DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kkv and chs1

DIOPT Version :9

Sequence 1:	NP_524233.1	Gene:	kkv / 45884	FlyBaseID:	FBgn0001311	Length:	1615	Species:	Drosophila melanogaster
Sequence 2:	NP_001303255.1	Gene:	chs1 / 322468	ZFINID:	ZDB-GENE-030131-1188	Length:	1463	Species:	Danio rerio

Alignment Length:	1608	Identity:	477/1608 - (29%)
Similarity:	718/1608 - (44%)	Gaps:	434/1608 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 GSQRTIQETKGWDVFRDPPIKIETGSTANQECLELTVKILKIFAYVITFIIVLTGGVIAKGTMLF 111
            |.:|..:....||.|:..||      .|.:|..::..:||:....|:..:.||..||::||::|.
Zfish     8 GQKREGRHRDTWDPFQLNPI------GAEKEKKQVCFRILQNLVAVLVGLAVLVSGVVSKGSLLV 66

  Fly   112 MTSQVRKDKKMEYCNKDLGRDKSFVVRLPEEERVAWIWALLIAYAL--PEIGALIRSARICFFKT 174
            :|:              |...||.     .:|.....:.||:...|  |.:...:::...|.||:
Zfish    67 LTT--------------LAGPKSL-----RDEVEQQFYGLLLMCVLVTPNLLMFLKALWKCVFKS 112

  Fly   175 FKVPKTGHFLFVWLMESLSAVGMALLMFVVLPQIDAIQGAMLTNCLCVVPGIFGLLSRTSKEGKR 239
            :..|.......|..:|:|.|:|.|:|:.:|:|.:|.:....:...:|:...:..:..|.  :.:|
Zfish   113 YVAPNPRTLGIVCGIEALVALGTAMLVLIVMPNLDILTNLCIPGGICIFSAVLQIAFRL--QTRR 175

  Fly   240 FVKVIIDLAAVAAQVTGLVIWPL----------------LENRRE------LWVIPVACVMISCG 282
            :: ::..:.::...|:|..:..:                |||..:      :.:...|.:::|..
Zfish   176 WM-ILYPICSLILVVSGYFLLGIDYYVREKTYIKHFSDRLENVDDYMTYVYVGIAIFASLLVSLN 239

  Fly   283 WWENYVSPQSPLGLVRALGRIKEEMKYTRYFCHIFLSIWKILLFFTVTLLIYWAQGEEPGNLFAM 347
            ||||      |......:..:..|:...|...::|.|..:|::...|..|.::...   .|.|..
Zfish   240 WWEN------PFQASTNIQEMLSELDTFRDTAYVFTSFIRIVVTLAVYFLYFFVIA---NNQFEW 295

  Fly   348 YGDAFGPHKIIVYELPAGLGGVLPDTLESANIDTVDVDAAYNTVVYVLLLQIFGAYLCYIFGKFA 412
              ||:........|:..||                            ..||.|.:..|:.||..|
Zfish   296 --DAYTKASQATQEIALGL----------------------------FFLQAFCSAACHWFGVVA 330

  Fly   413 CKILIQGFSYAFPVSLTVPLSVTFLIAACGIRIDDPCFF---------------HDTIPDYLFFT 462
            |||....|.:|.||||..|.:   ||....:.:.....|               :|..|......
Zfish   331 CKIHAMKFGFALPVSLIGPAT---LILGMILFVTQSAQFNPSPEIAAIIKGNITNDFWPFCYELK 392

  Fly   463 SPSNFRFNNFVTEQMAWA---------WILWLLSQ-------TWIAL-----HIWTPKCERLATT 506
            |.|:......|..:::::         :.:|..|.       .|:||     :||..|.:|:..|
Zfish   393 SLSDVNTTPVVMLEISYSICKTSLNNPYEMWPFSMLALEGVCMWLALVSCTYYIWKIKVQRIERT 457

