DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kar and slc16a12b

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001139286.1	Gene:	slc16a12b / 449947	ZFINID:	ZDB-GENE-050522-80	Length:	488	Species:	Danio rerio

Alignment Length:	472	Identity:	121/472 - (25%)
Similarity:	206/472 - (43%)	Gaps:	71/472 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 GKEPPDGGARAWLVMVSAFL----------CNGIIF-----GFINTYGVIHSLLTDRLTKLGDPE 119
            |..||||| ..|:::...|:          |..|.|     .|...|
Zfish    20 GVLPPDGG-WGWMIVAGCFVVTVCTRAVTRCISIFFVEFQMHFAKDY------------------ 65

  Fly   120 ASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYG 184
              |..|.|.:|...||.|.:.:...:.:::..|:....||.|::.||:||||.| ::..||.|.|
Zfish    66 --SGTAWIHSLVDCTTMLCAPLGSLIGNQLSCRIAVILGGFLASVGLVLSSFAT-SLEYLYATLG 127

  Fly   185 IMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMS 249
            ::.|||.||.|||.:|::|.||........|...:||.:.|.||.|.:..|:..|...|.|.|:.
Zfish   128 LLTGLGFALCYTPAIAMVGIYFCERKALAYGIAMSGSGIGTFILAPVVQLLIEHYSWRGALLILG 192

  Fly   250 LVSAFIILCSFVYKPL-------HPPP---------EPPKKKPGRSRI------NLFLRSIINVE 292
            .....:.:|..:.:|:       .|.|         :||....|.:|.      ....:|:....
Zfish   193 GFVLNLCVCGALLRPIILKEEEACPLPVDSECGYSVKPPTLNGGPTRSAASDAKQRCFQSMQEYH 257

  Fly   293 IWKRKRFVIWALCVPLALFGYFVPYVHMMQFVKTTFPGEDVNLPVMCI-GITSGIGRLIFGVIAD 356
            ......|::.|....|...|..:|:|:::.:......|......:|.| |:...:|.:.||.:.|
Zfish   258 FLLMPDFLVLAGSFLLLASGCSLPFVYLVPYALDVGVGHQHAAFLMSILGVIDIVGNITFGWLTD 322

  Fly   357 MPGV----NRMYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVMGLFDGCFISLLGPIAYEICGP 417
            ...:    |..|:..:.:.  ||..|.:||..::|.||.|:::.|.|||.:::|:..:..::.|.
Zfish   323 RRCLKKYRNICYMFAVGME--GLCCLFIPLLRTFVWLVPFSVLYGYFDGAYVALIPVVTSDVVGR 385

  Fly   418 SGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILAGLPPLLGSSLLFLIKCVK----- 477
            ...:.|:|.:..|.::|..|.||:.|.:.|:|.:||....|:|...:..|.|||.:..::
Zfish   386 QYLSSALGVVYFLHAVPYLVSPPIGGWLVDTTGTYTATFFLSGFALISSSLLLFSVAIIRYCQRN 450

  Fly   478 EEENGVSAPRAVVLANG 494
            :::|.:|....:|...|
Zfish   451 QKKNSLSKIPKLVSCEG 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	105/419 (25%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	90/341 (26%)
slc16a12b	NP_001139286.1	MFS	33..430	CDD:119392	106/419 (25%)
slc16a12b	NP_001139286.1	MFS_1	37..407	CDD:284993	97/392 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100246
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.720