DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kar and Slc16a10

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001107804.1	Gene:	Slc16a10 / 72472	MGIID:	1919722	Length:	512	Species:	Mus musculus

Alignment Length:	530	Identity:	215/530 - (40%)
Similarity:	295/530 - (55%)	Gaps:	58/530 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PAANGHTASATNGLVHANGKDAMKPSAPVQNGNGNANG-----------THIEAPCCRDIHGKE- 72
            |||...|..|             :|..|..:.:....|           ..:|....|.. |.|
Mouse     8 PAAERETNEA-------------QPPGPAPSDDAPLPGPGPSDVSDVAAEKVEVELTRSA-GSEP 58

  Fly    73 --PPDGGARAWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKLGDPEASSKAALIGALAIGTT 135
              ||:|| ..||||::|..|||.:||..|.|||:...:.|......|...:.|.|.:|:|::|..
Mouse    59 PVPPEGG-WGWLVMLAAMWCNGSVFGIQNAYGVLFVSMLDTFKAKDDDNMAFKTAWVGSLSMGMI 122

  Fly   136 FLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMFGLGAALAYTPTLA 200
            |....:....||..|.|.|...|..:...||:.||| ..:|..||.||||:|..|.:.||.|:|.
Mouse   123 FFCCPIVSVFTDMFGCRRTAVVGAAVGFIGLMSSSF-VSSIEPLYLTYGIIFACGCSFAYQPSLV 186

  Fly   201 ILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFIILCSFVYKPL 265
            |||||||:.||.|:|.|||||||||::||..|..|:.|..|..||||:.:....:.|..|.|:||
Mouse   187 ILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLGNLISSVKLFNTLRILCIFMFVLFLAGFTYRPL 251

  Fly   266 HPPPEPPKKKPGRSRINLFLR-------SIINVEIWKRKRFVIWALCVPLALFGYFVPYVHMMQF 323
              .|...:|:.|.||.:.|.|       .:.|..::|...:.:||..:|||||||||||||:|..
Mouse   252 --VPSTKEKESGGSRSSFFSRRKLSPPKKVFNFALFKETTYAVWAAGIPLALFGYFVPYVHLMNH 314

  Fly   324 VKTTFPGEDVN---LPVMCIGITSGIGRLIFGVIAD-MPGVNRMYLQQLSLVSIGLVTLLLPLTN 384
            ||..|  :|||   :..||||||||:|||:||.||| :|||.::|||.||...|||:::::||.:
Mouse   315 VKERF--QDVNNKEVLFMCIGITSGVGRLLFGRIADYLPGVKKVYLQVLSFFFIGLMSMMIPLCS 377

  Fly   385 SYVILVSFTLVMGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDST 449
            ::..|::..|.||||||||||::.|||:|:.||..|:||||||||..|||:|||||:||::.|..
Mouse   378 AFGALIAVCLAMGLFDGCFISIMAPIAFELVGPQDASQAIGFLLGFMSIPMTVGPPIAGLLHDKL 442

  Fly   450 NSYTLPLILAGLPPLLGSSLLFLIKCV------KEEENGVSAPRAVVLANGDIEIAGNGHYRSAG 508
            .:|.:...|||:||.:|..:|.||..:      |..:|........:|.|....::|     |:|
Mouse   443 GTYDVAFYLAGIPPFVGGVVLCLIPWIHSKKQRKISKNAGGEKMEKMLENQSSLLSG-----SSG 502

  Fly   509 --TKSSAPLM 516
              .|.||.::
Mouse   503 IFKKDSASII 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	180/388 (46%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	156/325 (48%)
Slc16a10	NP_001107804.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		8/48 (17%)
		2A0113	53..484	CDD:273325	197/437 (45%)
		MFS	68..467	CDD:119392	188/403 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I3234
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75089
Inparanoid	1	1.050	364	1.000	Inparanoid score	I2156
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50069
OrthoDB	1	1.010	-	-		D335911at33208
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		otm42919
orthoMCL	1	0.900	-	-		OOG6_100246
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5423
SonicParanoid	1	1.000	-	-		X2858
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.870