Protein Alignment lds and Chd9

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_001297459.1
• Gene: Chd9 / 109151
• MGIID: 1924001
• Length: 2885
• Species: Mus musculus
• Alignment Length: 1146
• Identity: 241/1146 - (21%)
• Similarity: 425/1146 - (37%)
• Gaps: 364/1146 - (31%)

  Fly    19 NNSSLGRSRKSSRLSKSSRLSKSSRPSSAGVVIDETQSEEEESQSSETAESEKSDESDNSQNSQE 83
            |:..|.|...||:.|..|......:.:...|:.::...:..||:|.:    ||::...:...::.
Mouse   476 NHLCLQRQPPSSKKSDGSGTYTKLQNTQVRVMSEKKPRKRVESESKQ----EKANRIISEAIARA 536

  Fly    84 SEDSEDDSVRPSARNTKR--KPLGIPSDSEDEEDELEQRAL--SPSTRMSITGVRPQDLS--DDD 142
            .|..|        ||..|  .|...||.|.:.::|...|.:  .|..|   ...:|:..|  .:.
Mouse   537 KERGE--------RNIPRVMSPENFPSASVEGKEEKRGRRMKSKPKDR---DNKKPKTYSKLKEK 590

  Fly   143 SEI---------------EYSDEVQEGPTEAPTAEAVVPRYTTQFAGNIQNDLHSTIGAADSEV- 191
            ::|               |.|||:.:       ||        |.:.:...:.||....::.::
Mouse   591 TKIGKLIITLGKKHKRRNESSDELSD-------AE--------QRSQHTFKEQHSQKRRSNRQIK 640

  Fly   192 ----LDDSSGSDVLILSNKETPIEILSSTDDDATTNKENMSGPPFERPSKSLSPRSSAGASVVKT 252
                .:|:.|        |::..|:..|     ...|.|.:.||.|:|
Mouse   641 RKKYAEDAEG--------KQSEEEVKGS-----LRVKRNSAPPPGEQP----------------- 675

  Fly   253 SKNLSQPTIQAVLKQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRVQVSDAEKLFEKVA 317
                    :|..::..:           .||..:|.:::....::|.....|.: |.|:.|.|
Mouse   676 --------LQLFVENPS-----------EEDAAIVDKILACRTVKKEVSPGVML-DIEEFFVK-- 718

  Fly   318 HKLPDKGSQIMKRIDTLRRELAMDEQWISALRVQQ------------SNVPAVRVVKPTLNPPRA 370
                      .|....|..|.|.::|.:...|:||            ::..|....:| .||
Mouse   719 ----------YKNYSYLHCEWATEQQLLKDKRIQQKIKRFKLRQAQRAHFLADMEEEP-FNP--- 769

  Fly   371 PSIDTLDWDELSEAVNEIKPVYTGAQGM-------------ATFNNQKALTLESLKDLHVSLEDL 422
               |.::.|.:.| |:..:...||...:             :|:..::.:.|..:::........
Mouse   770 ---DYVEVDRILE-VSFCEDKDTGESVIYYLVKWCSLPYEDSTWELKEDVDLAKIEEFEQLQASR 830

  Fly   423 PGPEVLAEDPVGL--KV----------SLMNHQKHALAWM--SWRERKLPRGGILADDMGLGKT- 472
            |....|...|..:  |:          .|..:|...|.|:  :|..|   |..||||:||||||
Mouse   831 PDTRHLDRPPSNIWKKIEQSREYKNGNQLREYQLEGLNWLLFNWYNR---RNCILADEMGLGKTI 892

  Fly   473 --LTMISSVLACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASL 535
              :|.:..:|                              :||         .||..|::.|.|.
Mouse   893 QSITFLYEIL------------------------------LTG---------IRGPFLIIAPLST 918

  Fly   536 LRQWESEVESKVSRQKLTVCVHHGN-------------NRETKGKYLRD---YDIVVTTYQIVAR 584
            :..||.|..:...   :.|.|:||:             .|:::|:.:|.   :..::||::::..
Mouse   919 IANWEREFRTWTD---INVVVYHGSLISRQMIQQYEMYFRDSQGRIIRGAYRFQAIITTFEMILG 980

