DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kar and MCH4

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_014522.1	Gene:	MCH4 / 854030	SGDID:	S000005479	Length:	501	Species:	Saccharomyces cerevisiae

Alignment Length:	418	Identity:	104/418 - (24%)
Similarity:	182/418 - (43%)	Gaps:	50/418 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 KEPPDGGARAWLVMVSAFLCNGIIFGFINTYGVIHSLLT-DRLTKLGDPEASSKAALIGALAIGT 134
            :|.||||.:||||:..||:....:||.||:.|.|.|.:: .:|..:    :||..:.|.:|.:..
Yeast    87 REFPDGGLKAWLVVFGAFMGLVPVFGLINSLGAIESYISKHQLANI----SSSTISWIFSLYLAI 147

  Fly   135 TFLFSTMAGCLTDK---IGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMFGLGAALAYT 196
            :||...::|...|:   |||..|   |.|:.||||...:.| :::......:.:..|||..:..|
Yeast   148 SFLSCILSGGYFDRNGSIGLMCT---GTVIYAGGLFALANC-KSVWQFILAFSVCSGLGTGILMT 208

  Fly   197 PTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFIILCSFV 261
            |.:..:..:|.:..|..:...|.|.|:..::.|..|.||....|.:..:||:|.:....::|:.|
Yeast   209 PLIGTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQWAIRILSFICLTCLICASV 273

  Fly   262 YKPLHPPPEPPKKKPGRSRINL---FLRSIINVEIWKRKRFVIWALCVPLALFGYFVPYVHMMQF 323
               |......|..:|.:|:..:   ::.|:.|...:...:|:..|:....|.........::..:
Yeast   274 ---LARERTKPVVQPFKSKAEVAKWYISSVFNWRYFLEGKFLFVAIGASFAESSLTSCATYLASY 335

  Fly   324 VKTTFPGEDVNLPVMCIGITSGI-GRLIFGVIAD-MPGVNRMYLQQLSLVSIGLVTLLLPLTNSY 386
            ..|....|:|...::......|| ||.|.|..|| ..|...:.:..:|:.::....:.||...:.
Yeast   336 SMTRGNTENVAYTMITASNAVGILGRYIPGYFADKFIGRFNVEIITISMAALFNFVMWLPFGGNT 400

  Fly   387 VILVSFTLVMGLFDGCFISLLGPIAYEIC-GPSGATQAIG-------FLLGLSSIP-LTVGPPVA 442
            .:|.::..:.|...|..:||.     .:| |....|...|       .|..|.:|| |.:|..:.
Yeast   401 KVLWAYVCLWGFSTGSILSLT-----PVCIGQISKTTDFGKRYATVYLLQALVTIPVLPIGGTLI 460

  Fly   443 G----------MIFDSTNSYTLPLILAG 460
            |          :||:|.      |:.||
Yeast   461 GKGTVANYNHFIIFNSA------LMAAG 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	96/405 (24%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	75/331 (23%)
MCH4	NP_014522.1	MFS_MCT_SLC16	96..490	CDD:340910	99/409 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I2205
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9209
orthoMCL	1	0.900	-	-		OOG6_100246
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.810