DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kar and slc16a8

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001311456.1	Gene:	slc16a8 / 557884	ZFINID:	ZDB-GENE-121128-1	Length:	453	Species:	Danio rerio

Alignment Length:	469	Identity:	119/469 - (25%)
Similarity:	202/469 - (43%)	Gaps:	77/469 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 PDGGARAWLVMVSAFLCNGIIFGF---INTYGVIHSLLTDRLTKLGDPEASSKAALIGALAIGTT 135
            |||| ..|:|::..|:..|..:.|   |:.|  ...|:.|  ...|..:.:..:::|.|:..|:
Zfish    14 PDGG-WGWVVLLGGFVITGFSYAFPKAISVY--FKELMHD--FGCGYKDTAWISSIILAMLYGS- 72

  Fly   136 FLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMFGLGAALAYTPTLA 200
               ..::..:.:|.|.|.....||:|::.|::.:||.| :|..||.|.|::.|||.||.:.|:|.
Zfish    73 ---GPISSIMVNKFGCRPVMLVGGLLASLGMISASFAT-SIIHLYITAGVITGLGLALNFQPSLI 133

  Fly   201 ILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFIIL----CSFV 261
            :||.||.:.....:|...|||.||...|.|....||..||..|..    |::..::|    |..|
Zfish   134 MLGAYFDKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRGGF----LITGGLLLNCCTCGAV 194

  Fly   262 YKPLH--------------PPPE---------------PPKKKPGRSRINLFLRSIINVEIWKRK 297
            .:||.              .|||               |.|||            :::..:.:.|
Zfish   195 MRPLKLKERKACNQELKEMLPPEAGQENIVCENNNDKQPSKKK------------LLDFSVLRDK 247

  Fly   298 RFVIWALCVPLALFGYFVPYVHMMQFVKTT-FPGEDVNLPVMCIGITSGIGRLIFGVIADMPGV- 360
            ..:|:.:...:.:.|.|||.:.::.:.|.. .|.::....:..||......|...||:|.:..|
Zfish   248 GLIIYIIAKFIVVLGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFARPTCGVVAGLKWVR 312

  Fly   361 -NRMYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVMGLFDGCFISLLGPIAYE----ICGPSGA 420
             ...|...|:|:..||..:....:..|..|:.|.:..||..|    ::|.:.:|    |.|.|..
Zfish   313 PKMSYFFSLALLFNGLTDVCSATSTDYKGLIIFCVFFGLSYG----MVGALQFEVLMGIVGTSKF 373

  Fly   421 TQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILAGLPPLLGSSLLFLIK-CVKEEENGVS 484
            :.|:|.:|...::.:.:|||.||.:.|...:|.|...:||...:.....|.|.. |...::....
Zfish   374 SSALGLVLLFEAVAVLIGPPSAGYLVDKYKNYELIFYMAGGELITAGIFLALASFCCISQKKRKD 438

  Fly   485 APRAVVLANGDIEI 498
            :|:.   ...|:|:
Zfish   439 SPQT---QQTDVEV 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	107/420 (25%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	89/354 (25%)
slc16a8	NP_001311456.1	2A0111	14..441	CDD:331689	116/456 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820