Protein Alignment kar and SLC16A6

DIOPT Version :10

• Sequence 1: NP_001189213.1
• Gene: kar / 45883
• FlyBaseID: FBgn0001296
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: XP_024306789.2
• Gene: SLC16A6 / 9120
• HGNCID: 10927
• Length: 542
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 119/557 - (21%)
• Similarity: 211/557 - (37%)
• Gaps: 127/557 - (22%)

  Fly    44 PSAPVQNGNGNANGTHIEAPCCRDIH-GKEPPDGGARAWLVMVSAFLCNGIIFGFINTYGVIHSL 107
            |..|.:.|......|..:...|...: ..|.|||| ..|.|.||.|......:|.|.|:||..:.
Human     7 PPRPAETGCSRLRMTQNKLKLCSKANVYTEVPDGG-WGWAVAVSFFFVEVFTYGIIKTFGVFFND 70

  Fly   108 LTDRLTKLGDPEASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFC 172
            |.|...     |::|:.:.|.::.:......:.:|..|:::.|.||....||:|.:.|::.:||
Human    71 LMDSFN-----ESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASF- 129

  Fly   173 TENIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSV---FTVI-LPPCLD 233
            ::.:..:|...||:.|||...::.||:.||..||    ||....|||.:|.   |.|. ..|.:.
Human   130 SQEVSHMYVAIGIISGLGYCFSFLPTVTILSQYF----GKRRSIVTAVASTGECFAVFAFAPAIM 190

  Fly   234 KLLGSYGLEGTLRIMSLVSAFIILCSFVYKP--LHPPPEP------------------------- 271
            .|....|...:|..:.|:...|::...:.:|  :..|..|
Human   191 ALKERIGWRYSLLFVGLLQLNIVIFGALLRPIFIRGPASPKIVIQENRKEAQYMLENEKTRTSID 255

  Fly   272 -----------PKKKPGRSRINLFLRS-------------------IINVEIWKRKRFVIWALCV 306
                       ||..|..:.:.|..::                   :::..|.|.|.|:.:||..
Human   256 SIDSGVELTTSPKNVPTHTNLELEPKADMQQVLVKTSPRPSEKKAPLLDFSILKEKSFICYALFG 320

  Fly   307 PLALFGYFVPYVHMMQFVKTTFPGEDVNLPVMCIGITSGI------------------GRLIFGV 353
            ..|..|:|.|                 :|.::.:||:.||                  ||:..|.
Human   321 LFATLGFFAP-----------------SLYIIPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAGF 368

  Fly   354 IADMPGVNRMYLQQLSLVSIGLVTLLLPLTNSYVILVS----FTLVMGLFDGCFISLLGPIAYEI 414
            :.:...:.::|::.:.::.:.:..........:..|:|    |..::|...|..|.||.  ..::
Human   369 VLNREPIRKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLA--EDDV 431

  Fly   415 CGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILAGLPPLLGSSLLFLIKCVK-- 477
            .|....:.|.|..:.:.||....|||:||::.|.:..|:...........|.:..|.|::..|
Human   432 VGIEKMSSAAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALVRPCKMG 496

  Fly   478 ------EEENGVSAPRAVVLAN-----GDIEIAGNGH 503
                  ..|..|.:.|...|.:     .::::|.|.|
Human   497 LCQHHHSGETKVVSHRGKTLQDIPEDFLEMDLAKNEH 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS_MCT8_10	80..474	CDD:340978	101/476 (21%)
SLC16A6	XP_024306789.2	MFS_MCT7	43..491	CDD:340980	101/476 (21%)