Protein Alignment kkv and chs4

DIOPT Version :10

• Sequence 1: NP_524233.1
• Gene: kkv / 45884
• FlyBaseID: FBgn0001311
• Length: 1615
• Species: Drosophila melanogaster
• Sequence 2: XP_017207547.2
• Gene: chs4 / 563138
• ZFINID: ZDB-GENE-060503-308
• Length: 1250
• Species: Danio rerio
• Alignment Length: 1470
• Identity: 479/1470 - (32%)
• Similarity: 714/1470 - (48%)
• Gaps: 325/1470 - (22%)

  Fly    25 VDSDDNNFTDDESSPLTHDIYGGSQRTIQETKGWDVFRDPPIKIETGSTANQ-ECLELTVKILKI 88
            |:.::|...:.|                |:.|.||..|:.||..:.....|: .|       ||.
Zfish    12 VEKEENKQNEKE----------------QQQKFWDTCREVPIIQDDQIPRNRTHC-------LKW 53

  Fly    89 FAYVITFIIVLTGGVIAKGTMLFMTSQVRKDKKMEYCNKDLGRDKSFVVRLPEEERVAWIWALLI 153
            ||..:..:||....:::|.:.|.:.:              .|.:::.::...::...    .|.|
Zfish    54 FACTVVGMIVFILALLSKTSFLLLIT--------------FGNNQTVIIHSDQKPTA----LLAI 100

  Fly   154 AYAL--PEIGALIRSARICFFKTFKVPKTGHFLFVWLMESLSAVGMALLMFVVLPQIDAIQGAML 216
            .:.|  |....|::......||...:|.....|:|..:|.|.|:|.|:|..|.:|..|.:...|:
Zfish   101 GFVLVGPSFLLLLKGTWKFIFKNSTMPSKKTCLWVLCVEILVALGAAVLTIVAMPHFDIVTNVMI 165

  Fly   217 TNCLCVVPGIFGLLSR-TSKEGKRFVKVIIDLAAVAAQVTGLVIWPL--LENRRELWVIPV---- 274
            .|.:.::..||.:::. .:||.|||  :::.|.::...|.|.|::.:  |.....| :||:
Zfish   166 LNSVSILSAIFQVIADCRAKERKRF--ILLPLLSIVFIVLGYVLFVVNYLAFESSL-LIPILLAI 227

  Fly   275 -ACVMISCGWWENYVSPQSPLGLVRALGRIKEEMKYTRYFCHIFLSIWKILLFFTVTLLIYWAQG 338
             ..:.:|..|||||    |.|..:.:|..|.:::..:....:|..|:.:||:...|.
Zfish   228 FGTICVSVNWWENY----SALFTILSLNEIPKDIAKSSNAVNIISSLTRILITSAVI-------- 280

  Fly   339 EEPGNLFAMYGDAFGPHKIIVYELPAGLGGVLPDTLESANIDTVDVDAAYNTVVYVLLLQIFGAY 403
               |...|:.||.:...||:                    .:||        |:.::::|...:.
Zfish   281 ---GVYVALIGDGWKSVKIV--------------------FETV--------VIALVVIQTLSSA 314

  Fly   404 LCYIFGKFACKILIQGFSYAFPV---SLTV------PLSVTFLIA--ACGIRIDDP--------- 448
            ||..|...|||:.....|:..|:   |:.|      ||.:||.::  .....:.:|
Zfish   315 LCRWFVVVACKMHALRRSFVMPMYLASIVVLAVFLSPLVITFPVSNNTISYLVGNPVPLSSTEWV 379

  Fly   449 -CFFHDTIPDYLFFTSPSNFRFNNFVTEQMAWAWILWLLSQTWIALHIWTPKCERLATTEKLFVQ 512
             ....|||...|......|.:....|.  :..:.:.|.|......::||..|..|:..|:.||||
Zfish   380 ELLLIDTIETLLTRDIVVNMKIVGLVC--LGCSALCWWLGLVLSTVYIWFLKIHRIERTKDLFVQ 442

  Fly   513 PMYSSLLIDQSMALNRRRDDQADVKTEDLSEIEKEKGDEYYETISVHTDRSSAPNKPSIKSSDNI 577
            .||....::||:.||.|.:.:..:|     |.:.||     |||
Zfish   443 RMYEGAFLEQSLMLNTRFEIRKKIK-----EKKHEK-----ETI--------------------- 476

  Fly   578 TRIYSCATMWHETKDEMIEFLKSIMRMDEDQCARRVAQKYLRVLDPDYYEFETHIFFDDAFEISD 642
             |::.||||||||.|||::.:.|:.|||:.:  .:..||       ...|||.||:.||||:
Zfish   477 -RVFLCATMWHETYDEMMKIIISMFRMDKYR--PKTEQK-------SDVEFEFHIYVDDAFK--- 528

  Fly   643 HSDDDIQCNRFVKLLIATMDEA---ASEIHQTTIRLRPP----KKYPTPYGGRLVWTLPGKTKFI 700
            ...::...|.:|::|:..:.|.   .||...:..:.:.|    |...||:||||.:|||.....|
Zfish   529 DVKEERHTNEYVEILVDVIKEVYLNFSEEDSSVFKNQQPLPSQKIISTPFGGRLEYTLPKGNVMI 593

