Protein Alignment kkv and chs1

DIOPT Version :10

• Sequence 1: NP_524233.1
• Gene: kkv / 45884
• FlyBaseID: FBgn0001311
• Length: 1615
• Species: Drosophila melanogaster
• Sequence 2: NP_001303255.1
• Gene: chs1 / 322468
• ZFINID: ZDB-GENE-030131-1188
• Length: 1463
• Species: Danio rerio
• Alignment Length: 1608
• Identity: 477/1608 - (29%)
• Similarity: 718/1608 - (44%)
• Gaps: 434/1608 - (26%)

  Fly    47 GSQRTIQETKGWDVFRDPPIKIETGSTANQECLELTVKILKIFAYVITFIIVLTGGVIAKGTMLF 111
            |.:|..:....||.|:..||      .|.:|..::..:||:....|:..:.||..||::||::|.
Zfish     8 GQKREGRHRDTWDPFQLNPI------GAEKEKKQVCFRILQNLVAVLVGLAVLVSGVVSKGSLLV 66

  Fly   112 MTSQVRKDKKMEYCNKDLGRDKSFVVRLPEEERVAWIWALLIAYAL--PEIGALIRSARICFFKT 174
            :|:              |...||.     .:|.....:.||:...|  |.:...:::...|.||:
Zfish    67 LTT--------------LAGPKSL-----RDEVEQQFYGLLLMCVLVTPNLLMFLKALWKCVFKS 112

  Fly   175 FKVPKTGHFLFVWLMESLSAVGMALLMFVVLPQIDAIQGAMLTNCLCVVPGIFGLLSRTSKEGKR 239
            :..|.......|..:|:|.|:|.|:|:.:|:|.:|.:....:...:|:...:..:..|.  :.:|
Zfish   113 YVAPNPRTLGIVCGIEALVALGTAMLVLIVMPNLDILTNLCIPGGICIFSAVLQIAFRL--QTRR 175

  Fly   240 FVKVIIDLAAVAAQVTGLVIWPL----------------LENRRE------LWVIPVACVMISCG 282
            :: ::..:.::...|:|..:..:                |||..:      :.:...|.:::|..
Zfish   176 WM-ILYPICSLILVVSGYFLLGIDYYVREKTYIKHFSDRLENVDDYMTYVYVGIAIFASLLVSLN 239

  Fly   283 WWENYVSPQSPLGLVRALGRIKEEMKYTRYFCHIFLSIWKILLFFTVTLLIYWAQGEEPGNLFAM 347
            ||||      |......:..:..|:...|...::|.|..:|::...|..|.::...   .|.|..
Zfish   240 WWEN------PFQASTNIQEMLSELDTFRDTAYVFTSFIRIVVTLAVYFLYFFVIA---NNQFEW 295

  Fly   348 YGDAFGPHKIIVYELPAGLGGVLPDTLESANIDTVDVDAAYNTVVYVLLLQIFGAYLCYIFGKFA 412
              ||:........|:..||                            ..||.|.:..|:.||..|
Zfish   296 --DAYTKASQATQEIALGL----------------------------FFLQAFCSAACHWFGVVA 330

  Fly   413 CKILIQGFSYAFPVSLTVPLSVTFLIAACGIRIDDPCFF---------------HDTIPDYLFFT 462
            |||....|.:|.||||..|.:   ||....:.:.....|               :|..|......
Zfish   331 CKIHAMKFGFALPVSLIGPAT---LILGMILFVTQSAQFNPSPEIAAIIKGNITNDFWPFCYELK 392

  Fly   463 SPSNFRFNNFVTEQMAWA---------WILWLLSQ-------TWIAL-----HIWTPKCERLATT 506
            |.|:......|..:::::         :.:|..|.       .|:||     :||..|.:|:..|
Zfish   393 SLSDVNTTPVVMLEISYSICKTSLNNPYEMWPFSMLALEGVCMWLALVSCTYYIWKIKVQRIERT 457

  Fly   507 EKLFVQPMYSSLLIDQSMALNRRRDDQADVKTEDLSEIEKEKGDEYYETISVHTDRSSAPNKPSI 571
            ..|||:.:|.|..||.||.||.:.........|..::.|.|.
Zfish   458 SLLFVRRLYESAFIDISMLLNTKMKVIRTANRESNNDAELEN----------------------- 499

  Fly   572 KSSDNITRIYSCATMWHETKDEMIEFLKSIMRMDEDQCARRVAQKYLRVLDPDYYEFETHIFFDD 636
                  ..||.||||||||.|||::.|.|:.|:|..:...:...|       |.::||.||:.||
Zfish   500 ------CVIYLCATMWHETYDEMLKILTSMFRLDRYRGDPKEEHK-------DCFDFECHIYVDD 551

  Fly   637 AFEISDHSDDDIQCNRFVKLLIATMDEAASEIHQTTIRLRPPKK--YPTPYGGRLVWTLPGKTKF 699
            ||.|...|.     .:||...:..:.....|:::......|.:.  ..||||||||:.:|.....
Zfish   552 AFMIEKDSG-----TKFVNTYVEDLIHVVMEVYRVFTNKEPDEVSIIETPYGGRLVFVMPEGNML 611

  Fly   700 ITHLKDKDRIRHRKRWSQVMYMYYLLGHRLMELP----------------ISVD----------- 737
            ..|||||..||::|||||:||:|||||.:...:.                :|:|
Zfish   612 YVHLKDKQLIRNKKRWSQIMYLYYLLGWKGYNVKNPQKITRQNNPCRASLVSLDSETYLLPGLDN 676

