Protein Alignment kar and SLC16A1

DIOPT Version :10

• Sequence 1: NP_001189213.1
• Gene: kar / 45883
• FlyBaseID: FBgn0001296
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_003042.3
• Gene: SLC16A1 / 6566
• HGNCID: 10922
• Length: 500
• Species: Homo sapiens
• Alignment Length: 489
• Identity: 113/489 - (23%)
• Similarity: 199/489 - (40%)
• Gaps: 84/489 - (17%)

  Fly    70 GKEPPDGGARAWLVMVSAFLCNGIIFGF---INTY-----GVIHSLLTDRLTKLGDPEASSKAAL 126
            |..||||| ..|.|::.||:..|..:.|   |..:     |:.|:             .:|:.:.
Human    10 GYTPPDGG-WGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHA-------------TTSEVSW 60

  Fly   127 IGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMFGLGA 191
            |.::.:...:....::..|.:|.|.|:....||.||..||:.:||| ..:..||...|::.|||.
Human    61 ISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFC-NTVQQLYVCIGVIGGLGL 124

  Fly   192 ALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFII 256
            |....|.|.::|.||.:.....:|...|||.||...|.|......|.:|..|:..|:..:.....
Human   125 AFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLLNCC 189

  Fly   257 LCSFVYKPLHPPPEPPKK--------KPGRSRINLFL----------------RSI-------IN 290
            :...:.:|:.|.|....|        |.|:|.:...|                ||:       ::
Human   190 VAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQEKRSVFQTINQFLD 254

  Fly   291 VEIWKRKRFVIWALCVPLALFGYFVPYVHMMQFVKTT-FPGEDVNLPVMCIGITSGIGRLIFGVI 354
            :.::..:.|:::.....:..||.|.|.|.:..:.|:. :..|.....:..:.....:.|...|::
Human   255 LTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAFLLSILAFVDMVARPSMGLV 319

  Fly   355 ADMPGVNR--MYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVMGLFD---GCFISLLGPIAYEI 414
            |:...:..  .|....|:|:.|:..:|.||:.:|   |.|.:..|.|.   |...|:|.....::
Human   320 ANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTY---VGFCVYAGFFGFAFGWLSSVLFETLMDL 381

  Fly   415 CGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYT-------LPLILAGLPPLLGSSLLFL 472
            .||...:.|:|.:..:...|:.:|||:.|.:.|....|.       :.||::|:...:|..:.:.
Human   382 VGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISGIYLFIGMGINYR 446

  Fly   473 I-----------KCVKEEENGVSA---PRAVVLA 492
            :           |..||||..:..   |..|..|
Human   447 LLAKEQKANEQKKESKEEETSIDVAGKPNEVTKA 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS_MCT8_10	80..474	CDD:340978	99/456 (22%)
SLC16A1	NP_003042.3	2A0113	1..455	CDD:273325	105/462 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	454..500		8/27 (30%)