEGEEKAA 2237

  Fly    63 ----SSETAESEKSDESDNSQNSQESEDSEDDSVRPSARNTKRKPLGIPSDSEDEEDELEQRALS 123
                .|||..:|.:.:.:..:..:.|||.||          |:|    .::..|...|:..:..:
Mosquito  2238 AVGDGSETTAAEATVKEEGKELKEVSEDGED----------KKK----EAEDVDASGEVADKEAA 2288

  Fly   124 PSTRMSITGVRPQDLSDDDSEIE-----YSDEVQEG--PTEAPTAEAVVPRYTTQFAGNIQNDLH 181
            |:|  :.|.| |.:.|::....|     .||....|  |.:.|:||.     .::....::.|..
Mosquito  2289 PTT--TATDV-PMETSEETKSTEEKISPESDTANTGAEPEQKPSAED-----ASKAEEKMETDEQ 2345

  Fly   182 STIG-AADSEV-LDDSSGSDVLILSNKETPIEI----LSSTDDDATTNKENMSGPPFERPSKSLS 240
            .::| ||:.:. .::..|.:     .||...::    :.....||.|.||:|. ...|.|.|:.|
Mosquito  2346 ESVGVAAEKDTPAEEKEGEE-----KKEASADVDQQQVKEPVADAATAKESME-TDAEEPPKTES 2404

  Fly   241 PRSSAGASVVKTSKNLSQPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYD--EEMR-----K 298
            ..::|      ..|...||..:..:::|  ||     |:..:.:...::...|  |:|.     :
Mosquito  2405 VNTAA------EDKTAEQPNGEPAVEEK--PA-----RVADKPEAEATEATADGVEKMEVEGESE 2456

  Fly   299 LAEKRVQVSDAEKLFEKVAHKLPDKGSQIMKRIDTLRRELA-----MDEQWISALRVQQSNVPAV 358
            ..||:.:..||                    ..|.:::|.|     .||:...|::.::....:.
Mosquito  2457 GTEKKPEGDDA--------------------AADVVKKESAEGGESTDEKSSEAVKKEEGESAST 2501

  Fly   359 RVVKPTLNPPRAPSIDT--------------LDW---DELSEAVNEIKPVYTGAQGMATFNNQKA 406
            ...:   ..|....||.              .:|   |||.:....:.            |..|.
Mosquito  2502 ETDE---KKPEPVYIDVEEYFVKYRNFSYLHCEWRTEDELLKGDKRVG------------NKIKR 2551

  Fly   407 LTLESLKDLHV--SLEDLP-GPEVLAEDPVGLKVS-LMNHQ----KHALA-WMS----------- 451
            ..::..:.|::  ||::.| .|:.:..|.| |.|| |::.:    ||.|. |.|
Mosquito  2552 FLMKQQQQLNIFESLDEEPFNPDFVEVDRV-LDVSELVDDEGKTVKHYLVKWKSLPYEDSTWELE 2615

  Fly   452 ----------------------WRERKLP--------------RGG------------------- 461
                                  |:.:|.|              :||
Mosquito  2616 DDVDQLKIEQYYKFNKIPPKSEWKTKKRPHPDQWKALPESPTFKGGNKLRPYQLEGLNWLRYSWY 2680

  Fly   462 -----ILADDMGLGKT---LTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKG 518
                 ||||:||||||   ||.::||.
Mosquito  2681 KGNNCILADEMGLGKTIQSLTFVNSVY-------------------------------------- 2707

  Fly   519 RKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHG-------------NNRETKGKYLR 570
             :...||..||:.|.|.:..|:.|.|...   ::.|.|:||             :.|...||.:|
Mosquito  2708 -EYGIRGPFLVIAPLSTIPNWQREFEGWT---EMNVIVYHGSATSRQMIQDYEVHYRTETGKLIR 2768

  Fly   571 D---YDIVVTTYQIVAREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTG 632
            |   :::::||::::..:::.|.   ...||..::||||.::|...:....:..|..::|..|:|
Mosquito  2769 DITKFNVLITTFEMIVTDYQDLK---NFTWRACVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSG 2830

  Fly   633 TPIQNKELDVYALLKFLRCSPFDDLHTW-KKWIDNKSAGGQNRLNLLMKSLMLRRTKAQLQSDGK 696
            ||:||...::::||.||..|.|.....: :::...|:.....:|..|:|.:||||.|..::
Mosquito  2831 TPLQNNVNELFSLLNFLEPSQFACSEEFLREFGSLKTESEVLKLQALLKPMMLRRLKDDVE---- 2891

  Fly   697 LNSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNY----RSDANKPTYN 757
             .||..||..::|:.|...:...|:.::                 |.:|::    .:.||.|
Mosquito  2892 -KSLAPKEETIVEVELTNIQKKYYRGIL-----------------EQNFSFLMKGTTSANIP--- 2935

  Fly   758 QIKDPNGAYYKMHEKFARMAGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGD--- 819
                                         :::..::.||:.|.||.|    |:|.|.|...|
Mosquito  2936 -----------------------------NLMNTMMELRKCCIHPYL----LNGAEDQIQYDYRQ 2967

  Fly   820 -HSSDSDTPEIDLLAQLNKLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVF 883
             |..|:::...:|:....|:.:.|                 .|||.
Mosquito  2968 QHGEDAESYYKNLIVSSGKMVLID-----------------KLLPK------------------- 2996

  Fly   884 NLHRPSSKINMVIQILKTSILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQ 948
                                |:::..:.::.||....||||.|:|.........::|.|....||
Mosquito  2997 --------------------LRANGHRVLIFSQMVRCLDILEDYLMYKKYPFERIDGRIRGNLRQ 3041

  Fly   949 DIVNEFNDRNNQKRVLLLSLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVII 1013
            ..::.::..::.:.|.||...|||:|:||..|:.:::.|..||||.:.|||.|.:|:||:|.|.|
Mosquito  3042 AAIDRYSKPDSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQQKMVKI 3106

  Fly  1014 YKFMCVDTVEQRIKGLQDKKLDLADGVL----TG------AKVSSKLTIDDL--KGLFG 1060
            |:.:|.:|.|:.:......||.|...||    ||      .:..||..|:||  ||.:|
Mosquito  3107 YRLLCRNTYEREMFDKASLKLGLDKAVLQSMNTGQNKDGTQRQLSKKEIEDLLKKGAYG 3165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	184/890 (21%)
		DEXHc_TTF2	439..686	CDD:350830	73/342 (21%)
kis	XP_061512916.1	None