DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kkv and chs-2

DIOPT Version :9

Sequence 1:NP_524233.1 Gene:kkv / 45884 FlyBaseID:FBgn0001311 Length:1615 Species:Drosophila melanogaster
Sequence 2:NP_001300545.1 Gene:chs-2 / 173405 WormBaseID:WBGene00000497 Length:1700 Species:Caenorhabditis elegans


Alignment Length:1697 Identity:663/1697 - (39%)
Similarity:955/1697 - (56%) Gaps:217/1697 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 DSDDNNFTDDESSPLTHDIYGGSQRTIQETKGWDVFRDPPIKIETGSTANQECLELTVKILKIFA 90
            |.|||           |..|..::.|:.|.||||:||..|.|.:  ...:....:.::::||:..
 Worm   103 DRDDN-----------HSNYYIAEGTVTENKGWDIFRLLPPKPD--RLGHGFWHDASLQVLKLAT 154

  Fly    91 YVITFIIVLTGGVIAKGTMLFMTSQVR-KDKKMEYCNKDLGRDKSFVVRLPEEERVAWIWALLIA 154
            :::.|::.|...|:||.|.:.|||.:. ..:.:..||:.:.......|:|.....|.|:||.|:|
 Worm   155 FLVLFLLTLGSAVVAKSTFILMTSAIGWGGQTITICNQVISEATQNTVKLKNAHVVKWVWATLLA 219

  Fly   155 YALPEIGALIRSARICFFKTFKVPKTGHFLFVWLMESLSAVGMALLMFVVLPQIDAIQGAMLTNC 219
            .:.||....:||.....|:..|.|....|:||.::|:..::|:.:|:|.:.|.:||:..|.|||.
 Worm   220 LSAPEALCFVRSMHRTMFRNVKRPTFIQFVFVLIIETFHSIGVGILVFRIFPDLDAVTAAQLTNA 284

  Fly   220 LCVVPGIFGLLSRTSKEGKRFVKVIIDLAAVAAQVTGLVIWPL-LEN-RRELWVIPVACVMISCG 282
            :|.||.|..::||...: ...:.||||.||:|||.:|....|: |.| ::.|..|||:..:||..
 Worm   285 MCFVPAILSVISRKPNK-SALLLVIIDFAAIAAQSSGFWALPMFLPNLQKHLVAIPVSLTLISLA 348

  Fly   283 WWENYVSPQSPLGLVRALGRIKEEMKYTRYFCHIFLSIWKILLFFTVTLLIYWAQ---------- 337
            ||:|:|...|....||.|.:..:.:...|...:.|:|:|||.::.....|...::          
 Worm   349 WWQNFVHRDSVFPPVRTLAKFAQRLSERRSKTYAFVSLWKICIYVVCCFLFISSRMKIEDMLQKD 413

  Fly   338 --GEEPGNLFAMYGDAFGPHKIIVYEL-----------PAGLGGVL----------PDTLESANI 379
              ||:   |.::.|......:|..::|           .||.....          |...|:..:
 Worm   414 PFGEK---LLSVAGHDMNQTQIEKFQLRINQMIEQANREAGFYAAAEKKKQPPKKQPKADEAEQV 475

  Fly   380 DTVDV----------DA--------------AYN-----------TVVY----VLLLQIFGAYLC 405
            |..:.          ||              :||           |:.|    :::.|....::|
 Worm   476 DAGEYMMKRFKRFIGDAGENEEEEPEEEEFSSYNIYSNYVERNQLTMAYDALWLVIFQFGAVFVC 540

  Fly   406 YIFGKFACKILIQGFSYAFPVSLTVPLSVTFLIAACGIRIDDPCFFHDTIPDYLFF-TSPSNFRF 469
            |...|||||:::|...:|.|::|:||::|..|...|.:|..|.|:..:.:...||: .:.::...
 Worm   541 YHSSKFACKVMMQRMGFALPMALSVPVTVLLLSTNCRMRQKDSCYGTNVLTVELFWQCNGASMSL 605

  Fly   470 NNFVTEQMAWAWILWLLSQTWIALHIWTPKCERLATTEKLFVQPMYSSLLIDQSMALNRRRDDQA 534
            .:|:.....|.|:.||.||.||.:|:|.||.||||.:||||:.|.|....:|||:|.||||||:|
 Worm   606 ADFILTPQTWIWLCWLASQFWITIHLWNPKHERLAKSEKLFILPYYIGAFVDQSLAFNRRRDDKA 670

