DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kar and SLC16A4

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_004687.1	Gene:	SLC16A4 / 9122	HGNCID:	10925	Length:	487	Species:	Homo sapiens

Alignment Length:	494	Identity:	106/494 - (21%)
Similarity:	201/494 - (40%)	Gaps:	91/494 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 GKEPP-----DGGARAWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKLGDPEASSKAALIGA 129
            ||..|     ||| ..|::::..||.|..:.|...|:.:...:..:..     ...|.:...||:
Human     6 GKVQPYTKTLDGG-WGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEF-----EGTSEQIGWIGS 64

  Fly   130 LAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMFGLGAALA 194
            :.....|....:...:.|.:|.:.|:..|..:..||.|:||:.| :|..|..|.|::.|||:|..
Human    65 IMSSLRFCAGPLVAIICDILGEKTTSILGAFVVTGGYLISSWAT-SIPFLCVTMGLLPGLGSAFL 128

  Fly   195 YTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFIILCS 259
            |.....:...|||:.|...:....:|..: |.:|.|....|:..|...|.|.:...::..::..|
Human   129 YQVAAVVTTKYFKKRLALSTAIARSGMGL-TFLLAPFTKFLIDLYDWTGALILFGAIALNLVPSS 192

  Fly   260 FVYKPLHPPPEP-------------------------------------------PKKK------ 275
            .:.:|:|...|.                                           |.|.
Human   193 MLLRPIHIKSENNSGIKDKGSSLSAHGPEAHATETHCHETEESTIKDSTTQKAGLPSKNLTVSQN 257

  Fly   276 --------PGRSRINLFLRS--------------IINVEIWKRKRFVIWALCVPLALFGYFVPYV 318
                    |.|:|  |.|:|              :.::.:::...|.|:.....|:...||:|..
Human   258 QSEEFYNGPNRNR--LLLKSDEESDKVISWSCKQLFDISLFRNPFFYIFTWSFLLSQLAYFIPTF 320

  Fly   319 HMMQFVKTTFPGEDV---NLPVMCIGITSGIGRLIFGVIADMPGVNRMYLQQLSLVSIGLVTLLL 380
            |::...||.  |.|:   :..|...||...:.::|.|.:||...:.:.:..:..|:..|:..||.
Human   321 HLVARAKTL--GIDIMDASYLVSVAGILETVSQIISGWVADQNWIKKYHYHKSYLILCGITNLLA 383

  Fly   381 PLTNSYVILVSFTLVMGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMI 445
            ||..::.:|:::|:...:|.|.:::|:.|:..::|..|...:.:|.....:.:.:..|||:||.:
Human   384 PLATTFPLLMTYTICFAIFAGGYLALILPVLVDLCRNSTVNRFLGLASFFAGMAVLSGPPIAGWL 448

  Fly   446 FDSTNSYTLPLILAGLPPLLGSSLLFLIKCVKEEENGVS 484
            :|.|.:|......:|:..||.|...|.:...:..:|.::
Human   449 YDYTQTYNGSFYFSGICYLLSSVSFFFVPLAERWKNSLT 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	94/451 (21%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	79/388 (20%)
SLC16A4	NP_004687.1	MFS	24..477	CDD:119392	98/463 (21%)
		MFS_1	27..442	CDD:284993	85/425 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..250		1/43 (2%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820