  Fly   507 EKLFVQPMYSSLLIDQSMALNRRRDDQADVKTEDLSEIEKEKGDEYYETISVHTDRSSAPNKPSI 571
            ..|||:.:|.|..||.||.||.:.........|..::.|.|.
Zfish   458 SLLFVRRLYESAFIDISMLLNTKMKVIRTANRESNNDAELEN----------------------- 499

  Fly   572 KSSDNITRIYSCATMWHETKDEMIEFLKSIMRMDEDQCARRVAQKYLRVLDPDYYEFETHIFFDD 636
                  ..||.||||||||.|||::.|.|:.|:|..:...:...|       |.::||.||:.||
Zfish   500 ------CVIYLCATMWHETYDEMLKILTSMFRLDRYRGDPKEEHK-------DCFDFECHIYVDD 551

  Fly   637 AFEISDHSDDDIQCNRFVKLLIATMDEAASEIHQTTIRLRPPKK--YPTPYGGRLVWTLPGKTKF 699
            ||.|...|.     .:||...:..:.....|:::......|.:.  ..||||||||:.:|.....
Zfish   552 AFMIEKDSG-----TKFVNTYVEDLIHVVMEVYRVFTNKEPDEVSIIETPYGGRLVFVMPEGNML 611

  Fly   700 ITHLKDKDRIRHRKRWSQVMYMYYLLGHRLMELP----------------ISVD----------- 737
            ..|||||..||::|||||:||:|||||.:...:.                :|:|
Zfish   612 YVHLKDKQLIRNKKRWSQIMYLYYLLGWKGYNVKNPQKITRQNNPCRASLVSLDSETYLLPGLDN 676

  Fly   738 ---RKDAIAENTYLLTLDGDIDFKPNAVTLLVDLMKKNKNLGAACGRIHPVGSGPMVWYQLFEYA 799
               |:....:|||::.||||.||.|.|:.||||.::...|:|||||||||.|.|||||||.||||
Zfish   677 DSKRRHISDDNTYIMALDGDTDFHPKALILLVDRLRMYDNVGAACGRIHPTGMGPMVWYQKFEYA 741

  Fly   800 IGHWLQKATEHMIGCVLCSPGCFSLFRGKALMDDNVMKKYTTRSDEARHYVQYDQGEDRWLCTLL 864
            :||||||..||:.|.|||||||||||||.|||||||:|:|||::..|..||||||||||||||||
Zfish   742 VGHWLQKTAEHVFGSVLCSPGCFSLFRGSALMDDNVLKRYTTKATRASEYVQYDQGEDRWLCTLL 806

  Fly   865 LQRGYRVEYSAASDAYTHCPEGFNEFYNQRRRWVPSTIANIMDLLADAKRTIKINDNISLLYIFY 929
            ||:|:||||:|||||||:.|:.|.|||||||||.|||:||.:|||...|.|:|.|.:||:|||.|
Zfish   807 LQQGWRVEYNAASDAYTNSPQEFKEFYNQRRRWGPSTLANTLDLLHSGKETVKRNTSISMLYILY 871

  Fly   930 QMMLMGGTILGPGTIFLMLVGAFVAAFRIDNWTSFHYNIVPILAFMFICFTCKSNIQLFVAQVLS 994
            |:..:..:||||.::.||:.|||...|.:....|....::|.:.:|.|||..|.|:|:.:|.:||
Zfish   872 QIFTVASSILGPASVTLMIAGAFQFVFGVSGTLSIIIAVIPPVFYMLICFLAKPNLQITIAAILS 936

  Fly   995 TAYALIMMA---------VIVGTALQLGEDGIGSPSAIFLISMVGSFFIAACLHPQEFWCITCGL 1050
            ..||.:|.|         ||.||.:        :|:.:||:|....:.:.|.|||||...|..||
Zfish   937 VIYAFLMTASFFAIIGDMVIQGTFI--------TPTGLFLVSGAILYMVTAVLHPQECTLIIYGL 993