  Fly   701 THLKDKDRIRHRKRWSQVMYMYYLLGHRLME--------------LPISVDRKDAI-------AE 744
            .:||||..|||:|||||:||:||:||.||.:              |.::.::.:::       .|
Zfish   594 VNLKDKKLIRHKKRWSQIMYLYYILGWRLHKKYYEKFEAGEDLDCLKVAGEQTESLKEKLKRERE 658

  Fly   745 NTYLLTLDGDIDFKPNAVTLLVDLMKKNKNLGAACGRIHPVGSGPMVWYQLFEYAIGHWLQKATE 809
            |||:|.||||.||:|:||.||:|.:|...::|||||||||.|:|||||||.||||:||||||..|
Zfish   659 NTYILALDGDTDFQPSAVMLLIDRLKLYPDVGAACGRIHPTGTGPMVWYQKFEYAVGHWLQKTAE 723

  Fly   810 HMIGCVLCSPGCFSLFRGKALMDDNVMKKYTTRSDEARHYVQYDQGEDRWLCTLLLQRGYRVEYS 874
            |::|||||||||||||||.|||||||||:||||:.||.|||||||||||||||||||:|:||||:
Zfish   724 HVLGCVLCSPGCFSLFRGAALMDDNVMKRYTTRASEASHYVQYDQGEDRWLCTLLLQQGWRVEYN 788

  Fly   875 AASDAYTHCPEGFNEFYNQRRRWVPSTIANIMDLLADAKRTIKINDNISLLYIFYQMMLMGGTIL 939
            |||||||:.|:.|.|||||||||.|||:||.:|||...:.|.:.|.:||.|||.||::.||.:||
Zfish   789 AASDAYTNAPQDFKEFYNQRRRWGPSTMANTIDLLGSGQLTAERNSSISKLYILYQVLSMGASIL 853

  Fly   940 GPGTIFLMLVGAFVAAFRIDNWTSFHYNIVPILAFMFICFTCKSNIQLFVAQVLSTAYALIM--- 1001
            ||.|:.||:.|.||..|::....:....|||...::.:||..||:.||.:|.::|..||.:|
Zfish   854 GPATVCLMISGGFVFVFKMSENDALILAIVPPAIYLILCFKLKSDTQLTIAAIMSIMYAFLMTGS 918

  Fly  1002 -MAVIVGTALQLGEDGIGSPSAIFLISMVGSFFIAACLHPQEFWCITCGLIYLLSIPSMYLLLIL 1065
             :::|....||   |...:||.:|||.||..:.|.|.|||:||..|..||:|.:.|||.||||.:
Zfish   919 ILSIIGDLVLQ---DTFLTPSGLFLIGMVVLYLITAGLHPKEFSLIIYGLLYFICIPSGYLLLAI 980

  Fly  1066 YSIINLNVVSWGTREVVAKKTKKELEAEKKAAEEAKKRVKQKSMLSFLQSGIGDNGDEEGSVEFS 1130
            |||:|:|.|||||||...       :|:..|....||:        ||.:
Zfish   981 YSIVNMNNVSWGTRESGG-------QAKTSAVNSLKKK--------FLNA--------------- 1015

  Fly  1131 LAGLFRCIFCTHGKTSDE-KQQLTSIAESLDTIKHRMDTIESAVDPHGHHASRHGRRRTTSSGSK 1194
                 .|..|...:..|| ::::|.:.:.                |.|.:.|
Zfish  1016 -----TCCKCPCLEYEDETRREVTQVEDK----------------PEGENIS------------- 1046

  Fly  1195 DHHLLTSVAEKSGDESDESDSDTSAEPKQERDFLTNPYWIE--DP----DVRKGEVDFLSSTEIQ 1253
              .:|:              .:|...|:..:.      ||.  .|    .:|......||..|:.
Zfish  1047 --EILS--------------ENTQIIPQNRKP------WIHSLQPKFGFSLRSESACELSEEELI 1089

  Fly  1254 FWKDLIDQYLYPIDNDPVEQARIAKDLKELRDSSVFAFFMINALFVLIVFLLQLNKDNIHVK--- 1315
            |||::..:||:|::..|.:.|.||.||:|||:...|.:|..|||:::..|.||.....:.:|
Zfish  1090 FWKEMQKKYLHPLEEKPEQLAIIANDLRELRNKVTFVYFFCNALWLVATFFLQAIGGAVTIKIPK 1154

  Fly  1316 -WPFGVRTNITYDESTQEVHISKEYLQLEPIGLVFVFFFALILIIQFTAMLFHRFGTISHIL--A 1377
             :|.|.|:             ..|.|.|:||.|:|:..||.:|||||.|||:||..|..|.:  |
Zfish  1155 IYPNGTRS-------------PTETLSLDPIALMFLLGFAALLIIQFIAMLYHRIYTFIHFVAYA 1206

  Fly  1378 STELNFCKKKSEDLTQDQLIDKHAVEIVKNLQRLQGIDGD 1417
            .||:...:|:|:             ::||.:...:..:||
Zfish  1207 DTEIKAHRKQSQ-------------QVVKFMDHHETFEGD 1233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kkv	NP_524233.1	Chitin_synth_C	583..904	CDD:133033	187/348 (54%)
chs4	XP_017207547.2	RhaT	94..350	CDD:440461	71/305 (23%)
		Chitin_synth_C	481..818	CDD:133033	187/348 (54%)
		Chitin_synth_2	<661..1012	CDD:367353	205/368 (56%)