  Fly   535 DVKTEDLSEIEKEKGDEYYETI---------SVHTDRSSAPN----KPSIKSSDNITRIYSCATM 586
            .:|.||| |.:.|.....||||         ||.:..||...    :.|..|:|.||:||:||||
 Worm   671 KIKAEDL-EFDAEDSSLTYETIPGLQNKTPPSVCSASSSKLENGLIRDSASSADAITKIYACATM 734

  Fly   587 WHETKDEMIEFLKSIMRMDEDQCARRVAQKYLRVLDPDYYEFETHIFFDDAFEISDHSDDDIQCN 651
            ||||..||...|||:.||||||||||.|||||:|:||||||||.|||||||::::::.:.:|  |
 Worm   735 WHETGVEMTCMLKSLFRMDEDQCARRNAQKYLKVIDPDYYEFEAHIFFDDAYDVNEYGEPEI--N 797

  Fly   652 RFVKLLIATMDEAASEIHQTTIRLRPPKKYPTPYGGRLVWTLPGKTKFITHLKDKDRIRHRKRWS 716
            :|||.::..:|:|||.:|||.:||:||||..|||||:|.:.:|||.|...||||..:||||||||
 Worm   798 KFVKQIVNVIDQAASAVHQTQMRLKPPKKAKTPYGGKLTYIMPGKNKLFIHLKDNQKIRHRKRWS 862

  Fly   717 QVMYMYYLLGHRLMELPISVDRKDAIAENTYLLTLDGDIDFKPNAVTLLVDLMKKNKNLGAACGR 781
            ||||:|||||:|||.......||:.|:|||::||||||:||.|::|.|||||||||:.|||||||
 Worm   863 QVMYLYYLLGYRLMMKVDDPSRKEIISENTFILTLDGDVDFTPSSVYLLVDLMKKNRRLGAACGR 927

  Fly   782 IHPVGSGPMVWYQLFEYAIGHWLQKATEHMIGCVLCSPGCFSLFRGKALMDDNVMKKYTTRSDEA 846
            |||.|.|.|||||.||||||||||||||||||||:||||||||||..|||||||.::|..:|:|.
 Worm   928 IHPRGDGAMVWYQKFEYAIGHWLQKATEHMIGCVMCSPGCFSLFRAYALMDDNVARRYALKSEEP 992

  Fly   847 RHYVQYDQGEDRWLCTLLLQRGYRVEYSAASDAYTHCPEGFNEFYNQRRRWVPSTIANIMDLLAD 911
            :|::|||||||||||||||||||||||.|||||.|..|||||||:||||||:||||.||||||.|
 Worm   993 KHFIQYDQGEDRWLCTLLLQRGYRVEYCAASDAQTFAPEGFNEFFNQRRRWIPSTIFNIMDLLKD 1057

  Fly   912 AKRTIKINDNISLLYIFYQMMLMGGTILGPGTIFLMLVGAFVAAFRIDNWTSFHYNIVPILAFMF 976
            .:..:::|::||:.||.||::::..:||||||||:|::||...:|.||...|.....:|::.|:.
 Worm  1058 YRNVVRVNESISIWYIIYQLVMLISSILGPGTIFVMIIGAISISFSIDTLISLVIVSIPVVVFIV 1122

  Fly   977 ICFTCKSNIQLFVAQVLSTAYALIMMAVIVGTALQLGEDGIGSPSAIFLISMVGSFFIAACLHPQ 1041
            :|.|.|...||..||.:...:|::|.||:|||:|||.:||:.||.::|.:::..||..||.|||.
 Worm  1123 VCLTAKPEHQLICAQTIGAIFAMLMTAVVVGTSLQLQKDGLLSPHSMFTVAVATSFLTAAILHPL 1187

  Fly  1042 EFWCITCGLIYLLSIPSMYLLLILYSIINLNVVSWGTREVVAKKTKKELEAEKKAAEEAKKRVKQ 1106
            ||.||..|.||.|:||.||:||.:||:.|::.||||||| ..:.|:|...|:|....        
 Worm  1188 EFTCIIPGTIYFLAIPCMYMLLPIYSVCNMHTVSWGTRE-DPRPTEKNTLAKKTPGN-------- 1243

  Fly  1107 KSMLSFLQSGIGDNGDEEGSVEFSLAGLFRCIFCTHGKTSDEKQQLTSIAESLDTIKHRMDTIES 1171
                  |:||.|....|.....|...|.    ...|..|....::|..:.:.:|.:..:      
 Worm  1244 ------LESGDGAGNSENWCTRFLCCGR----GTVHPMTMVINEKLNEVIKKVDRLDRK------ 1292

