DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kar and MCH2

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_012701.2	Gene:	MCH2 / 853659	SGDID:	S000001704	Length:	473	Species:	Saccharomyces cerevisiae

Alignment Length:	507	Identity:	114/507 - (22%)
Similarity:	188/507 - (37%)	Gaps:	129/507 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 HTASATNGLVHANGKDAMKPSAPVQNGNGNANGTHIEAPCCRDIHGKEPPDGGARAWLVMVSAFL 89
            |.....|.| :.||||.:         |||   |.|..         |.|||| ..|.::::..|
Yeast     9 HHRDVENKL-NLNGKDDI---------NGN---TSISI---------EVPDGG-YGWFILLAFIL 50

  Fly    90 CNGIIFGFINTYGVIHSLLTDRLTKLGDPEASSKA--ALIGALAIGTTFLFSTMAGCLTDKIGLR 152
            .|...:|..:.|.:..:...:..|..|    .||.  |.||.||......|:.:...|.....::
Yeast    51 YNFSTWGANSGYAIYLAHYLENNTFAG----GSKLDYASIGGLAFSCGLFFAPVITWLYHIFSIQ 111

  Fly   153 LTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFV 217
            .....|.:.....|||::| :..:..:|.|.|::.|.|.|..:.|::.::..:|:......||..
Yeast   112 FIIGLGILFQGAALLLAAF-SVTLWEIYLTQGVLIGFGLAFIFIPSVTLIPLWFRNKRSLASGIG 175

  Fly   218 TAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFIILCSFVYKPLHPPPEPPKKKPGRSRIN 282
            ||||.:..::....:..:|...|::..|      .|..|:|:.:                 |.|.
Yeast   176 TAGSGLGGIVFNLGMQSILQKRGVKWAL------IAQCIICTSL-----------------STIA 217

  Fly   283 LFLRSIINVEIWKRKR--------------FVIWAL--CVPLALFGYFVPYVHMMQF-VKTTFPG 330
            |.|....:..:.:.||              |.:|.|  .|..|:.||.|....:..| |...:..
Yeast   218 LMLTRTTHQGLRQHKRSYKFELLDYDVLSNFAVWLLFGFVSFAMLGYVVLLYSLSDFTVSLGYTS 282

  Fly   331 EDVNLPVMCIGITSGIGRLIFGVIADMPGVNRMYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLV 395
            :..:.....:.:.|.:||.|.|.|||..|          .:::|::               ..||
Yeast   283 KQGSYVSCMVSVGSLLGRPIVGHIADKYG----------SLTVGMI---------------LHLV 322

  Fly   396 MGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILAG 460
            |.:.  |:...:.      |.......|.|.|:|  ||..|:.|.:|.::       |..:.|..
Yeast   323 MAIL--CWAMWIP------CKNLATAIAFGLLVG--SIMGTIWPTIASIV-------TRIVGLQK 370

  Fly   461 LPPLLGSSLLFLIKCVKEEENGVSAPRAVVLANGDIEIA-----GNGHYRSA 507
            ||...||:.:|:            |..|:|.....:|:.     ||.:||:|
Yeast   371 LPGTFGSTWIFM------------AAFALVAPIIGLELRSTDTNGNDYYRTA 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	82/396 (21%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	70/333 (21%)
MCH2	NP_012701.2	MFS_MCT_SLC16	41..428	CDD:340910	97/452 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100246
Panther	1	1.100	-	-	O	PTHR11360
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.900