Protein Alignment lds and SRCAP

DIOPT Version :10

• Sequence 1: NP_524850.2
• Gene: lds / 45894
• FlyBaseID: FBgn0002542
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_006653.2
• Gene: SRCAP / 10847
• HGNCID: 16974
• Length: 3230
• Species: Homo sapiens
• Alignment Length: 891
• Identity: 183/891 - (20%)
• Similarity: 314/891 - (35%)
• Gaps: 312/891 - (35%)

  Fly     6 SEYYSDKEEDSVVNNSSLGRSRKSSRLSKSSRLSKSSRPSSAGVVIDE----TQSEEEESQSSET 66
            :|.|||....|:  |..|..|:..|.....|..:.||.|..|..:.||    ...|:||....||
Human   240 TEKYSDLLSQSL--NQPLTSSKAGSSPCLGSSSAASSPPPPASRLDDEDGDFQPQEDEEEDDEET 302

  Fly    67 AESEKSDESDNSQ---------------------------------NSQESEDSEDDSVR----- 93
            .|.|:..|.::::                                 :..::..|.|...|
Human   303 IEVEEQQEGNDAEAQRREIELLRREGELPLEELLRSLPPQLLEGPSSPSQTPSSHDSDTRDGPEE 367

  Fly    94 ---------------PSARNTKRKPLGIPSDSEDE----EDELEQRALSPSTRMSITGVRPQDLS 139
                           |||...:.|....|.:.::|    |:|.|....:.:....:.|
Human   368 GAEEEPPQVLEIKPPPSAVTQRNKQPWHPDEDDEEFTANEEEAEDEEDTIAAEEQLEG------- 425

  Fly   140 DDDSEIEYSDEVQEGPTEAPTAEAVVPRYTTQFAGNIQNDLHSTIGAADSEVLD----DSSGSDV 200
            :.|..:|.|:..:||..   :.|.::.:|...:|.          |:..||..|    |::.||
Human   426 EVDHAMELSELAREGEL---SMEELLQQYAGAYAP----------GSGSSEDEDEDEVDANSSD- 476

  Fly   201 LILSNKETPIEILSSTDDDATTNKENMSGPPFERPSKSLSPRSSAGASVVKTSKNLSQPTIQAVL 265
               ...|.|:|......:|:::..:::.....:...:......::|:|..:.|::
Human   477 ---CEPEGPVEAEEPPQEDSSSQSDSVEDRSEDEEDEHSEEEETSGSSASEESES---------- 528

  Fly   266 KQKTSPAAPRRSRIKSEDQKVVSQVVYDEEMRKLAEKRVQVSDAEKLFEKVAHKLPDKGSQIMKR 330
                         .:|||.:..||...:||           .|             |.|.:.:
Human   529 -------------EESEDAQSQSQADEEEE-----------DD-------------DFGVEYL-- 554

  Fly   331 IDTLRRELAMDEQWISALRVQQSNVPAVRVVKPTLNPPRAPSIDTL----DWDELSEAVNEIKPV 391
                   ||.||        :||...|.       :.|..|...||    :..:::.|...::|
Human   555 -------LARDE--------EQSEADAG-------SGPPTPGPTTLGPKKEITDIAAAAESLQP- 596

  Fly   392 YTGAQGMATFNNQKALTLESLKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAWM-SWRER 455
                         |..||.:             .:|....|:.|:..|..:|...|.|: :..|:
Human   597 -------------KGYTLAT-------------TQVKTPIPLLLRGQLREYQHIGLDWLVTMYEK 635

  Fly   456 KLPRGGILADDMGLGKTLTMISSV--LACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKG 518
            ||  .|||||:||||||:..||.:  |||:.|                           .|
Human   636 KL--NGILADEMGLGKTIQTISLLAHLACEKG---------------------------NW---- 667

  Fly   519 RKDTRRGGTLVVCPASLLRQWESEVESKVSRQKLTVCVHHGNNRETKGKYL-----RDYDIVVTT 578
                  |..|::.|.|::..||.|::......|  :..::|..:|.|.|..     ..:.:.:|:
Human   668 ------GPHLIIVPTSVMLNWEMELKRWCPSFK--ILTYYGAQKERKLKRQGWTKPNAFHVCITS 724

  Fly   579 YQIVAREHKSLSAVFGVKWRRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVY 643
            |::|.::|::...   ..||.:|||||..::|.|||...::.:...:.|..|||||:||..::::
Human   725 YKLVLQDHQAFRR---KNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELW 786

  Fly   644 ALLKFLRCSPFDDLHTWKKWIDNKSAG---GQ--------NRLNLLMKSLMLRRTKAQLQSDGKL 697
            :|:.||....|.....:|:|..|...|   |.        .||:.:::..:|||.|..::
Human   787 SLMHFLMPHVFQSHREFKEWFSNPLTGMIEGSQEYNEGLVKRLHKVLRPFLLRRVKVDVE----- 846

  Fly   698 NSLPNKELRLIEISLDKEEMNVYQTVMTYSRTLFAQFLHQRAERETDFNYRSDANKPTYNQIKDP 762
            ..:|.|...:|...|.|.:           |.|:..|:.|...:||
Human   847 KQMPKKYEHVIRCRLSKRQ-----------RCLYDDFMAQTTTKET------------------- 881

  Fly   763 NGAYYKMHEKFARMAGSKKEVKSH--DILVLLLRLRQICCHPGLID 806
                               ....|  .::.:|::||::|.||.|.|
Human   882 -------------------LATGHFMSVINILMQLRKVCNHPNLFD 908

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lds	NP_524850.2	HepA	287..1041	CDD:440319	121/545 (22%)
		DEXHc_TTF2	439..686	CDD:350830	72/265 (27%)
SRCAP	NP_006653.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71
		HSA	127..193	CDD:462194
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	253..547		60/351 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	559..581		8/36 (22%)
		DEXQc_SRCAP	618..840	CDD:350761	72/265 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1017..1045
		PHA03247	<1031..1592	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1058..1125
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1138..1166
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1320..1366
		PHA03247	<1366..1834	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1406..1425
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1629..1760
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1839..1893
		SF2_C_SNF	2032..2167	CDD:350180
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2214..2233
		COG4372	2241..>2362	CDD:443500
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2271..2298
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2327..2453
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2564..2583
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2598..3081
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3095..3230