DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kar and slc16a3a

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001119873.1	Gene:	slc16a3a / 561627	ZFINID:	ZDB-GENE-061009-16	Length:	501	Species:	Danio rerio

Alignment Length:	498	Identity:	126/498 - (25%)
Similarity:	209/498 - (41%)	Gaps:	75/498 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 PDGGARAWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKLGDPEASSKAALIGALAIGTTFLF 138
            |||| ..|.|:...|:..|..:.|.....|....|. |...:|..:.:..::::.|:..||
Zfish    16 PDGG-WGWAVLFGCFVITGFSYAFPKAVSVFFKELI-REFGVGYSDTAWISSILLAMLYGT---- 74

  Fly   139 STMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMFGLGAALAYTPTLAILG 203
            ..:...|.::.|.|.....||:.::.|::|:||.| :|..:|...|::.|||.||.:.|:|.:|.
Zfish    75 GPLCSILVNRFGCRPVMLVGGLFASLGMILASFAT-SIIHIYLCTGVITGLGMALNFQPSLIMLN 138

  Fly   204 HYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFIILCSFVYKPLHPP 268
            .||.......:|...|||.|....|.|....|...||..|...|:..:......|..:.:||.||
Zfish   139 RYFSEKRPLANGLAAAGSPVALCCLSPLGQVLQYEYGWRGGFLILGGILLNCCACGALMRPLVPP 203

  Fly   269 --PEPP-------------KKKPGRSRINLFLRSIINVEIWKRKRFVIWALCVPLALFGYFVPYV 318
              .|.|             |.||          .:::..:::.:.|:|:.:...:.:.|.|||.|
Zfish   204 KSSEAPGIENAPDDGDKTVKPKP----------KLLDFSVFRDRGFLIYTIAASIMVLGLFVPPV 258

  Fly   319 HMMQFVKTTFPGEDVN--LPVMCIGITSGIGRLIFGVIADMPGVNR--MYLQQLSLVSIGLVTLL 379
            .::.:.| ....||..  |.:..:|......|...|:||.:..|..  :||...:|:..|:..|:
Zfish   259 FVVSYAK-ELGNEDTKSALLLSILGFIDIFARPTCGIIAGLQWVRPRCVYLFSFALIFNGITDLV 322

  Fly   380 LPLTNSYVILVSFTLVMGLFDGCFISLLGPIAYE----ICGPSGATQAIGFLLGLSSIPLTVGPP 440
            ..|:..|..||.|.:..|:..|    ::|.:.:|    :.|....:.|||.:|.|.:|.:.||||
Zfish   323 GSLSKDYTSLVVFCIFFGISYG----MVGALQFEVLMAVVGTEKFSSAIGLVLMLEAIAVLVGPP 383

  Fly   441 VAGMIFDSTNSYTLPLILAGLPPLLGSSLLFLIK--CVKEEENGVSAPRAVVLANGDIEIAGNGH 503
            .||.:.|.|..|....:|||:..:|.:.:|.:..  |:|::.   .||.|..:.:|: .:....|
Zfish   384 SAGRLLDHTKKYMFVFLLAGIEVVLSALVLAICNFLCIKKKP---EAPDAAAVESGE-PVEEKNH 444

  Fly   504 YRSAGTKSSAPLMGATNGINGSAPASPTIQSNGHVDNGTGSYP 546
                                    :||......|..||....|
Zfish   445 ------------------------SSPPATEEPHTPNGNSEKP 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	104/400 (26%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	87/337 (26%)
slc16a3a	NP_001119873.1	2A0113	16..436	CDD:273325	118/444 (27%)
slc16a3a	NP_001119873.1	MFS	22..416	CDD:119392	109/414 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820