Protein Alignment kar and SLC16A3

DIOPT Version :10

• Sequence 1: NP_001189213.1
• Gene: kar / 45883
• FlyBaseID: FBgn0001296
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_004198.1
• Gene: SLC16A3 / 9123
• HGNCID: 10924
• Length: 465
• Species: Homo sapiens
• Alignment Length: 462
• Identity: 123/462 - (26%)
• Similarity: 210/462 - (45%)
• Gaps: 48/462 - (10%)

  Fly    70 GKEPPDGGARAWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKLGDPEASSKAALIGALAIGT 134
            |.:.|||| ..|.|:...|:..|..:.|.....|....|.... .:|..:.:..::::.|:..||
Human    12 GVKAPDGG-WGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEF-GIGYSDTAWISSILLAMLYGT 74

  Fly   135 TFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMFGLGAALAYTPTL 199
            ..|.|.   |: ::.|.|.....||:.::.|::.:||| .:|..:|.|.|::.|||.||.:.|:|
Human    75 GPLCSV---CV-NRFGCRPVMLVGGLFASLGMVAASFC-RSIIQVYLTTGVITGLGLALNFQPSL 134

  Fly   200 AILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFIILCSFVYKP 264
            .:|..||.:.....:|...|||.||...|.|....|...||..|...|:..:.....:|:.:.:|
Human   135 IMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRP 199

  Fly   265 LHPPPEPPKKKPGRSRINLFLRSIINVEIWKRKRFVIWALCVPLALFGYFVPYVHMMQFVKTTFP 329
            |....:|....|..|      |.::::.:::.:.||::|:...:.:.|.|||.|.::.:.|
Human   200 LVVTAQPGSGPPRPS------RRLLDLSVFRDRGFVLYAVAASVMVLGLFVPPVFVVSYAK---- 254

  Fly   330 GEDVNLP-------VMCIGITSGIGRLIFGVIADMPGVN--RMYLQQLSLVSIGLVTLLLPLTNS 385
              |:.:|       :..:|......|...|.:|.:..|.  .:||...|:...||..|.......
Human   255 --DLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSFSMFFNGLADLAGSTAGD 317

  Fly   386 YVILVSFTLVMGLFDGCFISLLGPIAYE----ICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIF 446
            |..||.|.:..|:..|    ::|.:.:|    |.|....:.|||.:|.:.::.:.||||..|.:.
Human   318 YGGLVVFCIFFGISYG----MVGALQFEVLMAIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLL 378

  Fly   447 DSTNSYTLPLILAGLPPLLGSSLLFLIK---CV----KEEENGVSAPRAVVL----ANGDIEIAG 500
            |:|:.|....|||| ..:|.|||:.|:.   |:    ||.:..|:|.....|    |:..:::..
Human   379 DATHVYMYVFILAG-AEVLTSSLILLLGNFFCIRKKPKEPQPEVAAAEEEKLHKPPADSGVDLRE 442

  Fly   501 NGHYRSA 507
            ..|:..|
Human   443 VEHFLKA 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS_MCT8_10	80..474	CDD:340978	109/406 (27%)
SLC16A3	NP_004198.1	MFS_MCT3_4	21..406	CDD:340988	109/407 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	419..438		4/18 (22%)
		Basolateral sorting signal. /evidence=ECO:0000269|PubMed:21199217	423..441		3/17 (18%)
		Basolateral sorting signal. /evidence=ECO:0000269|PubMed:21199217	441..465		2/9 (22%)