DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kar and slc16a12

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_989310.1	Gene:	slc16a12 / 394932	XenbaseID:	XB-GENE-1012784	Length:	473	Species:	Xenopus tropicalis

Alignment Length:	497	Identity:	126/497 - (25%)
Similarity:	227/497 - (45%)	Gaps:	72/497 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 RDIHGKEPPDGGARAWLVMVSAFL----------CNGIIFGFINTYGVIHSLLTDRLTKLGDPEA 120
            |::| |.||||| ..|::::..|.          |..|.|....:|..               :.
Frog     6 RNLH-KAPPDGG-WGWMIVIGCFFVTVCTRAVTRCISIFFVEFQSYFA---------------QD 53

  Fly   121 SSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYGI 185
            .::.|.|.::...:|.|.:.:...:::....::....||||::.||:||||.| ::..||.|.|:
Frog    54 YARTAWIHSIVDCSTMLCAPIGSYVSNHFSCQVGIILGGVLASTGLVLSSFAT-SLEYLYLTLGV 117

  Fly   186 MFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSL 250
            :.|||.||.|:|.:|::|.||::......|...:||.:.|.||.|.:..|:..:...|.|.|:..
Frog   118 LTGLGFALCYSPAIAMVGKYFEKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGG 182

  Fly   251 VSAFIILCSFVYKP-------LHPP--PEPPKKKPGRS-RINLFLRSIINVEIWKR--------- 296
            ..:.:.:|..:.:|       ||.|  .|..:.:|.:| |::.....:......||
Frog   183 FVSNLCVCGALMRPITLKEDSLHYPLKQEQMENEPTQSGRLDSSCSPLCQDCSHKRLCYCTKKEY 247

  Fly   297 -----KRFVIWALCVPLALFGYFVPYVHMMQF-VKTTFPGEDVNLPVMCIGITSGIGRLIFGVIA 355
                 .:|::.|:......:|...|:|:::.: :......::....:..:||...:|.:.||.:.
Frog   248 SFLLKPKFMVLAVSFLFLAYGCSPPFVYLVPYALNVGVSNQEAAFLMSILGIIDIVGNITFGWVT 312

  Fly   356 DMPGVNR-MYLQQLSLVSI-GLVTLLLPLTNSYVILVSFTLVMGLFDGCFISLLGPIAYEICGPS 418
            |...:.: .|...|..|.: ||..|.||:...:.:||.|:::.|.|||.:::|:..:..::.|.|
Frog   313 DTRFLKKHRYCCYLIAVGLDGLCCLFLPILTRFQLLVPFSVMFGYFDGAYVALIPVVTGDVVGTS 377

  Fly   419 GATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILAGLPPLLGSSLLFLIKCVKEEENGV 483
            ..:.|:|.:..|.::|..|.||:||.:.|:|..||...:|:|...:..:.||.|.|.:...:
Frog   378 SLSSALGVVFFLHAVPYLVSPPIAGWLVDTTGDYTAAFLLSGFSMIFCAVLLALAKIINRIK--- 439

  Fly   484 SAPRAVVLANGDI--EIAGNGHYRSAGTKSSAPLMGATNGIN 523
            ..|:||.:...||  ||..||.            :...|.||
Frog   440 KRPKAVAVPTSDIKQEIWTNGD------------VSCANAIN 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	100/414 (24%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	86/341 (25%)
slc16a12	NP_989310.1	2A0111	12..444	CDD:331689	112/451 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920