  Fly   585 EHKSLSAVFGVKWRRIILDEAHVVRNH--KSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLK 647
            ....|:|   :.||.:|:||||.::|.  |....|.:.:|  :::..|||||:||...::::||.
Mouse   981 GCGELNA---IDWRCVIIDEAHRLKNKNCKLLEGLKLMNL--EHKVLLTGTPLQNTVEELFSLLH 1040

  Fly   648 FLRCSPFDDLHTW-KKWIDNKSAGGQNRLNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEIS 711
            ||....|....|: :::.|.|:.....:|..::|.:||||.|..::     ..|..||..:||:.
Mouse  1041 FLEPLRFPSESTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVE-----KKLAPKEETIIEVE 1100

  Fly   712 LDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQIKDPNGAYYKMHEKFARM 776
            |...:...|:.::                 |.:|::.|..    ..|...||
Mouse  1101 LTNIQKKYYRAIL-----------------EKNFSFLSKG----AGQTNVPN------------- 1131

  Fly   777 AGSKKEVKSHDILVLLLRLRQICCHPGLIDAMLDGEESQTMGD-----HSSDSDTPEIDLLAQLN 836
                       ::..::.||:.|.||.||    .|.|.:.:|:     :.|.||.....::....
Mouse  1132 -----------LVNTMMELRKCCNHPYLI----KGAEEKILGEFRDTYNPSASDFHLQAMIQSAG 1181

  Fly   837 KLAITDTSTDGQQSVANAGDDGPPLLPDEARIAKASKNLLKRSNPVFNLHRPSSKINMVIQILKT 901
            ||.:.|                 .|||.
Mouse  1182 KLVLID-----------------KLLPK------------------------------------- 1192

  Fly   902 SILKSSDDKAIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRVLLL 966
              :|:...|.::.||....||||.|:|.........::|.:....||..::.|:..::.:.|.||
Mouse  1193 --MKAGGHKVLIFSQMVRCLDILEDYLIHKRYLYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLL 1255

  Fly   967 SLTAGGVGLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQD 1031
            ...|||:|:||..|:..::.|..||||.:.|||.|.:|:||.|.|.:|:.:..::.|:.:.....
Mouse  1256 CTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQNKAVKVYRLVTRNSYEREMFDRAS 1320

  Fly  1032 KKLDLADGVL----------TGAKVSSKLTIDDL--KGLFG 1060
            .||.|...||          :|.:..||..|:||  :|.:|
Mouse  1321 LKLGLDKAVLQSMSGRDSNVSGIQQLSKKEIEDLLRRGAYG 1361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	179/819 (22%)
		DEXHc_TTF2	439..686	CDD:350830	70/270 (26%)
Chd9	NP_001297459.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	173..195
		KLF3_N	219..360	CDD:410554
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..263
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	283..347
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	479..677		48/265 (18%)
		PTZ00121	<510..>765	CDD:173412	60/346 (17%)
		CD1_tandem_CHD5-9_like	685..749	CDD:349315	17/76 (22%)
		CD2_tandem_CHD5-9_like	769..827	CDD:349310	9/64 (14%)
		PLN03142	858..>1479	CDD:215601	158/664 (24%)
		DEXHc_CHD9	859..1080	CDD:350819	70/270 (26%)
		LXXLL motif 1	867..871		2/3 (67%)
		DEAH box	996..999		2/2 (100%)
		LXXLL motif 2	1035..1039		0/3 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1460..1484
		LXXLL motif 3	2030..2034
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2046..2238
		Binds A/T-rich DNA. /evidence=ECO:0000250	2331..2471
		A.T hook-like	2428..2435
		BRK	2472..2512	CDD:462196
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2473..2494
		BRK	2546..2590	CDD:197800
		LXXLL motif 4	2710..2714
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2724..2770
		LXXLL motif 5	2782..2786
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2818..2885