  Fly  1172 AVDPHGHHASRHGRRRTTSSGSKDHHLLTSVAEKSGDESDE-------SDSDTSAEPKQERDFLT 1229
                  ||.|. .||.:..|.:.....:...:|...||..|       |:...:|:..|:.....
 Worm  1293 ------HHPSL-ARRASILSSTGGTIQIDKCSEADEDEQAEIEDALEMSNQSHAAKKNQKWKQAQ 1350

  Fly  1230 NPYWIEDPDVRKGEVDFLSSTEIQFWKDLIDQYLYPIDNDPVEQARIAKDLKELRDSSVFAFFMI 1294
            :..|:.|..:::.|.::|...|..||.|:|::||.|:..|..:..|:...|..:|:|....|.||
 Worm  1351 SEAWLADKALKRAEREYLEPEEESFWNDVIERYLSPLIMDGKDMDRLRAGLIAIRNSHTVYFLMI 1415

  Fly  1295 NALFVLIVFLLQLNKDNIHVKWPFGVRTNITY--------DESTQEVHISKEYLQLEPIGLVFVF 1351
            |.:|::.|.:||::||.::::||.|.:.|.|.        |...:||.:... ||||||||||:.
 Worm  1416 NIVFIISVLVLQIHKDCLNIEWPLGPKFNHTVRPCYANHDDNQKEEVWVMTR-LQLEPIGLVFLI 1479

  Fly  1352 FFALILIIQFTAMLFHRFGTISHILASTELNFCKKKSED-LTQDQLIDKHAVEIVKNLQRLQGID 1415
            ||..||:|||.|||.|||||::||:||||| ||.:|:.| |::|:|:.::||||.:.||.::|||
 Worm  1480 FFVSILVIQFLAMLCHRFGTLAHIIASTEL-FCFRKTMDRLSEDELVAQNAVEIARELQAIRGID 1543

  Fly  1416 GDYDNDSGSGPDR-IARRKTIQNLEKARQP--RRQIGTLDVAFKKRFLKLTADAENNPA---TPI 1474
            .:..|......|| |:||:.:||||.:|:.  :|:..|||.||||||..|:::...:||   ...
 Worm  1544 ENAHNIDNPTEDRGISRRRVVQNLESSRKSMMKRKTETLDAAFKKRFFALSSEQTPDPAGFSARD 1608

  Fly  1475 LTRRLTMRAETIRALEVRKNSVMAERRKSAMQTLGAKNEYGITTGAPINNNGALPNQRSGRVSNA 1539
            .::|||:|..||||||.|::|:.                            |.|.|::...|   
 Worm  1609 NSKRLTLRKGTIRALEHRRDSLF----------------------------GTLDNRKDDEV--- 1642

  Fly  1540 GISIKDVFNVNGGGAEQIYGSNGGGTINQGYEHVIDEDGDGNSLRLTTRNPHPHPHHQVSWGQNT 1604
                 |..::.|....::             |.:.....|.||   .|.:.:....:...|.|.|
 Worm  1643 -----DATSMRGPAQRRL-------------ERLFTAQQDQNS---PTSDGNRRKSNSRPWDQPT 1686

  Fly  1605 NGGGGNG 1611
            :....:|
 Worm  1687 SSATSSG 1693

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kkvNP_524233.1 Chitin_synth_C 583..904 CDD:133033 225/320 (70%)
chs-2NP_001300545.1 Chitin_synth_C 731..1050 CDD:133033 225/320 (70%)
Chitin_synth_2 <881..1225 CDD:281178 210/343 (61%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160167753
Domainoid 1 1.000 528 1.000 Domainoid score I140
eggNOG 1 0.900 - - E1_COG1215
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H45347
Inparanoid 1 1.050 1175 1.000 Inparanoid score I104
Isobase 1 0.950 - 1.04027 Normalized mean entropy S6948
OMA 1 1.010 - - QHG46358
OrthoDB 1 1.010 - - D124503at2759
OrthoFinder 1 1.000 - - FOG0003454
OrthoInspector 1 1.000 - - oto17989
orthoMCL 1 0.900 - - OOG6_103357
Panther 1 1.100 - - LDO PTHR22914
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2067
SonicParanoid 1 1.000 - - X2824
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1716.790

Return to query results.
Submit another query.