DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kkv and chs1

DIOPT Version :9

Sequence 1:	NP_524233.1	Gene:	kkv / 45884	FlyBaseID:	FBgn0001311	Length:	1615	Species:	Drosophila melanogaster
Sequence 2:	NP_592838.1	Gene:	chs1 / 2542858	PomBaseID:	SPAC13G6.12c	Length:	859	Species:	Schizosaccharomyces pombe

Alignment Length:	778	Identity:	152/778 - (19%)
Similarity:	277/778 - (35%)	Gaps:	239/778 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   507 EKLFVQPMYSSLLIDQSMALNR----RRDDQADVKTEDLSEIEKEKGD---------EYYETISV 558
            |....||.:|: ...|...:||    :|.::...:.:.:..::...|:         :...|:..
pombe    86 EGFTAQPNFSN-FNKQGNTMNREANFQRTNEKIQRNKSIKRVKLFHGNLILDCPIPKKLLVTLPQ 149

  Fly   559 HTDRSSAPNKPSIKSSD-------------------NITRIYSCATMWHETKDEMIEFLKSIMRM 604
            .|:|..|..:.|..:.|                   ..|.|....||::|.:......:.|:|:.
pombe   150 QTEREFAYMRYSAATCDPQDFSKSLFTLRQPLFFQPRKTEICIAITMYNEDEVLFARTMHSVMKN 214

  Fly   605 DEDQCARRVAQKYLRVLDPDYYEFETHIFFDDAFEISDHSDDDIQCNRFVKLLIATMDEAASEIH 669
            ....|.|:.:|                ::..||::               |:::..:.:..::||
pombe   215 ISHLCTRKNSQ----------------VWGKDAWK---------------KVVVCIISDGRTKIH 248

  Fly   670 QTTIRL------------------RPPKKYPTPYGGRLVWTLPGKTKFITHLKDKDRIRHRKRWS 716
            ..|:..                  :..|.:...|..:|  ::....||    |..||
pombe   249 PRTLAYLAAIGVYQDGIAKNQVNDKEVKAHIYEYTTQL--SIDPNLKF----KGSDR-------- 299

  Fly   717 QVMYMYYLLGHRLMELPISVDRKDAIAENTYLLTLDGDIDFKPNAVTLLVD------------LM 769
                     |...:::...:..|:....|::|.............|.:|:|            |.
pombe   300 ---------GIVPVQMIFCLKEKNQKKLNSHLWFFQAFCPILKPEVCILLDAGTRPGDQSIYHLW 355

  Fly   770 KK---NKNLGAACGRI----HPVGSG---PMVWYQLFEYAIGHWLQKATEHMIGCVLCSPGCFSL 824
            |.   |..:..|||.|    ..:|||   |:|..|.|||.:.:.|.|..|.:.|.:...||.||.
pombe   356 KSFDLNPQVAGACGEIVVMKGKLGSGLINPLVATQNFEYKMSNILDKPVESVFGFISVLPGAFSA 420

  Fly   825 FRGKALMDDN----VMKKY-------TTRSD--EARHYVQYDQGEDRWLCTLLLQR---GYRVEY 873
            :|.:||.:|:    .:..|       |.:|.  ||..|:    .|||.||..|:.:   .:.:.|
pombe   421 YRFEALQNDSQGNGPLASYFKGELQNTGKSGIFEANMYL----AEDRILCFELVSKKNEAWILHY 481

  Fly   874 SAASDAYTHCPEGFNEFYNQRRRWVPSTIANIMDLLADAKRTIKINDNISLLYI-----FYQM-- 931
            ..::.|.|..|:...||..|||||:..:.......:....|..:.:..||..::     .||:
pombe   482 VKSAYADTDVPDRIPEFVLQRRRWLNGSFFAAAYAICHYYRFFRTSHTISRKFMLSIEFIYQLAT 546

  Fly   932 MLMGGTILG---------------------PGTIFL---------MLVGAFVAAF--RIDNWTSF 964
            ::.|...:|                     ||.|..         :||..||.|.  |.....:|
pombe   547 IVFGWFNIGNFFIIFYILTSSLASTSANFLPGEILFRIAIWIYASLLVTCFVLALGNRPHGSPNF 611

  Fly   965 HYNIVPILAFM--FICFTCKSNI-------QLFVAQVLSTAY--ALIMMAVIVGTALQLGEDGIG 1018
            :.::|.:.:.:  ::.| |...|       .:..|...|::|  ||:...|.:...:.|     .
pombe   612 YLSMVIMYSILMGYLLF-CSGWIAYRAISDAIHNASSTSSSYTSALLNSNVFINIVISL-----S 670

  Fly  1019 SPSAIFLISMVGSFFIAACLHPQEFWCITCGLIYLLSIPSMYL-LLILYSIINLNVVSWGTR--- 1079
            |...::|:..:.||         :.|.:....:..:.:..||. :|.:|:..|.:.|||||:
pombe   671 STYGMYLVVSIISF---------DPWHMFTSFVQYIFLSIMYTNVLNVYAFCNTHDVSWGTKGDH 726

  Fly  1080 ------------------EVVAKKTKKELEAEKKAAEEAKKRVKQKSMLSFLQSGIGDNGDEE 1124
                              |:.....:.:::|:   .|:|.|.:...| |.| .|.|.::|::|
pombe   727 FTNNDLGVARLLQKGADVEIAIPTNQSDIDAK---YEDAVKLLASPS-LEF-NSPIINHGEQE 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kkv	NP_524233.1	Chitin_synth_C	583..904	CDD:133033	80/376 (21%)
chs1	NP_592838.1	Chitin_synth_1N	125..195	CDD:285592	9/69 (13%)
		Chitin_synth_1	197..358	CDD:279915	29/214 (14%)
		BcsA	<307..633	CDD:224136	77/330 (23%)
		Glyco_tranf_GTA_type	338..555	CDD:299700	59/220 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47198
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2067
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840