  Fly   738 ---RKDAIAENTYLLTLDGDIDFKPNAVTLLVDLMKKNKNLGAACGRIHPVGSGPMVWYQLFEYA 799
               |:....:|||::.||||.||.|.|:.||||.::...|:|||||||||.|.|||||||.||||
Zfish   677 DSKRRHISDDNTYIMALDGDTDFHPKALILLVDRLRMYDNVGAACGRIHPTGMGPMVWYQKFEYA 741

  Fly   800 IGHWLQKATEHMIGCVLCSPGCFSLFRGKALMDDNVMKKYTTRSDEARHYVQYDQGEDRWLCTLL 864
            :||||||..||:.|.|||||||||||||.|||||||:|:|||::..|..||||||||||||||||
Zfish   742 VGHWLQKTAEHVFGSVLCSPGCFSLFRGSALMDDNVLKRYTTKATRASEYVQYDQGEDRWLCTLL 806

  Fly   865 LQRGYRVEYSAASDAYTHCPEGFNEFYNQRRRWVPSTIANIMDLLADAKRTIKINDNISLLYIFY 929
            ||:|:||||:|||||||:.|:.|.|||||||||.|||:||.:|||...|.|:|.|.:||:|||.|
Zfish   807 LQQGWRVEYNAASDAYTNSPQEFKEFYNQRRRWGPSTLANTLDLLHSGKETVKRNTSISMLYILY 871

  Fly   930 QMMLMGGTILGPGTIFLMLVGAFVAAFRIDNWTSFHYNIVPILAFMFICFTCKSNIQLFVAQVLS 994
            |:..:..:||||.::.||:.|||...|.:....|....::|.:.:|.|||..|.|:|:.:|.:||
Zfish   872 QIFTVASSILGPASVTLMIAGAFQFVFGVSGTLSIIIAVIPPVFYMLICFLAKPNLQITIAAILS 936

  Fly   995 TAYALIMMA---------VIVGTALQLGEDGIGSPSAIFLISMVGSFFIAACLHPQEFWCITCGL 1050
            ..||.:|.|         ||.||.:        :|:.:||:|....:.:.|.|||||...|..||
Zfish   937 VIYAFLMTASFFAIIGDMVIQGTFI--------TPTGLFLVSGAILYMVTAVLHPQECTLIIYGL 993

  Fly  1051 IYLLSIPSMYLLLILYSIINLNVVSWGTREVVAKKTKKELEAEKKAAEEAKKRVKQKSMLSFLQS 1115
            :|.:.|||.||||.:||::|:::|||||||    .||         .:|.||:|
Zfish   994 MYFICIPSGYLLLTIYSLVNMHIVSWGTRE----STK---------GKEQKKQV----------- 1034

  Fly  1116 GIGDNGDEEGSVEFSLAGLFRCIFCTHGKTSDEKQQLTSIAESLDTIKHRMDTIESAVDPHGHHA 1180
            |:..|.|              |..|..    |.|.|:|...|:|     .:..::.||:|....|
Zfish  1035 GVVCNRD--------------CRMCCW----DVKIQVTQETENL-----LLQQMQQAVNPTAAAA 1076

  Fly  1181 ----------------------SRHGRRRTTSSG--------SKDHHLLTSVAEKSG-------- 1207
                                  |||.:.:...:.        :||:....|.:|:|.
Zfish  1077 AKAEPEEPATLSAAPEHSSVEISRHVQEKNMENKKDQSKENLNKDNKERDSESERSSSSSSSEKK 1141

  Fly  1208 ----------------DESDESDSD-TSAEPKQ-----------ERDFLTNPYWI---------- 1234
                            |:.|:.|.| .:.|||:           :|:||....:.
Zfish  1142 MDTFNDDTDYEDTDYDDDDDDEDYDYNTVEPKEVVPESAWVEPVKREFLKKLTYANLKRNLQEQI 1206

  Fly  1235 ---------ED----------------------PD------------------------------ 1238
                     ||                      |:
Zfish  1207 RYTLRNKNQEDLCEELVLILTDTLNDELKDKVGPEDVLTETQLEELQYALNEAARRIVKTNRIET 1271

  Fly  1239 --------VRKG--------EVDFLSSTEIQFWKDLIDQYLYPIDNDPVEQARIAKDLKELRDSS 1287
                    |::|        :|:.||..|..||:.|:::||.||.:|......:.::||.||:.:
Zfish  1272 GSQRVERRVKRGIERTLVAPQVEKLSEDEQDFWEKLLERYLKPIQDDKAHLEEVTRELKSLRNKA 1336

  Fly  1288 VFAFFMINALFVLIVFLLQ-LNKDNIHVKWPFGVRTNITYDESTQEVHISKEYLQLEPIGLVFVF 1351
            ||.:|:||.|:|:..|.|| :..|.:.::.|      ..|...|    ::.|.|::||:.|:|:.
Zfish  1337 VFLYFIINVLWVVATFFLQAIGGDVLSIEIP------KYYPNKT----LAPEPLRVEPLSLMFLL 1391

  Fly  1352 FFALILIIQFTAMLFHRFGTISHILA--STELNFCKKKSEDLTQDQLI 1397
            .||::|::||.|||:||..|:.|:::  |:|.|: |:|.|:..:|.||
Zfish  1392 SFAVLLVVQFLAMLYHRVYTLIHVVSYRSSEKNY-KEKDEEDEEDALI 1438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kkv	NP_524233.1	Chitin_synth_C	583..904	CDD:133033	177/352 (50%)
chs1	NP_001303255.1	Glyco_tranf_GTA_type	505..846	CDD:472172	177/352 (50%)
		Chitin_synth_2	<689..1035	CDD:367353	196/377 (52%)
		SMC_N	1182..>1333	CDD:481474	22/150 (15%)