  Fly  1051 IYLLSIPSMYLLLILYSIINLNVVSWGTREVVAKKTKKELEAEKKAAEEAKKRVKQKSMLSFLQS 1115
            :|.:.|||.||||.:||::|:::|||||||    .||         .:|.||:|
Zfish   994 MYFICIPSGYLLLTIYSLVNMHIVSWGTRE----STK---------GKEQKKQV----------- 1034

  Fly  1116 GIGDNGDEEGSVEFSLAGLFRCIFCTHGKTSDEKQQLTSIAESLDTIKHRMDTIESAVDPHGHHA 1180
            |:..|.|              |..|..    |.|.|:|...|:|     .:..::.||:|....|
Zfish  1035 GVVCNRD--------------CRMCCW----DVKIQVTQETENL-----LLQQMQQAVNPTAAAA 1076

  Fly  1181 ----------------------SRHGRRRTTSSG--------SKDHHLLTSVAEKSG-------- 1207
                                  |||.:.:...:.        :||:....|.:|:|.
Zfish  1077 AKAEPEEPATLSAAPEHSSVEISRHVQEKNMENKKDQSKENLNKDNKERDSESERSSSSSSSEKK 1141

  Fly  1208 ----------------DESDESDSD-TSAEPKQ-----------ERDFLTNPYWI---------- 1234
                            |:.|:.|.| .:.|||:           :|:||....:.
Zfish  1142 MDTFNDDTDYEDTDYDDDDDDEDYDYNTVEPKEVVPESAWVEPVKREFLKKLTYANLKRNLQEQI 1206

  Fly  1235 ---------ED----------------------PD------------------------------ 1238
                     ||                      |:
Zfish  1207 RYTLRNKNQEDLCEELVLILTDTLNDELKDKVGPEDVLTETQLEELQYALNEAARRIVKTNRIET 1271

  Fly  1239 --------VRKG--------EVDFLSSTEIQFWKDLIDQYLYPIDNDPVEQARIAKDLKELRDSS 1287
                    |::|        :|:.||..|..||:.|:::||.||.:|......:.::||.||:.:
Zfish  1272 GSQRVERRVKRGIERTLVAPQVEKLSEDEQDFWEKLLERYLKPIQDDKAHLEEVTRELKSLRNKA 1336

  Fly  1288 VFAFFMINALFVLIVFLLQ-LNKDNIHVKWPFGVRTNITYDESTQEVHISKEYLQLEPIGLVFVF 1351
            ||.:|:||.|:|:..|.|| :..|.:.::.|      ..|...|    ::.|.|::||:.|:|:.
Zfish  1337 VFLYFIINVLWVVATFFLQAIGGDVLSIEIP------KYYPNKT----LAPEPLRVEPLSLMFLL 1391

  Fly  1352 FFALILIIQFTAMLFHRFGTISHILA--STELNFCKKKSEDLTQDQLI 1397
            .||::|::||.|||:||..|:.|:::  |:|.|: |:|.|:..:|.||
Zfish  1392 SFAVLLVVQFLAMLYHRVYTLIHVVSYRSSEKNY-KEKDEEDEEDALI 1438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kkv	NP_524233.1	Chitin_synth_C	583..904	CDD:133033	177/352 (50%)
chs1	NP_001303255.1	Glyco_tranf_GTA_type	505..846	CDD:299700	177/352 (50%)
		BcsA	<689..969	CDD:224136	161/287 (56%)
		DUF373	<858..981	CDD:299895	44/130 (34%)
		EcoEI_R_C	1190..>1313	CDD:285638	14/122 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596666
Domainoid	1	1.000	315	1.000	Domainoid score	I1253
eggNOG	1	0.900	-	-		E1_COG1215
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	693	1.000	Inparanoid score	I664
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D124503at2759
OrthoFinder	1	1.000	-	-		FOG0003454
OrthoInspector	1	1.000	-	-		mtm6358
orthoMCL	1	0.900	-	-		OOG6_103357
Panther	1	1.100	-	-	LDO	PTHR22914
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2067
SonicParanoid	1	1.000	-	-		X2824
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790