DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kar and slc16a13

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	XP_001920250.3	Gene:	slc16a13 / 793210	ZFINID:	ZDB-GENE-120907-2	Length:	502	Species:	Danio rerio

Alignment Length:	495	Identity:	124/495 - (25%)
Similarity:	217/495 - (43%)	Gaps:	56/495 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 EAPCCRDIHGKEPPDGGARAWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKLGDPEASSKAA 125
            :.||.:.    ..|||| ..|:|:.:.|:.:.::||.|.:.||.........     .|::...:
Zfish    11 QRPCPQG----AAPDGG-WGWVVVGALFVISALVFGLIRSLGVFFVEFVQYF-----DESAQAVS 65

  Fly   126 LIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMFGLG 190
            .|.::.:....|.|.:....::..|.|.....||.||..|.:|:|..| ::..||.|.|::.|||
Zfish    66 WITSIGLAMQQLMSPIGAAASNVYGTRPVVMMGGFLSGLGFILASQAT-SLLHLYLTMGLISGLG 129

  Fly   191 AALAYTPTLAILGHYF--KRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSA 253
            .||.:|||:|.:..||  :|.|....||...|.:.|.  ..|....|:.:|...|.|.|:..:|.
Zfish   130 WALVFTPTMASVMQYFTKRRSLAMGLGFTGVGLASFA--FSPLFQYLVEAYAWRGALLILGGLSF 192

  Fly   254 FIILCSFVYKPLHPPPEPPKKKPGRSRIN--LFLRSII----NVEIWKRKRFVIWALCVPLALFG 312
            .::.|..:.:|| ..|:...|....:::|  .||.|.|    .:.:...:.||.:|:.:.....|
Zfish   193 NMVACGALIRPL-GTPKVAVKTENSTKLNKCSFLLSRIYECFELSLLTHRGFVTYAVAITFFNAG 256

  Fly   313 YFVPYVHMMQFVK-TTFPGEDVNLPVMCIGITSGIGRLIFGVIADMPGVNRMYLQQLSLVSIGLV 376
            ||:||||::...: ..|........:...|:...:||:..|..:|:..:..:::..:....:||.
Zfish   257 YFIPYVHLVAHSRHIGFTEYQAAFVISITGVADIVGRVASGWASDLGKIRLLHMLVVWTGLLGLS 321

  Fly   377 TLLLPLTNSYVILVSFTLVMGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPV 441
            .:|:|:...|..|:..::|.|...|....|...:..||.|......|:|.|..:.|....:|.|:
Zfish   322 LMLIPVAVVYAGLLLVSIVYGFCAGAMAPLAFAVVPEIVGIERVLGALGLLQLIESAGGLLGAPL 386

  Fly   442 AGMIFDSTNSYTLPLILAG----LPPLLGSSLLFLIKCVKEEENGVSAPRAVVLANGDIEIAGNG 502
            :|.:.|||.:||:..|.||    :..|:..:|.:...|        :||.|
Zfish   387 SGWLKDSTGTYTVSFIAAGSFLMIGMLIAMTLPYFWSC--------TAPPA-------------- 429

  Fly   503 HYRSAGTKSSAPLMGATNGINGSAPAS----PTIQSNGHV 538
               .:.:|..:....|.:|:.|.:.:|    .|:.|..|:
Zfish   430 ---PSPSKKKSQEGSAEDGLIGESTSSNAINETLCSGDHI 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	102/386 (26%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	84/323 (26%)
slc16a13	XP_001920250.3	2A0111	11..443	CDD:331689	117/470 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100246
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.720