DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kar and Slc16a8

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_113932.2	Gene:	Slc16a8 / 65200	RGDID:	69282	Length:	490	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	136/525 - (25%)
Similarity:	225/525 - (42%)	Gaps:	66/525 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 GKEPPDGGARAWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKLGDPEASSKAALIGALAIGT 134
            |..||||| ..|:|:.:.|:..|..:||.....|..     |..|.......|..|.:.::.:..
  Rat     9 GAGPPDGG-WGWVVLGACFVITGFAYGFPKAVSVFF-----RELKRDFGAGYSDTAWVSSIMLAM 67

  Fly   135 TFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMFGLGAALAYTPTL 199
            .:....::..|..:.|.|....|||:|::.|::|:||.:..: .||.|.|::.|||.||.:.|:|
  Rat    68 LYGTGPLSSILVTRFGCRPVMLAGGLLASAGMILASFASRLL-ELYLTAGVLTGLGLALNFQPSL 131

  Fly   200 AILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGS-YGLEGTLRIMSLVSAFIILCSFVYK 263
            .:||.||:|.....:|...|||.||...|.| |.:|||. :|..|...:...:......|..|.:
  Rat   132 IMLGLYFERRRPLANGLAAAGSPVFLSTLSP-LGQLLGERFGWRGGFLLFGGLLLHCCACGAVMR 195

  Fly   264 PLHPPPEPPKKKP----GRSRINLFLRSIINVEIWKRKRFVIWALCVPLALFGYFVPYVHMMQFV 324
            |  ||...|:..|    ||:|    .|.::::.:...:.|:::.:...|...|.|||.:.::.:.
  Rat   196 P--PPGPQPRPDPAPPGGRAR----HRQLLDLAVCTDRTFMVYMVTKFLMALGLFVPAILLVNYA 254

  Fly   325 KTT-FPGEDVNLPVMCIGITSGIGRLIFGVIADMPGVNRM-----YLQQLSLVSIGLVTLLLPLT 383
            |.. .|..:....:..:|....:.|...|.:|   |:.|:     ||..|:|::.||..|:....
  Rat   255 KDAGVPDAEAAFLLSIVGFVDIVARPACGALA---GLGRLRPHVPYLFSLALLANGLTDLISARA 316

  Fly   384 NSYVILVSFTLVMGLFDGCFISLLGPIAYEI----CGPSGATQAIGFLLGLSSIPLTVGPPVAGM 444
            .||..||:|.:..||..|    ::|.:.:|:    .|......|:|.:|.:.::.:.:|||.||.
  Rat   317 RSYGTLVAFCIAFGLSYG----MVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGR 377

  Fly   445 IFDSTNSYTLPLILAGLPPLLGSSLLFLI-----KCVKEEENGVSAPRAVVLANGDIEIAGNGHY 504
            :.|:..:|.:...|||...:|....:.:.     :|.|:...|.|| ........|:|
  Rat   378 LVDALKNYEIIFYLAGSEVVLAGVFMAVTTYCCQRCSKDIPPGPSA-EGGTSDTEDVE------- 434

  Fly   505 RSAGTKSSAPLMGATNGINGSAPASPTIQSNGHVDNGTGSYPDSPWPSPTRISDSAACDHSSSSL 569
               ..:.|.|:..:|.. .||..|...:....          .||.|....:.|   ..|.|...
  Rat   435 ---AERDSEPMPASTEE-PGSLEALEVLSPRA----------GSPEPEEEAVPD---LSHESVGG 482

  Fly   570 HTNPG 574
            |...|
  Rat   483 HEAHG 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	105/392 (27%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	88/329 (27%)
Slc16a8	NP_113932.2	2A0113	14..440	CDD:273325	119/457 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820