DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kkv and has3

DIOPT Version :9

Sequence 1:	NP_524233.1	Gene:	kkv / 45884	FlyBaseID:	FBgn0001311	Length:	1615	Species:	Drosophila melanogaster
Sequence 2:	XP_009291796.1	Gene:	has3 / 282555	ZFINID:	ZDB-GENE-021118-1	Length:	558	Species:	Danio rerio

Alignment Length:	610	Identity:	108/610 - (17%)
Similarity:	215/610 - (35%)	Gaps:	220/610 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   566 PNKPSIKSSDNITR-IYSCATMWHETKDEMIEFLKSIMRMDEDQCARRVA---QKYLRVLDPDYY 626
            |::|     .::.| :..|...:.|..|.:.:.|:||         ||::   .|.:.|:|.:..
Zfish    76 PSRP-----QHLRRTVALCIAAYQEDPDYLRKCLRSI---------RRISFPGLKVVLVVDGNRQ 126

  Fly   627 EFETHIFFDDAFEISDHSDDDIQCNRFVKLLIATMDEAASEIHQTTIRLRPPKKYPTPYGGRLVW 691
            |        ||:                  ::....|....:.||               |.:||
Zfish   127 E--------DAY------------------MMDIFQEVMGGVEQT---------------GCVVW 150

  Fly   692 T---------LPGKTKFITHLKDKDRIRH----------RKRWS---QVMY-MYYLLGHRLMELP 733
            .         ..|..|...|.::..|:..          .:.|.   :||| .:..||.
Zfish   151 KGNYHSNGDGGGGGGKGSVHAEEAARVARVVRSCRYSCIMQEWGGKREVMYTAFKALGD------ 209

  Fly   734 ISVDRKDAIAENTYLLTLDGDIDFKPNAVTLLVDLMKKNKNLGAACGRIHPVGSGPMVWYQLFEY 798
             :||         |:...|.|....|.....::.:::::.::|...|.:..:..... |.. |..
Zfish   210 -TVD---------YMQVCDSDTVLDPACTIEMLKILEEDPDVGGVGGDVQILNKYDS-WIS-FLS 262

  Fly   799 AIGHWL----QKATEHMIGCVLCSPGCFSLFRGKALMDDNVMKKYTTRSDEARHYVQ--YDQ--- 854
            ::.:|:    ::|.:...|||.|..|...::|...|                :.:::  |.|
Zfish   263 SVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLL----------------QQFLEPWYHQTFL 311

  Fly   855 ------GEDRWLCTLLLQRGYRVEYSAASDAYTHCPEGFNEFYNQRRRWVPSTIAN-IMDLLADA 912
                  |:||.|...:|..|::.:::|.|...|..|..:..:.||:.||..|.... :.:.|...
Zfish   312 GSKCSFGDDRHLTNRVLSFGFKTKFTARSQCQTETPTQYLRWLNQQTRWSKSYFREWLYNALWFH 376

  Fly   913 KRTIKIN-DNI-----------SLLYIFYQMMLMGGTILGPGTIFLMLVGAFVAAFRIDNWTSFH 965
            |.::.:. :::           :::::||:..|.  .||    :||:.|
Zfish   377 KHSLWMTYESVVTGFFPFFLVATVIHLFYRGRLW--NIL----LFLLTV---------------- 419

  Fly   966 YNIVPILAFMFICFTCKSNIQLFVAQVLSTAYALIMMAVI----VGTALQLGEDGIG-SPSAIFL 1025
             .:|.::...:.||...|.:.:|:     :.|:|:.|:.:    :...|.:.:.|.| |.....:
Zfish   420 -QLVGMVKATYACFLRGSLVMIFM-----SLYSLLYMSSLLPAKIFALLTINKAGWGTSGRKKMV 478

  Fly  1026 ISMVGSFFIAACLHPQEFW--CITCGLIY-----------------LLSIPSMY-----LLLILY 1066
            ::::|:.       |...|  .:..|::|                 |::...:|     :||:||
Zfish   479 VNLIGAV-------PVTVWTAILLGGVVYTIYCEVQEPFTETEKALLIAGTIVYASYWLILLVLY 536

  Fly  1067 SIINLNVVSWGTREVVAKKTKKELE 1091
            ..|            |||:..|..|
Zfish   537 LAI------------VAKRCNKREE 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kkv	NP_524233.1	Chitin_synth_C	583..904	CDD:133033	66/361 (18%)
has3	XP_009291796.1	nodulat_NodC	14..469	CDD:275076	88/509 (17%)
has3	XP_009291796.1	GT2_HAS	85..367	CDD:133056	66/365 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2067
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.800