DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kar and slc16a5a

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	XP_021336012.1	Gene:	slc16a5a / 565514	ZFINID:	ZDB-GENE-121108-4	Length:	506	Species:	Danio rerio

Alignment Length:	525	Identity:	119/525 - (22%)
Similarity:	217/525 - (41%)	Gaps:	79/525 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 DAMKPSAPVQNGNGNANGTHIEAPCCRDIHGKEPPDGGARAWLVMVSAFLCNGIIFGFINTYGVI 104
            :.::...|....|.||..::            :.|||| ..|:|:::..:...:...|.:...:.
Zfish    22 EELEKQGPGPPSNANAPDSY------------DAPDGG-WGWVVLLATIIVLALTLAFPSCIIIF 73

  Fly   105 HSLLTDRLTKLGDPEA-SSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLL 168
            :..|....      || :|:.:.:.::..........:...|.|:.|.|.|...|||||..|:.:
Zfish    74 YLDLQKEF------EATNSQTSWVPSIMTAVLHAGGPLCSVLVDRFGCRATVMFGGVLSGFGMAV 132

  Fly   169 SSFCTENIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLD 233
            ||| :.:|..||.|.|::.|||...::.|.:.||||||.|.....:...:.|:::....||...|
Zfish   133 SSF-SHSIVDLYITAGVITGLGFCFSFQPAVTILGHYFVRRRPFANAMSSTGTALGLSTLPFLCD 196

  Fly   234 KLLGSYGLEGTLRIMSLVSAFIILCSFVYKPLHP-----------PPEPPKKKPGRSRINLFLRS 287
            .|....|..|:..::..|.....:|..|.:|:.|           .|:...||.....|...|.|
Zfish   197 FLKIELGWRGSFLVLGAVLLNCCVCGAVMRPIRPRKPRKTNEINNSPKTSDKKGCMLGICQSLAS 261

  Fly   288 IINVEI-----WKRKRFVIWALCVPLALFGYFVPYVHMMQFVKTTFPGEDVN-----LPVMCIGI 342
            .:..::     ....||.:::|.:...:.|:.||.::::.:..    .:|::     |.:..:|.
Zfish   262 SLRQQMAFDLFCSNTRFRVFSLGITWMMLGFVVPLIYLVPYAS----ADDMDPSRAALLLSILGF 322

  Fly   343 TSGIGRLIFGVIADMPGV--NRMYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVMGLFDGCFIS 405
            .:...|...||:..:|..  ..:|:...:|:..||...:..::.|:.:|:.:.|..||......|
Zfish   323 VNIFVRPPVGVLFSLPWFKGRHIYVFSAALLINGLSNSICCISASFPVLLVYVLTYGLSMSVVGS 387

  Fly   406 LLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILAGLPPLLGSSLL 470
            |:..:..:....|....|:|.|..:.|:.|.:|||:||.:.|.|..||...:...:..:|  |.|
Zfish   388 LMFTVLMDTVEMSRFPSALGLLSIMESVTLLIGPPLAGFLVDRTQLYTYVFMACTIIVVL--SAL 450

  Fly   471 FLI---------KCVKEEENGVSAPRAVVLANGDIEIAGNGHYRSAGTKSSAPLMGATNGINGSA 526
            ||:         ...|::.....|          |.|:.:..|      ||.|:    :|...:.
Zfish   451 FLMFTFYWLDSRDAAKKDSPAKPA----------INISTDCQY------SSVPI----DGDKTNK 495

  Fly   527 PASPT 531
            |:|.|
Zfish   496 PSSET 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	94/401 (23%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	78/337 (23%)
slc16a5a	XP_021336012.1	2A0111	38..457	CDD:331689	103/444 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820